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Index > Protein center > Jph3(Gene name) > Mouse
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  • Jph3 (Gene name),
  • Junctophilin-3 (Protein name ),  JPH3_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    Jph3(Jp3);
    Protein name:
    Junctophilin-3(JP-3);
    Alternative:
    Junctophilin type 3;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH3 is brain-specific and appears to have an active role in certain neurons involved in motor coordination and memory.
    Subcellular Location:
    Cell membrane Peripheral membrane protein Endoplasmic reticulum membrane Single-pass type IV membrane protein Localized predominantly on the plasma membrane. The transmembrane domain is anchored in endoplasmic reticulum membrane, while the N-terminal part associates with the plasma membrane.
    Protein Attributes:
    Sequence length:
    744
    Sequence:
    50:
    MSSGGRFNFD | DGGSYCGGWE | DGKAHGHGVC | TGPKGQGEYT | GSWSHGFEVL | 
    100:
    GVYTWPSGNT | YQGTWAQGKR | HGIGLESKGK | WVYKGEWTHG | FKGRYGVREC | 
    150:
    TGNGAKYEGT | WSNGLQDGYG | TETYSDGGTY | QGQWVGGMRQ | GYGVRQSVPY | 
    200:
    GMAAVIRSPL | RTSINSLRSE | HTNGAALHPD | ASPAVAGSPA | VSRGGFVLVA | 
    250:
    HSDSEILKSK | KKGLFRRSLL | SGLKLRKSES | KSSLASQRSK | QSSFRSEAGM | 
    300:
    STVSSTASDI | HSTISLGEAE | AELAVIEDDI | DATTTETYVG | EWKNDKRSGF | 
    350:
    GVSQRSDGLK | YEGEWVSNRR | HGYGCMTFPD | GTKEEGKYKQ | NVLVSGKRKN | 
    400:
    LIPLRASKIR | EKVDRAVEAA | ERAATIAKQK | AEIAASRTSH | SRAKAEAALT | 
    450:
    AAQKAQEEAR | IARITAKEFS | PSFQHRENGL | EYQRPKHQMS | CDDIEVLSTG | 
    500:
    TPLQQESPEL | YRKGTTPSDL | TPDDSPLQSF | PASPTSTPPP | APASRTKMAH | 
    550:
    FSRQVSVDEE | RSGDIQMLLE | GRGGDYARNS | WGEEKAGASR | GIRSGALRSG | 
    600:
    QPTEDFRTRG | SGHKQPGNPK | PRERRTESPT | TFSWTSHHRA | GNPCSGGPKL | 
    650:
    LEPDEEQLSN | YKLEMKPLLR | MDACPQDTHP | QRRRHSRGAG | GDRGFGLQRL | 
    700:
    RSKSQNKENL | RPASSAEPTV | QKLESLRLGD | RPEPRLLRWD | LTFSPPQKSL | 
    744:
    PVALESDEET | GDELKSSTGS | APILVVMVIL | LNIGVAILFI | NFFI
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    KEGG:
    UniGene:
    String:
    Pfam:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse JP-3
    ELISA Kit for Mouse JP-3
    CLIA Kit for Mouse JP-3
    CLIA Kit for Mouse JP-3
    Polyclonal Antibody for Mouse JP-3
    Polyclonal Antibody for Mouse JP-3
    Monoclonal Antibody for Mouse JP-3
    Monoclonal Antibody for Mouse JP-3
    Protein for Mouse JP-3
    Protein for Mouse JP-3

    R&D Technical Data
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    Precision
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Recovery
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    References
    1. 1.
      "Junctophilins: a novel family of junctional membrane complex proteins."
      Takeshima H. , Komazaki S. , Nishi M. , Iino M. , Kangawa K.
      Mol. Cell6:11-22(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA];SUBCELLULAR LOCATION
      strain: 129.
      strain: C57BL/6J.
      tissue: Brain.
    2. 2.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: C57BL/6J.
    3. 3.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    4. 4.
      "Motor discoordination in mutant mice lacking junctophilin type 3."
      Nishi M. , Hashimoto K. , Kuriyama K. , Komazaki S. , Kano M. , Shibata S. , Takeshima H.
      Biochem. Biophys. Res. Commun.292:318-324(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY;DISRUPTION PHENOTYPE
    5. 5.
      "Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
      Trinidad J.C. , Specht C.G. , Thalhammer A. , Schoepfer R. , Burlingame A.L.
      Mol. Cell. Proteomics5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-506;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Brain.
    6. 6.
      "Functional uncoupling between Ca2+ release and afterhyperpolarization in mutant hippocampal neurons lacking junctophilins."
      Moriguchi S. , Nishi M. , Komazaki S. , Sakagami H. , Miyazaki T. , Masumiya H. , Saito S.Y. , Watanabe M. , Kondo H. , Yawo H. , Fukunaga K. , Takeshima H.
      Proc. Natl. Acad. Sci. U.S.A.103:10811-10816(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE;FUNCTION;TISSUE SPECIFICITY;SUBCELLULAR LOCATION
    7. 7.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE
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