Junctophilin-4 (Protein name
), JPH4_RAT from NCBI database.
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General Annotation
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Antigen Annotation
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Gene name:
Jph4(Jphl1);
Protein name:
Junctophilin-4(JP-4);
Alternative:
Junctophilin-like 1 protein;
Organism:
Rat (Rattus norvegicus).
General Annotation
Sub Unit:
N/A
Function:
Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH4 is brain-specific and appears to have an active role in certain neurons involved in motor coordination and memory.
Subcellular Location:
Cell membrane
Peripheral membrane protein
Endoplasmic reticulum membrane
Single-pass type IV membrane protein
Localized predominantly on the plasma membrane. The transmembrane domain is anchored in endoplasmic reticulum membrane, while the N-terminal part associates with the plasma membrane.
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Precision
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Recovery
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Linearity
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References
1.
"Molecular cloning and functional characterization of a novel subclass of junctophilins in the brain." Savaskan N.E.
,
Brauer A.U.
Submitted (2003-07) to the EMBL/GenBank/DDBJ databases
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Cited for: NUCLEOTIDE SEQUENCE [MRNA]