Protein name:
Protein JTB ;
Alternative:
Prostate androgen-regulated protein (PAR protein) ;Jumping translocation breakpoint protein ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts with AURKA, AURKB, BIRC5 and INCENP. May be a component of the CPC at least composed of BIRC5/survivin, CDCA8/borealin, INCENP and AURKB/Aurora-B.
Function:
Required for normal cytokinesis during mitosis. Plays a role in the regulation of cell proliferation. May be a component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Increases AURKB activity. Inhibits apoptosis induced by TGFB1 (By similarity). Overexpression induces swelling of mitochondria and reduces mitochondrial membrane potential.
Subcellular Location:
Membrane
Single-pass type I membrane protein
Mitochondrion
Cytoplasm
Cytoplasm
cytoskeleton
centrosome
Cytoplasm
cytoskeleton
spindle
Detected at the centrosome and along spindle fibers during prophase and metaphase. Detected at the midbody during telophase.
Protein Attributes:
50:
MLAGAGRPGL | PQGRHLCWLL | CAFTLKLCQA | EAPVQEEKLS | ASTSNLPCWL |
100:
VEEFVVAEEC | SPCSNFRAKT | TPECGPTGYV | EKITCSSSKR | NEFKSCRSAL |
146:
MEQRLFWKFE | GAVVCVALIF | ACLVIIRQRQ | LDRKALEKVR | KQIESI
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Rat
Mouse
Human
ELISA Kit for Human Protein JTB
ELISA Kit for Human Protein JTB
ELISA Kit for Human Protein JTB
CLIA Kit for Human Protein JTB
CLIA Kit for Human Protein JTB
CLIA Kit for Human Protein JTB
Polyclonal Antibody for Human Protein JTB
Polyclonal Antibody for Human Protein JTB
Polyclonal Antibody for Human Protein JTB
Monoclonal Antibody for Human Protein JTB
Monoclonal Antibody for Human Protein JTB
Monoclonal Antibody for Human Protein JTB
Protein for Human Protein JTB
Protein for Human Protein JTB
Protein for Human Protein JTB
R&D Technical Data
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Precision
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Recovery
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Linearity
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
9.
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Submitted (2005-09) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
tissue :
Cervix .
tissue :
Lung .
tissue :
Skin .
tissue :
Uterus .
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : TISSUE SPECIFICITY
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH AURKA; AURKB AND BIRC5;SUBUNIT;INDUCTION;TISSUE SPECIFICITY
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : STRUCTURE BY NMR OF 47-104