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Index > Protein center > JTB(Gene name) > Human
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  • JTB (Gene name),
  • Protein JTB (Protein name ),  JTB_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    JTB(HSPC222);
    Protein name:
    Protein JTB;
    Alternative:
    Prostate androgen-regulated protein(PAR protein);Jumping translocation breakpoint protein;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with AURKA, AURKB, BIRC5 and INCENP. May be a component of the CPC at least composed of BIRC5/survivin, CDCA8/borealin, INCENP and AURKB/Aurora-B.
    Function:
    Required for normal cytokinesis during mitosis. Plays a role in the regulation of cell proliferation. May be a component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Increases AURKB activity. Inhibits apoptosis induced by TGFB1 (By similarity). Overexpression induces swelling of mitochondria and reduces mitochondrial membrane potential.
    Subcellular Location:
    Membrane Single-pass type I membrane protein Mitochondrion Cytoplasm Cytoplasm cytoskeleton centrosome Cytoplasm cytoskeleton spindle Detected at the centrosome and along spindle fibers during prophase and metaphase. Detected at the midbody during telophase.
    Protein Attributes:
    Sequence length:
    146
    Sequence:
    50:
    MLAGAGRPGL | PQGRHLCWLL | CAFTLKLCQA | EAPVQEEKLS | ASTSNLPCWL | 
    100:
    VEEFVVAEEC | SPCSNFRAKT | TPECGPTGYV | EKITCSSSKR | NEFKSCRSAL | 
    146:
    MEQRLFWKFE | GAVVCVALIF | ACLVIIRQRQ | LDRKALEKVR | KQIESI
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    KEGG:
    MIM:
    SMR:
    Pfam:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Human Protein JTB
    ELISA Kit for Human Protein JTB
    ELISA Kit for Human Protein JTB
    CLIA Kit for Human Protein JTB
    CLIA Kit for Human Protein JTB
    CLIA Kit for Human Protein JTB
    Polyclonal Antibody for Human Protein JTB
    Polyclonal Antibody for Human Protein JTB
    Polyclonal Antibody for Human Protein JTB
    Monoclonal Antibody for Human Protein JTB
    Monoclonal Antibody for Human Protein JTB
    Monoclonal Antibody for Human Protein JTB
    Protein for Human Protein JTB
    Protein for Human Protein JTB
    Protein for Human Protein JTB

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "JTB: a novel membrane protein gene at 1q21 rearranged in a jumping translocation."
      Hatakeyama S. , Osawa M. , Omine M. , Ishikawa F.
      Oncogene18:2085-2090(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1);SUBCELLULAR LOCATION;TISSUE SPECIFICITY
    2. 2.
      "PAR, a novel androgen regulated gene, ubiquitously expressed in normal and malignant cells."
      Platica O. , Chen S. , Ivan E. , Lopingco M.C. , Holland J.F. , Platica M.
      Int. J. Oncol.16:1055-1061(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);TISSUE SPECIFICITY
      tissue: Mammary cancer.
      tissue: Prostatic carcinoma.
    3. 3.
      Mei G. , Yu W. , Gibbs R.A.
      Submitted (1999-02) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Brain.
    4. 4.
      "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
      Zhang Q.-H. , Ye M. , Wu X.-Y. , Ren S.-X. , Zhao M. , Zhao C.-J. , Fu G. , Shen Y. , Fan H.-Y. , Lu G. , Zhong M. , Xu X.-R. , Han Z.-G. , Zhang J.-W. , Tao J. , Huang Q.-H. , Zhou J. , Hu G.-X. , more...
      Genome Res.10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      tissue: Umbilical cord blood.
    5. 5.
      "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
      Submitted (2003-05) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
    6. 6.
      "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L. , Schick M. , Neubert P. , Schatten R. , Henze S. , Korn B.
      Submitted (2004-06) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
    7. 7.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Tongue.
    8. 8.
      "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G. , Barlow K.F. , McLay K.E. , Kaul R. , Swarbreck D. , Dunham A. , Scott C.E. , Howe K.L. , Woodfine K. , Spencer C.C.A. , Jones M.C. , Gillson C. , Searle S. , Zhou Y. , Kokocinski F. , McDonald L. , Evans R. , Phillips K. , more...
      Nature441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    9. 9.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    10. 10.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
      tissue: Cervix.
      tissue: Lung.
      tissue: Skin.
      tissue: Uterus.
    11. 11.
      "Characterization of Jumping translocation breakpoint (JTB) gene product isolated as a TGF-beta1-inducible clone involved in regulation of mitochondrial function, cell growth and cell death."
      Kanome T. , Itoh N. , Ishikawa F. , Mori K. , Kim-Kaneyama J.R. , Nose K. , Shibanuma M.
      Oncogene26:5991-6001(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
    12. 12.
      "PAR, a protein involved in the cell cycle, is functionally related to chromosomal passenger proteins."
      Platica M. , Ionescu A. , Ivan E. , Holland J.F. , Mandeli J. , Platica O.
      Int. J. Oncol.38:777-785(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH AURKA; AURKB AND BIRC5;SUBUNIT;INDUCTION;TISSUE SPECIFICITY
    13. 13.
      "The structure of the extracellular domain of the jumping translocation breakpoint protein reveals a variation of the midkine fold."
      Rousseau F. , Pan B. , Fairbrother W.J. , Bazan J.F. , Lingel A.
      J. Mol. Biol.415:22-28(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 47-104
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