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Index > Protein center > KCNA10(Gene name) > Human
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  • KCNA10 (Gene name),
  • Potassium voltage-gated channel subfamily A member 10 (Protein name ),  KCA10_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    KCNA10;
    Protein name:
    Potassium voltage-gated channel subfamily A member 10;
    Alternative:
    Voltage-gated potassium channel subunit Kv1.8;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Homotetramer. Interacts with KCN4B/POMP. Interaction with KCN4B/POMP is necessary for the modulation of channel activity by cAMP.
    Function:
    Mediates voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. The channel activity is up-regulated by cAMP.
    Subcellular Location:
    Membrane Multi-pass membrane protein
    Protein Attributes:
    Sequence length:
    511
    Sequence:
    50:
    MDVCGWKEME | VALVNFDNSD | EIQEEPGYAT | DFDSTSPKGR | PGGSSFSNGK | 
    100:
    ILISESTNHE | TAFSKLPGDY | ADPPGPEPVV | LNEGNQRVII | NIAGLRFETQ | 
    150:
    LRTLSQFPET | LLGDREKRMQ | FFDSMRNEYF | FDRNRPSFDG | ILYYYQSGGK | 
    200:
    IRRPANVPID | IFADEISFYE | LGSEAMDQFR | EDEGFIKDPE | TLLPTNDIHR | 
    250:
    QFWLLFEYPE | SSSAARAVAV | VSVLVVVISI | TIFCLETLPE | FREDRELKVV | 
    300:
    RDPNLNMSKT | VLSQTMFTDP | FFMVESTCIV | WFTFELVLRF | VVCPSKTDFF | 
    350:
    RNIMNIIDII | SIIPYFATLI | TELVQETEPS | AQQNMSLAIL | RIIRLVRVFR | 
    400:
    IFKLSRHSKG | LQILGQTLKA | SMRELGLLIF | FLFIGVILFS | SAVYFAEVDE | 
    450:
    PESHFSSIPD | GFWWAVVTMT | TVGYGDMCPT | TPGGKIVGTL | CAIAGVLTIA | 
    500:
    LPVPVIVSNF | NYFYHRETEN | EEKQNIPGEI | ERILNSVGSR | MGSTDSLNKT | 
    511:
    NGGCSTEKSR | K
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    Pfam:
    Pfam:
    KEGG:
    MIM:
    SMR:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Human Potassium voltage-gated channel subfamily A member 10
    ELISA Kit for Human Potassium voltage-gated channel subfamily A member 10
    CLIA Kit for Human Potassium voltage-gated channel subfamily A member 10
    CLIA Kit for Human Potassium voltage-gated channel subfamily A member 10
    Polyclonal Antibody for Human Potassium voltage-gated channel subfamily A member 10
    Polyclonal Antibody for Human Potassium voltage-gated channel subfamily A member 10
    Monoclonal Antibody for Human Potassium voltage-gated channel subfamily A member 10
    Monoclonal Antibody for Human Potassium voltage-gated channel subfamily A member 10
    Protein for Human Potassium voltage-gated channel subfamily A member 10
    Protein for Human Potassium voltage-gated channel subfamily A member 10

    R&D Technical Data
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    Precision
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    Recovery
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    References
    1. 1.
      "Genomic localization of the human gene for KCNA10, a cGMP-activated K channel."
      Orias M. , Bray-Ward P. , Curran M.E. , Keating M.T. , Desir G.V.
      Genomics42:33-37(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    2. 2.
      "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G. , Barlow K.F. , McLay K.E. , Kaul R. , Swarbreck D. , Dunham A. , Scott C.E. , Howe K.L. , Woodfine K. , Spencer C.C.A. , Jones M.C. , Gillson C. , Searle S. , Zhou Y. , Kokocinski F. , McDonald L. , Evans R. , Phillips K. , more...
      Nature441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    3. 3.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Lung.
    5. 5.
      "KCNA10: a novel ion channel functionally related to both voltage-gated potassium and CNG cation channels."
      Lang R. , Lee G. , Liu W. , Tian S. , Rafi H. , Orias M. , Segal A.S. , Desir G.V.
      Am. J. Physiol.278:F1013-F1021(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
    6. 6.
      "Regulation of the voltage-gated K+ channel KCNA10 by KCNA4B, a novel beta-subunit."
      Tian S. , Liu W. , Wu Y. , Rafi H. , Segal A.S. , Desir G.V.
      Am. J. Physiol.283:F142-F149(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH POMP;REGULATION BY CAMP
    7. 7.
      "Expression of KCNA10, a voltage-gated K channel, in glomerular endothelium and at the apical membrane of the renal proximal tubule."
      Yao X. , Tian S. , Chan H.-Y. , Biemesderfer D. , Desir G.V.
      J. Am. Soc. Nephrol.13:2831-2839(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
    8. 8.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT [LARGE SCALE ANALYSIS] HIS-200
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