Protein name:
Calcium-activated potassium channel subunit beta-1 ;
Alternative:
Calcium-activated potassium channel, subfamily M subunit beta-1 (Calcium-activated potassium channel subunit beta) ;BK channel subunit beta-1 (BKbeta;BKbeta1) ;K(VCA)beta-1 ;Charybdotoxin receptor subunit beta-1 ;Slo-beta-1 (Slo-beta) ;Maxi K channel subunit beta-1 ;
Organism:
Rabbit (Oryctolagus cuniculus).
General Annotation
Sub Unit:
Interacts with KCNMA1 tetramer. There are probably 4 molecules of KCMNB1 per KCNMA1 tetramer.
Function:
Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Increases the apparent Ca(2+)/voltage sensitivity of the KCNMA1 channel. It also modifies KCNMA1 channel kinetics and alters its pharmacological properties. It slows down the activation and the deactivation kinetics of the channel. Acts as a negative regulator of smooth muscle contraction by enhancing the calcium sensitivity to KCNMA1. Its presence is also a requirement for internal binding of the KCNMA1 channel opener dehydrosoyasaponin I (DHS-1) triterpene glycoside and for external binding of the agonist hormone 17-beta-estradiol (E2). Increases the binding activity of charybdotoxin (CTX) toxin to KCNMA1 peptide blocker by increasing the CTX association rate and decreasing the dissociation rate.
Subcellular Location:
Membrane
Multi-pass membrane protein
Protein Attributes:
50:
MGKKLVMAQK | RGETRALCLG | VAMVMCAVIT | YYILGTTMLP | LYQKSVWTQE |
100:
SLCRLIETNI | RDQEELEGKK | VPQYPCLWVN | VSAVGKWAVL | YHTEETRDRN |
150:
QQCSYIPGSL | DNYQMALADV | EKVRAKFHER | QVFYCFSTTQ | ENETSVLYQR |
191:
LYGPQALLAS | LFWPTFLLTG | GLLIIAMVKI | NRSLSILAAQ | K
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Rat
Rabbit
Human
Bovine
Dog
ELISA Kit for Rabbit Calcium-activated potassium channel subunit beta-1
ELISA Kit for Rabbit Calcium-activated potassium channel subunit beta-1
ELISA Kit for Rabbit Calcium-activated potassium channel subunit beta-1
ELISA Kit for Rabbit Calcium-activated potassium channel subunit beta-1
ELISA Kit for Rabbit Calcium-activated potassium channel subunit beta-1
ELISA Kit for Rabbit Calcium-activated potassium channel subunit beta-1
CLIA Kit for Rabbit Calcium-activated potassium channel subunit beta-1
CLIA Kit for Rabbit Calcium-activated potassium channel subunit beta-1
CLIA Kit for Rabbit Calcium-activated potassium channel subunit beta-1
CLIA Kit for Rabbit Calcium-activated potassium channel subunit beta-1
CLIA Kit for Rabbit Calcium-activated potassium channel subunit beta-1
CLIA Kit for Rabbit Calcium-activated potassium channel subunit beta-1
Polyclonal Antibody for Rabbit Calcium-activated potassium channel subunit beta-1
Polyclonal Antibody for Rabbit Calcium-activated potassium channel subunit beta-1
Polyclonal Antibody for Rabbit Calcium-activated potassium channel subunit beta-1
Polyclonal Antibody for Rabbit Calcium-activated potassium channel subunit beta-1
Polyclonal Antibody for Rabbit Calcium-activated potassium channel subunit beta-1
Polyclonal Antibody for Rabbit Calcium-activated potassium channel subunit beta-1
Monoclonal Antibody for Rabbit Calcium-activated potassium channel subunit beta-1
Monoclonal Antibody for Rabbit Calcium-activated potassium channel subunit beta-1
Monoclonal Antibody for Rabbit Calcium-activated potassium channel subunit beta-1
Monoclonal Antibody for Rabbit Calcium-activated potassium channel subunit beta-1
Monoclonal Antibody for Rabbit Calcium-activated potassium channel subunit beta-1
Monoclonal Antibody for Rabbit Calcium-activated potassium channel subunit beta-1
Protein for Rabbit Calcium-activated potassium channel subunit beta-1
Protein for Rabbit Calcium-activated potassium channel subunit beta-1
Protein for Rabbit Calcium-activated potassium channel subunit beta-1
Protein for Rabbit Calcium-activated potassium channel subunit beta-1
Protein for Rabbit Calcium-activated potassium channel subunit beta-1
Protein for Rabbit Calcium-activated potassium channel subunit beta-1
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
strain :
New Zealand white .
tissue :
Brain .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
tissue :
Skeletal muscle .
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
5.
"Cloning and characterization of large conductance Ca2+-activated K+ channel beta1 subunit in rabbit sphincter of Oddi."
Zhang X.
,
Wang S.
,
Wang Y.
,
Du P.
,
Wei J.
Submitted (2006-06) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
tissue :
Sphincter of Oddi .
6.
"Cloning and characterization of rabbit large conductance calcium activated potassium channel beta1 subunit gene and its promoter region."
Zhang X.
,
Wang S.
,
Yan Z.
,
Zhang Y.
,
Wei J.
Submitted (2006-07) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA]