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Index > Protein center > KCNA2(Gene name) > Human
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  • KCNA2 (Gene name),
  • Potassium voltage-gated channel subfamily A member 2 (Protein name ),  KCNA2_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    KCNA2;
    Protein name:
    Potassium voltage-gated channel subfamily A member 2;
    Alternative:
    Voltage-gated K(+) channel HuKIV;NGK1;Voltage-gated potassium channel subunit Kv1.2;Voltage-gated potassium channel HBK5;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Heterotetramer of potassium channel proteins. Binds PDZ domains of DLG1, DLG2 and DLG4.
    Function:
    Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.
    Subcellular Location:
    Membrane Multi-pass membrane protein
    Protein Attributes:
    Sequence length:
    499
    Sequence:
    50:
    MTVATGDPAD | EAAALPGHPQ | DTYDPEADHE | CCERVVINIS | GLRFETQLKT | 
    100:
    LAQFPETLLG | DPKKRMRYFD | PLRNEYFFDR | NRPSFDAILY | YYQSGGRLRR | 
    150:
    PVNVPLDIFS | EEIRFYELGE | EAMEMFREDE | GYIKEEERPL | PENEFQRQVW | 
    200:
    LLFEYPESSG | PARIIAIVSV | MVILISIVSF | CLETLPIFRD | ENEDMHGSGV | 
    250:
    TFHTYSNSTI | GYQQSTSFTD | PFFIVETLCI | IWFSFEFLVR | FFACPSKAGF | 
    300:
    FTNIMNIIDI | VAIIPYFITL | GTELAEKPED | AQQGQQAMSL | AILRVIRLVR | 
    350:
    VFRIFKLSRH | SKGLQILGQT | LKASMRELGL | LIFFLFIGVI | LFSSAVYFAE | 
    400:
    ADERESQFPS | IPDAFWWAVV | SMTTVGYGDM | VPTTIGGKIV | GSLCAIAGVL | 
    450:
    TIALPVPVIV | SNFNYFYHRE | TEGEEQAQYL | QVTSCPKIPS | SPDLKKSRSA | 
    499:
    STISKSDYME | IQEGVNNSNE | DFREENLKTA | NCTLANTNYV | NITKMLTDV
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    KEGG:
    SMR:
    UniGene:
    Pfam:
    Pfam:
    MIM:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Human Potassium voltage-gated channel subfamily A member 2
    ELISA Kit for Human Potassium voltage-gated channel subfamily A member 2
    ELISA Kit for Human Potassium voltage-gated channel subfamily A member 2
    ELISA Kit for Human Potassium voltage-gated channel subfamily A member 2
    ELISA Kit for Human Potassium voltage-gated channel subfamily A member 2
    CLIA Kit for Human Potassium voltage-gated channel subfamily A member 2
    CLIA Kit for Human Potassium voltage-gated channel subfamily A member 2
    CLIA Kit for Human Potassium voltage-gated channel subfamily A member 2
    CLIA Kit for Human Potassium voltage-gated channel subfamily A member 2
    CLIA Kit for Human Potassium voltage-gated channel subfamily A member 2
    Polyclonal Antibody for Human Potassium voltage-gated channel subfamily A member 2
    Polyclonal Antibody for Human Potassium voltage-gated channel subfamily A member 2
    Polyclonal Antibody for Human Potassium voltage-gated channel subfamily A member 2
    Polyclonal Antibody for Human Potassium voltage-gated channel subfamily A member 2
    Polyclonal Antibody for Human Potassium voltage-gated channel subfamily A member 2
    Monoclonal Antibody for Human Potassium voltage-gated channel subfamily A member 2
    Monoclonal Antibody for Human Potassium voltage-gated channel subfamily A member 2
    Monoclonal Antibody for Human Potassium voltage-gated channel subfamily A member 2
    Monoclonal Antibody for Human Potassium voltage-gated channel subfamily A member 2
    Monoclonal Antibody for Human Potassium voltage-gated channel subfamily A member 2
    Protein for Human Potassium voltage-gated channel subfamily A member 2
    Protein for Human Potassium voltage-gated channel subfamily A member 2
    Protein for Human Potassium voltage-gated channel subfamily A member 2
    Protein for Human Potassium voltage-gated channel subfamily A member 2
    Protein for Human Potassium voltage-gated channel subfamily A member 2

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Human potassium channel genes: molecular cloning and functional expression."
      Ramaswami M. , Gautam M. , Kamb A. , Rudy B. , Tanouye M.A. , Mathew M.K.
      Mol. Cell. Neurosci.1:214-223(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION;SUBCELLULAR LOCATION;ENZYME REGULATION
      tissue: Brain.
    2. 2.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Substantia nigra.
    3. 3.
      "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G. , Barlow K.F. , McLay K.E. , Kaul R. , Swarbreck D. , Dunham A. , Scott C.E. , Howe K.L. , Woodfine K. , Spencer C.C.A. , Jones M.C. , Gillson C. , Searle S. , Zhou Y. , Kokocinski F. , McDonald L. , Evans R. , Phillips K. , more...
      Nature441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 4.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      tissue: Blood.
    6. 6.
      "Heteromultimeric assembly of human potassium channels. Molecular basis of a transient outward current?"
      Po S. , Roberds S. , Snyders D.J. , Tamkun M.M. , Bennett P.B.
      Circ. Res.72:1326-1336(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;SUBUNIT;INTERACTION WITH KCNA4
    7. 7.
      "Caspr2, a new member of the neurexin superfamily, is localized at the juxtaparanodes of myelinated axons and associates with K+ channels."
      Poliak S. , Gollan L. , Martinez R. , Custer A. , Einheber S. , Salzer J.L. , Trimmer J.S. , Shrager P. , Peles E.
      Neuron24:1037-1047(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CNTNAP2
    8. 8.
      "Role of receptor protein tyrosine phosphatase alpha (RPTPalpha) and tyrosine phosphorylation in the serotonergic inhibition of voltage-dependent potassium channels."
      Imbrici P. , Tucker S.J. , D'Adamo M.C. , Pessia M.
      Pflugers Arch.441:257-262(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
    9. 9.
      "Subunit composition and novel localization of K+ channels in spinal cord."
      Rasband M.N. , Trimmer J.S.
      J. Comp. Neurol.429:166-176(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;INTERACTION WITH KCNA1 AND KCNAB2;SUBUNIT;TISSUE SPECIFICITY
    10. 10.
      "Voltage-gated ion channels in the axon initial segment of human cortical pyramidal cells and their relationship with chandelier cells."
      Inda M.C. , DeFelipe J. , Munoz A.
      Proc. Natl. Acad. Sci. U.S.A.103:2920-2925(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;TISSUE SPECIFICITY
    11. 11.
      "The molecular basis for the actions of KVbeta1.2 on the opening and closing of the KV1.2 delayed rectifier channel."
      Peters C.J. , Vaid M. , Horne A.J. , Fedida D. , Accili E.A.
      Channels3:314-322(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH KCNAB1
    12. 12.
      "Biochemical characterization of kappaM-RIIIJ, a Kv1.2 channel blocker: evaluation of cardioprotective effects of kappaM-conotoxins."
      Chen P. , Dendorfer A. , Finol-Urdaneta R.K. , Terlau H. , Olivera B.M.
      J. Biol. Chem.285:14882-14889(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;SUBUNIT;ENZYME REGULATION
    13. 13.
      "Altered distribution of juxtaparanodal kv1.2 subunits mediates peripheral nerve hyperexcitability in type 2 diabetes mellitus."
      Zenker J. , Poirot O. , de Preux Charles A.S. , Arnaud E. , Medard J.J. , Lacroix C. , Kuntzer T. , Chrast R.
      J. Neurosci.32:7493-7498(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
    14. 14.
      "Activation of lysophosphatidic acid receptor by gintonin inhibits Kv1.2 channel activity: involvement of tyrosine kinase and receptor protein tyrosine phosphatase alpha."
      Lee J.H. , Choi S.H. , Lee B.H. , Hwang S.H. , Kim H.J. , Rhee J. , Chung C. , Nah S.Y.
      Neurosci. Lett.548:143-148(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
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