KCNA5 ELISA Kit for Human(Homo sapiens) | EIAab.comKCNA5 ELISA Kit for Human(Homo sapiens)

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KCNA5 (Gene name),

Potassium voltage-gated channel subfamily A member 5 (Protein name ), KCNA5_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

KCNA5;

Protein name:

Potassium voltage-gated channel subfamily A member 5;

Alternative:

Voltage-gated potassium channel HK2;HPCN1;Voltage-gated potassium channel subunit Kv1.5;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Heterotetramer of potassium channel proteins. Interacts with DLG1, which enhances channel currents. Forms a ternary complex with DLG1 and CAV3 (By similarity). Interacts with UBE2I.

Function:

Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. This channel displays rapid activation and slow inactivation. May play a role in regulating the secretion of insulin in normal pancreatic islets. Isoform 2 exhibits a voltage-dependent recovery from inactivation and an excessive cumulative inactivation.

Subcellular Location:

Membrane Multi-pass membrane protein

Protein Attributes:

Sequence length:

613

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

613:

YALCLDTSRE | TDL

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Hs.150208

String:

P22460

MIM:

176267

SMR:

P22460

KEGG:

hsa:3741

Pfam:

PF00520

Pfam:

PF02214

STRING:

9606.ENSP00000252321

Uniprot:

P22460

FOR

ELISA Kit for Human Potassium voltage-gated channel subfamily A member 5

CLIA Kit for Human Potassium voltage-gated channel subfamily A member 5

Polyclonal Antibody for Human Potassium voltage-gated channel subfamily A member 5

Monoclonal Antibody for Human Potassium voltage-gated channel subfamily A member 5

Protein for Human Potassium voltage-gated channel subfamily A member 5

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Molecular cloning and characterization of two voltage-gated K+ channel cDNAs from human ventricle."
Tamkun M.M. , Knoth K.M. , Walbridge J.A. , Kroemer H. , Roden D.M. , Glover D.M.
FASEB J.5:331-337(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue: Heart.
2.

"Sequence and functional expression in Xenopus oocytes of a human insulinoma and islet potassium channel."
Philipson L.H. , Hice R.E. , Schaefer K. , Lamendola J. , Bell G.I. , Nelson D.J. , Steiner D.F.
Proc. Natl. Acad. Sci. U.S.A.88:53-57(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue: Insulinoma.
3.

"Molecular cloning, characterization, and genomic localization of a human potassium channel gene."
Curran M.E. , Landes G.M. , Keating M.T.
Genomics12:729-737(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue: Heart.
4.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
5.

"A rapidly activating and slowly inactivating potassium channel cloned from human heart. Functional analysis after stable mammalian cell culture expression."
Snyders D.J. , Tamkun M.M. , Bennett P.B.
J. Gen. Physiol.101:513-543(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
6.

"Altered state dependence of c-type inactivation in the long and short forms of human Kv1.5."
Kurata H.T. , Soon G.S. , Fedida D.
J. Gen. Physiol.118:315-332(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;ALTERNATIVE SPLICING (ISOFORMS 1 AND 2)
7.

"A specific N-terminal residue in Kv1.5 is required for upregulation of the channel by SAP97."
Mathur R. , Choi W.S. , Eldstrom J. , Wang Z. , Kim J. , Steele D.F. , Fedida D.
Biochem. Biophys. Res. Commun.342:1-8(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH DLG1;MUTAGENESIS OF THR-15
8.

"Kv1.5 channelopathy due to KCNA5 loss-of-function mutation causes human atrial fibrillation."
Olson T.M. , Alekseev A.E. , Liu X.K. , Park S. , Zingman L.V. , Bienengraeber M. , Sattiraju S. , Ballew J.D. , Jahangir A. , Terzic A.
Hum. Mol. Genet.15:2185-2191(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN ATFB7
9.

"SUMO modification regulates inactivation of the voltage-gated potassium channel Kv1.5."
Benson M.D. , Li Q.J. , Kieckhafer K. , Dudek D. , Whorton M.R. , Sunahara R.K. , Iniguez-Lluhi J.A. , Martens J.R.
Proc. Natl. Acad. Sci. U.S.A.104:1805-1810(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUMOYLATION AT LYS-221 AND LYS-536;INTERACTION WITH UBE2I;MUTAGENESIS OF ILE-220; LYS-221; LEU-535 AND LYS-536
10.

"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T. , Jones S. , Wood L.D. , Parsons D.W. , Lin J. , Barber T.D. , Mandelker D. , Leary R.J. , Ptak J. , Silliman N. , Szabo S. , Buckhaults P. , Farrell C. , Meeh P. , Markowitz S.D. , Willis J. , Dawson D. , Willson J.K.V. , more...
Science314:268-274(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT [LARGE SCALE ANALYSIS] SER-300

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