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Index > Protein center > Kcnd2(Gene name) > Mouse
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  • Kcnd2 (Gene name),
  • Potassium voltage-gated channel subfamily D member 2 (Protein name ),  KCND2_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Kcnd2(MNCb-7013;Kiaa1044);
    Protein name:
    Potassium voltage-gated channel subfamily D member 2;
    Alternative:
    Voltage-gated potassium channel subunit Kv4.2;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Homotetramer or heterotetramer with KCND1 and/or KCND3. Associates with the regulatory subunits KCNIP1, KCNIP2, KCNIP3 and KCNIP4. Probably part of a complex consisting of KCNIP1, KCNIP2 isoform 3 and KCND2. The KCND2-KCNIP2 channel complex contains four KCND2 and four KCNIP2 subunits. Interacts with DPP6, DPP10, DLG4, NCS1/FREQ, FLNA, FLNC and DLG1.
    Function:
    Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits.
    Subcellular Location:
    Membrane Multi-pass membrane protein
    Protein Attributes:
    Sequence length:
    630
    Sequence:
    50:
    MAAGVAAWLP | FARAAAIGWM | PVASGPMPAP | PRQERKRTQD | ALIVLNVSGT | 
    100:
    RFQTWQDTLE | RYPDTLLGSS | ERDFFYHPET | QQYFFDRDPD | IFRHILNFYR | 
    150:
    TGKLHYPRHE | CISAYDEELA | FFGLIPEIIG | DCCYEEYKDR | RRENAERLQD | 
    200:
    DADTDNTGES | ALPTMTARQR | VWRAFENPHT | STMALVFYYV | TGFFIAVSVI | 
    250:
    ANVVETVPCG | SSPGHIKELP | CGERYAVAFF | CLDTACVMIF | TVEYLLRLAA | 
    300:
    APSRYRFVRS | VMSIIDVVAI | LPYYIGLVMT | DNEDVSGAFV | TLRVFRVFRI | 
    350:
    FKFSRHSQGL | RILGYTLKSC | ASELGFLLFS | LTMAIIIFAT | VMFYAEKGSS | 
    400:
    ASKFTSIPAA | FWYTIVTMTT | LGYGDMVPKT | IAGKIFGSIC | SLSGVLVIAL | 
    450:
    PVPVIVSNFS | RIYHQNQRAD | KRRAQKKARL | ARIRAAKSGS | ANAYMQSKRN | 
    500:
    GLLSNQLQSS | EDEPAFISKS | GSSFETQHHH | LLHCLEKTTN | HEFVDEQVFE | 
    550:
    ESCMEVATVN | RPSSHSPSLS | SQQGVTSTCC | SRRHKKTFRI | PNANVSGSHR | 
    600:
    GSVQELSTIQ | IRCVERTPLS | NSRSSLNAKM | EECVKLNCEQ | PYVTTAIISI | 
    630:
    PTPPVTTPEG | DDRPESPEYS | GGNIVRVSAL | 
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    Pfam:
    KEGG:
    UniGene:
    Pfam:
    SMR:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Potassium voltage-gated channel subfamily D member 2
    ELISA Kit for Mouse Potassium voltage-gated channel subfamily D member 2
    ELISA Kit for Mouse Potassium voltage-gated channel subfamily D member 2
    ELISA Kit for Mouse Potassium voltage-gated channel subfamily D member 2
    CLIA Kit for Mouse Potassium voltage-gated channel subfamily D member 2
    CLIA Kit for Mouse Potassium voltage-gated channel subfamily D member 2
    CLIA Kit for Mouse Potassium voltage-gated channel subfamily D member 2
    CLIA Kit for Mouse Potassium voltage-gated channel subfamily D member 2
    Polyclonal Antibody for Mouse Potassium voltage-gated channel subfamily D member 2
    Polyclonal Antibody for Mouse Potassium voltage-gated channel subfamily D member 2
    Polyclonal Antibody for Mouse Potassium voltage-gated channel subfamily D member 2
    Polyclonal Antibody for Mouse Potassium voltage-gated channel subfamily D member 2
    Monoclonal Antibody for Mouse Potassium voltage-gated channel subfamily D member 2
    Monoclonal Antibody for Mouse Potassium voltage-gated channel subfamily D member 2
    Monoclonal Antibody for Mouse Potassium voltage-gated channel subfamily D member 2
    Monoclonal Antibody for Mouse Potassium voltage-gated channel subfamily D member 2
    Protein for Mouse Potassium voltage-gated channel subfamily D member 2
    Protein for Mouse Potassium voltage-gated channel subfamily D member 2
    Protein for Mouse Potassium voltage-gated channel subfamily D member 2
    Protein for Mouse Potassium voltage-gated channel subfamily D member 2

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Cloning and functional characterization of mouse heart K+ channel alpha subunits, Kv1.5, Kv4.2 and Kv4.3."
      Tanaka H. , Janzen K. , Winkfein R.J. , Fiset C. , Clark R.B. , Giles W.R.
      Submitted (1998-11) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      strain: Swiss Webster.
      tissue: Heart ventricle.
    2. 2.
      "Isolation of full-length cDNA clones from mouse brain cDNA library made by oligo-capping method."
      Osada N. , Kusuda J. , Tanuma R. , Ito A. , Hirata M. , Sugano S. , Hashimoto K.
      Submitted (2000-06) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: C57BL/6.
      tissue: Brain.
    3. 3.
      "Prediction of the coding sequences of mouse homologues of KIAA gene: I. The complete nucleotide sequences of 100 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
      Okazaki N. , Kikuno R. , Ohara R. , Inamoto S. , Hara Y. , Nagase T. , Ohara O. , Koga H.
      DNA Res.9:179-188(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Brain.
    4. 4.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: C57BL/6J.
      tissue: Mesonephros.
      tissue: Olfactory bulb.
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: C57BL/6.
      tissue: Brain.
    6. 6.
      "Kv4.2 phosphorylation by cyclic AMP-dependent protein kinase."
      Anderson A.E. , Adams J.P. , Qian Y. , Cook R.G. , Pfaffinger P.J. , Sweatt J.D.
      J. Biol. Chem.275:5337-5346(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT THR-38 AND SER-552 BY PKACA
    7. 7.
      "The A-type potassium channel Kv4.2 is a substrate for the mitogen-activated protein kinase ERK."
      Adams J.P. , Anderson A.E. , Varga A.W. , Dineley K.T. , Cook R.G. , Pfaffinger P.J. , Sweatt J.D.
      J. Neurochem.75:2277-2287(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT THR-602; THR-607 AND SER-616
    8. 8.
      "Input-specific immunolocalization of differentially phosphorylated Kv4.2 in the mouse brain."
      Varga A.W. , Anderson A.E. , Adams J.P. , Vogel H. , Sweatt J.D.
      Learn. Memory7:321-332(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION;TISSUE SPECIFICITY
    9. 9.
      "PKA modulation of Kv4.2-encoded A-type potassium channels requires formation of a supramolecular complex."
      Schrader L.A. , Anderson A.E. , Mayne A. , Pfaffinger P.J. , Sweatt J.D.
      J. Neurosci.22:10123-10133(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH KCNIP3;MUTAGENESIS OF SER-552;PHOSPHORYLATION AT SER-552
    10. 10.
      "Role of heteromultimers in the generation of myocardial transient outward K+ currents."
      Guo W. , Li H. , Aimond F. , Johns D.C. , Rhodes K.J. , Trimmer J.S. , Nerbonne J.M.
      Circ. Res.90:586-593(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH KCND3 AND KCNIP2
    11. 11.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH KCNIP4
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