KCNE2 ELISA Kit for Human(Homo sapiens) | EIAab.comKCNE2 ELISA Kit for Human(Homo sapiens)

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KCNE2 (Gene name),

Potassium voltage-gated channel subfamily E member 2 (Protein name ), KCNE2_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

KCNE2;

Protein name:

Potassium voltage-gated channel subfamily E member 2;

Alternative:

Minimum potassium ion channel-related peptide 1;MinK-related peptide 1;Potassium channel subunit beta MiRP1;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Associates with KCNH2/ERG1. May associate with KCNQ1/KVLQT1, KCNQ2 and KCNQ3. Associates with HCN1 and probably HCN2.

Function:

Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Associated with KCNH2/HERG is proposed to form the rapidly activating component of the delayed rectifying potassium current in heart (IKr). May associate with KCNQ2 and/or KCNQ3 and modulate the native M-type current. May associate with KCNQ1/KVLTQ1 and elicit a voltage-independent current. May associate with HCN1 and HCN2 and increase potassium current.

Subcellular Location:

Membrane Single-pass type I membrane protein

Protein Attributes:

Sequence length:

123

Sequence:

50:

100:

123:

LNLEESKATI | HENIGAAGFK | MSP

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

Q9Y6J6

UniGene:

Hs.551521

Pfam:

PF02060

String:

Q9Y6J6

STRING:

9606.ENSP00000290310

KEGG:

hsa:9992

MIM:

603796

Uniprot:

Q9Y6J6

FOR

ELISA Kit for Human Potassium voltage-gated channel subfamily E member 2

CLIA Kit for Human Potassium voltage-gated channel subfamily E member 2

Polyclonal Antibody for Human Potassium voltage-gated channel subfamily E member 2

Monoclonal Antibody for Human Potassium voltage-gated channel subfamily E member 2

Protein for Human Potassium voltage-gated channel subfamily E member 2

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"MiRP1 forms IKr potassium channels with HERG and is associated with cardiac arrhythmia."
Abbott G.W. , Sesti F. , Splawski I. , Buck M.E. , Lehmann M.H. , Timothy K.W. , Keating M.T. , Goldstein S.A.N.
Cell97:175-187(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANTS LQT6 GLU-9; THR-54 AND THR-57;VARIANT ALA-8;INTERACTION WITH KCNH2
tissue: Heart.
2.

"Cloning of human MIRP1 cDNA."
Domenech A. , Estivill X. , de la Luna S.
Submitted (2000-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
3.

NHLBI resequencing and genotyping service (RS&G)
Submitted (2006-06) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
4.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
6.

"M-type KCNQ2-KCNQ3 potassium channels are modulated by the KCNE2 subunit."
Tinel N. , Diochot S. , Lauritzen I. , Barhanin J. , Lazdunski M. , Borsotto M.
FEBS Lett.480:137-141(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ASSOCIATION WITH KCNQ2/KCNQ3;TISSUE SPECIFICITY
7.

"KCNE2 confers background current characteristics to the cardiac KCNQ1 potassium channel."
Tinel N. , Diochot S. , Borsotto M. , Lazdunski M. , Barhanin J.
EMBO J.19:6326-6330(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ASSOCIATION WITH KCNQ1
8.

"Disease-associated mutations in KCNE potassium channel subunits (MiRPs) reveal promiscuous disruption of multiple currents and conservation of mechanism."
Abbott G.W. , Goldstein S.A.N.
FASEB J.16:390-400(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF LYS-75
9.

"Identification and functional characterization of a novel KCNE2 (MiRP1) mutation that alters HERG channel kinetics."
Isbrandt D. , Friederich P. , Solth A. , Haverkamp W. , Ebneth A. , Borggrefe M. , Funke H. , Sauter K. , Breithardt G. , Pongs O. , Schulze-Bahr E.
J. Mol. Med.80:524-532(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT LQT6 MET-65
10.

"Identification of a KCNE2 gain-of-function mutation in patients with familial atrial fibrillation."
Yang Y. , Xia M. , Jin Q. , Bendahhou S. , Shi J. , Chen Y. , Liang B. , Lin J. , Liu Y. , Liu B. , Zhou Q. , Zhang D. , Wang R. , Ma N. , Su X. , Niu K. , Pei Y. , Xu W. , more...
Am. J. Hum. Genet.75:899-905(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT ATFB4 CYS-27;CHARACTERIZATION OF VARIANT ATFB4 CYS-27
11.

"Spectrum of pathogenic mutations and associated polymorphisms in a cohort of 44 unrelated patients with long QT syndrome."
Millat G. , Chevalier P. , Restier-Miron L. , Da Costa A. , Bouvagnet P. , Kugener B. , Fayol L. , Gonzalez Armengod C. , Oddou B. , Chanavat V. , Froidefond E. , Perraudin R. , Rousson R. , Rodriguez-Lafrasse C.
Clin. Genet.70:214-227(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS LQT6 THR-57; LEU-60 AND TRP-77;VARIANT ALA-8

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