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Index > Protein center > Kcnh2(Gene name) > Mouse
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  • Kcnh2 (Gene name),
  • Potassium voltage-gated channel subfamily H member 2 (Protein name ),  KCNH2_MOUSE from NCBI database.
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  • Gene name:
    Kcnh2(Erg;Merg1);
    Protein name:
    Potassium voltage-gated channel subfamily H member 2;
    Alternative:
    Voltage-gated potassium channel subunit Kv11.1;Ether-a-go-go-related gene potassium channel 1(ERG-1;Eag-related protein 1;Ether-a-go-go-related protein 1;MERG);
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits. Heteromultimer with KCNH6/ERG2, KCNH7/ERG3, KCNE1 and KCNE2. Interacts with ALG10B.
    Function:
    Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Channel properties are modulated by cAMP and subunit assembly. Mediates the rapidly activating component of the delayed rectifying potassium current in heart (IKr).
    Subcellular Location:
    Membrane Multi-pass membrane protein
    Protein Attributes:
    Sequence length:
    1162
    Sequence:
    50:
    MPVRRGHVAP | QNTFLDTIIR | KFEGQSRKFI | IANARVENCA | VIYCNDGFCE | 
    100:
    LCGYSRAEVM | QRPCTCDFLH | GPRTQRRAAA | QIAQALLGAE | ERKVEIAFYR | 
    150:
    KDGSCFLCLV | DVVPVKNEDG | AVIMFILNFE | VVMEKDMVGS | PAHDTNHRGP | 
    200:
    STSWLASGRA | KTFRLKLPAL | LALTARESSV | RTGSMHSAGA | PGAVVVDVDL | 
    250:
    TPAAPSSESL | ALDEVSAMDN | HVAGLGPAEE | RRALVGPGSA | SPVASIRGPH | 
    300:
    PSPRAQSLNP | DASGSSCSLA | RTRSRESCAS | VRRASSADDI | EAMRAGALPP | 
    350:
    PPRHASTGAM | HPLRSGLLNS | TSDSDLVRYR | TISKIPQITL | NFVDLKGDPF | 
    400:
    LASPTSDREI | IAPKIKERTH | NVTEKVTQVL | SLGADVLPEY | KLQAPRIHRW | 
    450:
    TILHYSPFKA | VWDWLILLLV | IYTAVFTPYS | AAFLLKETED | GSQAPDCGYA | 
    500:
    CQPLAVVDLI | VDIMFIVDIL | INFRTTYVNA | NEEVVSHPGR | IAVHYFKGWF | 
    550:
    LIDMVAAIPF | DLLIFGSGSE | ELIGLLKTAR | LLRLVRVARK | LDRYSEYGAA | 
    600:
    VLFLLMCTFA | LIAHWLACIW | YAIGNMEQPH | MDSHIGWLHN | LGDQIGKPYN | 
    650:
    SSGLGGPSIK | DKYVTALYFT | FSSLTSVGFG | NVSPNTNSEK | IFSICVMLIG | 
    700:
    SLMYASIFGN | VSAIIQRLYS | GTARYHTQML | RVREFIRFHQ | IPNPLRQRLE | 
    750:
    EYFQHAWSYT | NGIDMNAVLK | GFPECLQADI | CLHLNRSLLQ | HCKPFRGATK | 
    800:
    GCLRALAMKF | KTTHAPPGDT | LVHAGDLLTA | LYFISRGSIE | ILRGDVVVAI | 
    850:
    LGKNDIFGEP | LNLYARPGKS | NGDVRALTYC | DLHKIHRDDL | LEVLDMYPEF | 
    900:
    SDHFWSSLEI | TFNLRDTNMI | PGSPGSAELE | SGFNRQRKRK | LSFRRRTDKD | 
    950:
    TEQPGEVSAL | GQGPARVGPG | PSCRGQPGGP | WGESPSSGPS | SPESSEDEGP | 
    1000:
    GRSSSPLRLV | PFSSPRPPGD | PPGGEPLTED | GEKSDTCNPL | SGAFSGVSNI | 
    1050:
    FSFWGDSRGR | QYQELPRCPA | PAPSLLNIPL | SSPGRRSRGD | VESRLDALQR | 
    1100:
    QLNRLETRLS | ADMATVLQLL | QRQMTLVPPA | YSAVTTPGPG | PTSASPLLPV | 
    1150:
    GPVPTLTLDS | LSQVSQFVAF | EELPAGAPEL | PQDGPTRRLS | LPGQLGALTS | 
    1162:
    QPLHRHGSDP | GS
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    Pfam:
    UniGene:
    SMR:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Potassium voltage-gated channel subfamily H member 2
    ELISA Kit for Mouse Potassium voltage-gated channel subfamily H member 2
    ELISA Kit for Mouse Potassium voltage-gated channel subfamily H member 2
    ELISA Kit for Mouse Potassium voltage-gated channel subfamily H member 2
    ELISA Kit for Mouse Potassium voltage-gated channel subfamily H member 2
    ELISA Kit for Mouse Potassium voltage-gated channel subfamily H member 2
    ELISA Kit for Mouse Potassium voltage-gated channel subfamily H member 2
    CLIA Kit for Mouse Potassium voltage-gated channel subfamily H member 2
    CLIA Kit for Mouse Potassium voltage-gated channel subfamily H member 2
    CLIA Kit for Mouse Potassium voltage-gated channel subfamily H member 2
    CLIA Kit for Mouse Potassium voltage-gated channel subfamily H member 2
    CLIA Kit for Mouse Potassium voltage-gated channel subfamily H member 2
    CLIA Kit for Mouse Potassium voltage-gated channel subfamily H member 2
    CLIA Kit for Mouse Potassium voltage-gated channel subfamily H member 2
    Polyclonal Antibody for Mouse Potassium voltage-gated channel subfamily H member 2
    Polyclonal Antibody for Mouse Potassium voltage-gated channel subfamily H member 2
    Polyclonal Antibody for Mouse Potassium voltage-gated channel subfamily H member 2
    Polyclonal Antibody for Mouse Potassium voltage-gated channel subfamily H member 2
    Polyclonal Antibody for Mouse Potassium voltage-gated channel subfamily H member 2
    Polyclonal Antibody for Mouse Potassium voltage-gated channel subfamily H member 2
    Polyclonal Antibody for Mouse Potassium voltage-gated channel subfamily H member 2
    Monoclonal Antibody for Mouse Potassium voltage-gated channel subfamily H member 2
    Monoclonal Antibody for Mouse Potassium voltage-gated channel subfamily H member 2
    Monoclonal Antibody for Mouse Potassium voltage-gated channel subfamily H member 2
    Monoclonal Antibody for Mouse Potassium voltage-gated channel subfamily H member 2
    Monoclonal Antibody for Mouse Potassium voltage-gated channel subfamily H member 2
    Monoclonal Antibody for Mouse Potassium voltage-gated channel subfamily H member 2
    Monoclonal Antibody for Mouse Potassium voltage-gated channel subfamily H member 2
    Protein for Mouse Potassium voltage-gated channel subfamily H member 2
    Protein for Mouse Potassium voltage-gated channel subfamily H member 2
    Protein for Mouse Potassium voltage-gated channel subfamily H member 2
    Protein for Mouse Potassium voltage-gated channel subfamily H member 2
    Protein for Mouse Potassium voltage-gated channel subfamily H member 2
    Protein for Mouse Potassium voltage-gated channel subfamily H member 2
    Protein for Mouse Potassium voltage-gated channel subfamily H member 2

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    Precision
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    Linearity
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    References
    1. 1.
      "Two isoforms of the mouse ether-a-go-go-related gene coassemble to form channels with properties similar to the rapidly activating component of the cardiac delayed rectifier K+ current."
      London B. , Trudeau M.C. , Newton K.P. , Beyer A.K. , Copeland N.G. , Gilbert D.J. , Jenkins N.A. , Satler C.A. , Robertson G.A.
      Circ. Res.81:870-878(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1; 2 AND 3);VARIANTS ARG-186; THR-455; TYR-752 AND ASN-1006
      strain: 129/Sv.
      strain: BALB/c.
      tissue: Heart.
    2. 2.
      "Electrophysiological characterization of an alternatively processed ERG K+ channel in mouse and human hearts."
      Lees-Miller J.P. , Kondo C. , Wang L. , Duff H.J.
      Circ. Res.81:719-726(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 3)
      tissue: Atrial tumor.
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