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Index > Protein center > KCNQ5(Gene name) > Human
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  • KCNQ5 (Gene name),
  • Potassium voltage-gated channel subfamily KQT member 5 (Protein name ),  KCNQ5_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    KCNQ5;
    Protein name:
    Potassium voltage-gated channel subfamily KQT member 5;
    Alternative:
    Potassium channel subunit alpha KvLQT5;KQT-like 5;Voltage-gated potassium channel subunit Kv7.5;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Heteromultimer with KCNQ3.
    Function:
    Probably important in the regulation of neuronal excitability. Associates with KCNQ3 to form a potassium channel which contributes to M-type current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons. May contribute, with other potassium channels, to the molecular diversity of an heterogeneous population of M-channels, varying in kinetic and pharmacological properties, which underlie this physiologically important current. Insensitive to tetraethylammonium, but inhibited by barium, linopirdine and XE991. Activated by niflumic acid and the anticonvulsant retigabine. Muscarine suppresses KCNQ5 current in Xenopus oocytes in which cloned KCNQ5 channels were coexpressed with M(1) muscarinic receptors.
    Subcellular Location:
    Membrane Multi-pass membrane protein
    Protein Attributes:
    Sequence length:
    932
    Sequence:
    50:
    MPRHHAGGEE | GGAAGLWVKS | GAAAAAAGGG | RLGSGMKDVE | SGRGRVLLNS | 
    100:
    AAARGDGLLL | LGTRAATLGG | GGGGLRESRR | GKQGARMSLL | GKPLSYTSSQ | 
    150:
    SCRRNVKYRR | VQNYLYNVLE | RPRGWAFIYH | AFVFLLVFGC | LILSVFSTIP | 
    200:
    EHTKLASSCL | LILEFVMIVV | FGLEFIIRIW | SAGCCCRYRG | WQGRLRFARK | 
    250:
    PFCVIDTIVL | IASIAVVSAK | TQGNIFATSA | LRSLRFLQIL | RMVRMDRRGG | 
    300:
    TWKLLGSVVY | AHSKELITAW | YIGFLVLIFS | SFLVYLVEKD | ANKEFSTYAD | 
    350:
    ALWWGTITLT | TIGYGDKTPL | TWLGRLLSAG | FALLGISFFA | LPAGILGSGF | 
    400:
    ALKVQEQHRQ | KHFEKRRNPA | ANLIQCVWRS | YAADEKSVSI | ATWKPHLKAL | 
    450:
    HTCSPTKKEQ | GEASSSQKLS | FKERVRMASP | RGQSIKSRQA | SVGDRRSPST | 
    500:
    DITAEGSPTK | VQKSWSFNDR | TRFRPSLRLK | SSQPKPVIDA | DTALGTDDVY | 
    550:
    DEKGCQCDVS | VEDLTPPLKT | VIRAIRIMKF | HVAKRKFKET | LRPYDVKDVI | 
    600:
    EQYSAGHLDM | LCRIKSLQTR | VDQILGKGQI | TSDKKSREKI | TAEHETTDDL | 
    650:
    SMLGRVVKVE | KQVQSIESKL | DCLLDIYQQV | LRKGSASALA | LASFQIPPFE | 
    700:
    CEQTSDYQSP | VDSKDLSGSA | QNSGCLSRST | SANISRGLQF | ILTPNEFSAQ | 
    750:
    TFYALSPTMH | SQATQVPISQ | SDGSAVAATN | TIANQINTAP | KPAAPTTLQI | 
    800:
    PPPLPAIKHL | PRPETLHPNP | AGLQESISDV | TTCLVASKEN | VQVAQSNLTK | 
    850:
    DRSMRKSFDM | GGETLLSVCP | MVPKDLGKSL | SVQNLIRSTE | ELNIQLSGSE | 
    900:
    SSGSRGSQDF | YPKWRESKLF | ITDEEVGPEE | TETDTFDAAP | QPAREAAFAS | 
    932:
    DSLRTGRSRS | SQSICKAGES | TDALSLPHVK | LK
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    MIM:
    UniGene:
    String:
    Pfam:
    SMR:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human Potassium voltage-gated channel subfamily KQT member 5
    ELISA Kit for Human Potassium voltage-gated channel subfamily KQT member 5
    CLIA Kit for Human Potassium voltage-gated channel subfamily KQT member 5
    CLIA Kit for Human Potassium voltage-gated channel subfamily KQT member 5
    Polyclonal Antibody for Human Potassium voltage-gated channel subfamily KQT member 5
    Polyclonal Antibody for Human Potassium voltage-gated channel subfamily KQT member 5
    Monoclonal Antibody for Human Potassium voltage-gated channel subfamily KQT member 5
    Monoclonal Antibody for Human Potassium voltage-gated channel subfamily KQT member 5
    Protein for Human Potassium voltage-gated channel subfamily KQT member 5
    Protein for Human Potassium voltage-gated channel subfamily KQT member 5

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    Precision
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    Recovery
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    References
    1. 1.
      "Molecular cloning and functional expression of KCNQ5, a potassium channel subunit that may contribute to neuronal M-current diversity."
      Lerche C. , Scherer C.R. , Seebohm G. , Derst C. , Wei A.D. , Busch A.E. , Steinmeyer K.
      J. Biol. Chem.275:22395-22400(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Brain.
    2. 2.
      "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J. , Palmer S.A. , Sims S.K. , Edwards C.A. , Ashurst J.L. , Wilming L. , Jones M.C. , Horton R. , Hunt S.E. , Scott C.E. , Gilbert J.G.R. , Clamp M.E. , Bethel G. , Milne S. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Andrews T.D. , more...
      Nature425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    3. 3.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 4)
      tissue: Placenta.
    4. 4.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 19-822 (ISOFORM 5)
      tissue: Brain.
    5. 5.
      "KCNQ5, a novel potassium channel broadly expressed in brain, mediates M-type currents."
      Schroeder B.C. , Hechenberger M. , Weinreich F. , Kubisch C. , Jentsch T.J.
      J. Biol. Chem.275:24089-24095(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 36-932 (ISOFORMS 1; 2 AND 3)
      tissue: Brain.
    6. 6.
      "The new voltage gated potassium channel KCNQ5 and early infantile convulsions."
      Kananura C. , Biervert B. , Hechenberger M. , Engels H. , Steinlein O.K.
      Submitted (2000-02) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 36-932
    7. 7.
      "A new gene of the voltage-gated potassium channel KCNQ family, KCNQ5, is a candidate gene for retinal disorders."
      Kniazeva M. , Han M.
      Submitted (2000-05) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 72-932 (ISOFORM 1)
      tissue: Brain.
      tissue: Retina.
    8. 8.
      "Characterization of KCNQ5/Q3 potassium channels expressed in mammalian cells."
      Wickenden A.D. , Zou A. , Wagoner P.K. , Jegla T.
      Br. J. Pharmacol.132:381-384(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION;ACTIVATION BY RETICABINE
    9. 9.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS [LARGE SCALE ANALYSIS] GLY-191 AND CYS-244
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