Protein name:
Potassium voltage-gated channel subfamily KQT member 5 ;
Alternative:
Potassium channel subunit alpha KvLQT5 ;KQT-like 5 ;Voltage-gated potassium channel subunit Kv7.5 ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Heteromultimer with KCNQ3.
Function:
Probably important in the regulation of neuronal excitability. Associates with KCNQ3 to form a potassium channel which contributes to M-type current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons. May contribute, with other potassium channels, to the molecular diversity of an heterogeneous population of M-channels, varying in kinetic and pharmacological properties, which underlie this physiologically important current. Insensitive to tetraethylammonium, but inhibited by barium, linopirdine and XE991. Activated by niflumic acid and the anticonvulsant retigabine. Muscarine suppresses KCNQ5 current in Xenopus oocytes in which cloned KCNQ5 channels were coexpressed with M(1) muscarinic receptors.
Subcellular Location:
Membrane
Multi-pass membrane protein
Protein Attributes:
50:
MPRHHAGGEE | GGAAGLWVKS | GAAAAAAGGG | RLGSGMKDVE | SGRGRVLLNS |
100:
AAARGDGLLL | LGTRAATLGG | GGGGLRESRR | GKQGARMSLL | GKPLSYTSSQ |
150:
SCRRNVKYRR | VQNYLYNVLE | RPRGWAFIYH | AFVFLLVFGC | LILSVFSTIP |
200:
EHTKLASSCL | LILEFVMIVV | FGLEFIIRIW | SAGCCCRYRG | WQGRLRFARK |
250:
PFCVIDTIVL | IASIAVVSAK | TQGNIFATSA | LRSLRFLQIL | RMVRMDRRGG |
300:
TWKLLGSVVY | AHSKELITAW | YIGFLVLIFS | SFLVYLVEKD | ANKEFSTYAD |
350:
ALWWGTITLT | TIGYGDKTPL | TWLGRLLSAG | FALLGISFFA | LPAGILGSGF |
400:
ALKVQEQHRQ | KHFEKRRNPA | ANLIQCVWRS | YAADEKSVSI | ATWKPHLKAL |
450:
HTCSPTKKEQ | GEASSSQKLS | FKERVRMASP | RGQSIKSRQA | SVGDRRSPST |
500:
DITAEGSPTK | VQKSWSFNDR | TRFRPSLRLK | SSQPKPVIDA | DTALGTDDVY |
550:
DEKGCQCDVS | VEDLTPPLKT | VIRAIRIMKF | HVAKRKFKET | LRPYDVKDVI |
600:
EQYSAGHLDM | LCRIKSLQTR | VDQILGKGQI | TSDKKSREKI | TAEHETTDDL |
650:
SMLGRVVKVE | KQVQSIESKL | DCLLDIYQQV | LRKGSASALA | LASFQIPPFE |
700:
CEQTSDYQSP | VDSKDLSGSA | QNSGCLSRST | SANISRGLQF | ILTPNEFSAQ |
750:
TFYALSPTMH | SQATQVPISQ | SDGSAVAATN | TIANQINTAP | KPAAPTTLQI |
800:
PPPLPAIKHL | PRPETLHPNP | AGLQESISDV | TTCLVASKEN | VQVAQSNLTK |
850:
DRSMRKSFDM | GGETLLSVCP | MVPKDLGKSL | SVQNLIRSTE | ELNIQLSGSE |
900:
SSGSRGSQDF | YPKWRESKLF | ITDEEVGPEE | TETDTFDAAP | QPAREAAFAS |
932:
DSLRTGRSRS | SQSICKAGES | TDALSLPHVK | LK
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
ELISA Kit for Human Potassium voltage-gated channel subfamily KQT member 5
ELISA Kit for Human Potassium voltage-gated channel subfamily KQT member 5
CLIA Kit for Human Potassium voltage-gated channel subfamily KQT member 5
CLIA Kit for Human Potassium voltage-gated channel subfamily KQT member 5
Polyclonal Antibody for Human Potassium voltage-gated channel subfamily KQT member 5
Polyclonal Antibody for Human Potassium voltage-gated channel subfamily KQT member 5
Monoclonal Antibody for Human Potassium voltage-gated channel subfamily KQT member 5
Monoclonal Antibody for Human Potassium voltage-gated channel subfamily KQT member 5
Protein for Human Potassium voltage-gated channel subfamily KQT member 5
Protein for Human Potassium voltage-gated channel subfamily KQT member 5
R&D Technical Data
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Precision
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Recovery
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Linearity
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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Cited for : VARIANTS [LARGE SCALE ANALYSIS] GLY-191 AND CYS-244