Gene name:
KCP (CRIM2;KCP1) ;
Protein name:
Kielin/chordin-like protein ;
Alternative:
Cysteine-rich motor neuron 2 protein (CRIM-2) ;Cysteine-rich BMP regulator 2 ;Kielin/chordin-like protein 1 (KCP-1) ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts with BMP7 and, by doing so, enhances binding to the type I receptors that contains cytoplasmic serine/threonine protein kinase domains. Also able to interact with activin-A and TGFB1.
Function:
Enhances bone morphogenetic protein (BMP) signaling in a paracrine manner. In contrast, it inhibits both the activin-A and TGFB1-mediated signaling pathways.
Subcellular Location:
Secreted
Protein Attributes:
50:
MAGVGAAALS | LLLHLGALAL | AAGAEGGAVP | REPPGQQTTA | HSSVLAGNSQ |
100:
EQWHPLREWL | GRLEAAVMEL | REQNKDLQTR | VRQLESCECH | PASPQCWGLG |
150:
RAWPEGARWE | PDACTACVCQ | DGAAHCGPQA | HLPHCRGCSQ | NGQTYGNGET |
200:
FSPDACTTCR | CLTGAVQCQG | PSCSELNCLE | SCTPPGECCP | ICCTEGGSHW |
250:
EHGQEWTTPG | DPCRICRCLE | GHIQCRQREC | ASLCPYPARP | LPGTCCPVCD |
300:
GCFLNGREHR | SGEPVGSGDP | CSHCRCANGS | VQCEPLPCPP | VPCRHPGKIP |
350:
GQCCPVCDGC | EYQGHQYQSQ | ETFRLQERGL | CVRCSCQAGE | VSCEEQECPV |
400:
TPCALPASGR | QLCPACELDG | EEFAEGVQWE | PDGRPCTACV | CQDGVPKCGA |
450:
VLCPPAPCQH | PTQPPGACCP | SCDSCTYHSQ | VYANGQNFTD | ADSPCHACHC |
500:
QDGTVTCSLV | DCPPTTCARP | QSGPGQCCPR | CPDCILEEEV | FVDGESFSHP |
550:
RDPCQECRCQ | EGHAHCQPRP | CPRAPCAHPL | PGTCCPNDCS | GCAFGGKEYP |
600:
SGADFPHPSD | PCRLCRCLSG | NVQCLARRCV | PLPCPEPVLL | PGECCPQCPA |
650:
PAGCPRPGAA | HARHQEYFSP | PGDPCRRCLC | LDGSVSCQRL | PCPPAPCAHP |
700:
RQGPCCPSCD | GCLYQGKEFA | SGERFPSPTA | ACHLCLCWEG | SVSCEPKACA |
750:
PALCPFPARG | DCCPDCDGCE | YLGESYLSNQ | EFPDPREPCN | LCTCLGGFVT |
800:
CGRRPCEPPG | CSHPLIPSGH | CCPTCQGCRY | HGVTTASGET | LPDPLDPTCS |
850:
LCTCQEGSMR | CQKKPCPPAL | CPHPSPGPCF | CPVCHSCLSQ | GREHQDGEEF |
900:
EGPAGSCEWC | RCQAGQVSCV | RLQCPPLPCK | LQVTERGSCC | PRCRGCLAHG |
950:
EEHPEGSRWV | PPDSACSSCV | CHEGVVTCAR | IQCISSCAQP | RQGPHDCCPQ |
1000:
CSDCEHEGRK | YEPGESFQPG | ADPCEVCICE | PQPEGPPSLR | CHRRQCPSLV |
1050:
GCPPSQLLPP | GPQHCCPTCA | EALSNCSEGL | LGSELAPPDP | CYTCQCQDLT |
1100:
WLCIHQACPE | LSCPLSERHT | PPGSCCPVCR | APTQSCVHQG | REVASGERWT |
1150:
VDTCTSCSCM | AGTVRCQSQR | CSPLSCGPDK | APALSPGSCC | PRCLPRPASC |
1200:
MAFGDPHYRT | FDGRLLHFQG | SCSYVLAKDC | HSGDFSVHVT | NDDRGRSGVA |
1250:
WTQEVAVLLG | DMAVRLLQDG | AVTVDGHPVA | LPFLQEPLLY | VELRGHTVIL |
1300:
HAQPGLQVLW | DGQSQVEVSV | PGSYQGRTCG | LCGNFNGFAQ | DDLQGPEGLL |
1350:
LPSEAAFGNS | WQVSEGLWPG | RPCSAGREVD | PCRAAGYRAR | REANARCGVL |
1400:
KSSPFSRCHA | VVPPEPFFAA | CVYDLCACGP | GSSADACLCD | ALEAYASHCR |
1450:
QAGVTPTWRG | PTLCVVGCPL | ERGFVFDECG | PPCPRTCFNQ | HIPLGELAAH |
1500:
CVRPCVPGCQ | CPAGLVEHEA | HCIPPEACPQ | VLLTGDQPLG | ARPSPSREPQ |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
ELISA Kit for Human Kielin/chordin-like protein
ELISA Kit for Human Kielin/chordin-like protein
CLIA Kit for Human Kielin/chordin-like protein
CLIA Kit for Human Kielin/chordin-like protein
Polyclonal Antibody for Human Kielin/chordin-like protein
Polyclonal Antibody for Human Kielin/chordin-like protein
Monoclonal Antibody for Human Kielin/chordin-like protein
Monoclonal Antibody for Human Kielin/chordin-like protein
Protein for Human Kielin/chordin-like protein
Protein for Human Kielin/chordin-like protein
R&D Technical Data
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Precision
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Recovery
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Linearity
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
tissue :
Thalamus .
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Submitted (2005-07) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]