MVK ELISA Kit for Human(Homo sapiens) | EIAab.comMVK ELISA Kit for Human(Homo sapiens)

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Index > Protein center > MVK(Gene name) > Human

MVK (Gene name),

Mevalonate kinase (Protein name ), KIME_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

MVK;

Protein name:

Mevalonate kinase(MK);

Alternative:

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Homodimer.

Function:

May be a regulatory site in cholesterol biosynthetic pathway.

Subcellular Location:

Cytoplasm Peroxisome

Protein Attributes:

Sequence length:

396

Sequence:

50:

100:

150:

200:

250:

300:

350:

396:

PEVEATKQAL | TSCGFDCLET | SIGAPGVSIH | SATSLDSRVQ | QALDGL

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

Pfam:

PF08544

MIM:

251170

SMR:

Q03426

String:

Q03426

KEGG:

hsa:4598

STRING:

9606.ENSP00000228510

UniGene:

Hs.130607

Uniprot:

Q03426

FOR

ELISA Kit for Human MK

CLIA Kit for Human MK

Polyclonal Antibody for Human MK

Monoclonal Antibody for Human MK

Protein for Human MK

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Molecular cloning of human mevalonate kinase and identification of a missense mutation in the genetic disease mevalonic aciduria."
Schafer B.L. , Bishop R.W. , Kratunis V.J. , Kalinowski S.S. , Mosley S.T. , Gibson K.M. , Tanaka R.D.
J. Biol. Chem.267:13229-13238(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANT MEVA THR-301
2.

"Insertional activation of mevalonate kinase by hepatitis B virus DNA in a human hepatoma cell line."
Graef E. , Caselmann W.H. , Wells J. , Koshy R.
Oncogene9:81-87(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Hepatoma.
3.

"Organization of the mevalonate kinase (MVK) gene and identification of novel mutations causing mevalonic aciduria and hyperimmunoglobulinaemia D and periodic fever syndrome."
Houten S.M. , Koster J. , Romeijn G.-J. , Frenkel J. , Di Rocco M. , Caruso U. , Landrieu P. , Kelley R.I. , Kuis W. , Poll-The B.T. , Gibson K.M. , Wanders R.J.A. , Waterham H.R.
Eur. J. Hum. Genet.9:253-259(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS HIDS PRO-20; PRO-39; LEU-135; THR-148; THR-268 AND ILE-377;VARIANTS MEVA PRO-20; PHE-264; THR-268; MET-310 AND THR-334
4.

Houten S.M. , Koster J. , Romeijn G.-J. , Frenkel J. , Di Rocco M. , Caruso U. , Landrieu P. , Kelley R.I. , Kuis W. , Poll-The B.T. , Gibson K.M. , Wanders R.J.A. , Waterham H.R.
Eur. J. Hum. Genet.9:651-651(2001)

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM
5.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Skin.
6.

"Mevalonate kinase is a cytosolic enzyme in humans."
Hogenboom S. , Tuyp J.J. , Espeel M. , Koster J. , Wanders R.J. , Waterham H.R.
J. Cell Sci.117:631-639(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
7.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
8.

"Identification of a mutation cluster in mevalonate kinase deficiency, including a new mutation in a patient of Mennonite ancestry."
Hinson D.D. , Ross R.M. , Krisans S. , Shaw J.L. , Kozich V. , Rolland M.-O. , Divry P. , Mancini J. , Hoffmann G.F. , Gibson K.M.
Am. J. Hum. Genet.65:327-335(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS MEVA ILE-243; PHE-264; PRO-265 AND THR-268
9.

"Identification and characterization of three novel missense mutations in mevalonate kinase cDNA causing mevalonic aciduria, a disorder of isoprene biosynthesis."
Houten S.M. , Romeijn G.J. , Koster J. , Gray R.G.F. , Darbyshire P. , Smit G.P.A. , de Klerk J.B.C. , Duran R. , Gibson K.M. , Wanders R.J.A. , Waterham H.R.
Hum. Mol. Genet.8:1523-1528(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS MEVA MET-310 AND THR-334
10.

"Mutations in MVK, encoding mevalonate kinase, cause hyperimmunoglobulinaemia D and periodic fever syndrome."
Houten S.M. , Kuis W. , Duran M. , de Koning T.J. , van Royen-Kerkhof A. , Romeijn G.J. , Frenkel J. , Dorland L. , de Barse M.M.J. , Huijbers W.A.R. , Rijkers G.T. , Waterham H.R. , Wanders R.J.A. , Poll-The B.T.
Nat. Genet.22:175-177(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS HIDS PRO-20; THR-268 AND ILE-377
11.

"Mutations in the gene encoding mevalonate kinase cause hyper-IgD and periodic fever syndrome."
Drenth J.P.H. , Cuisset L. , Grateau G. , Vasseur C. , van der Velde-Visser S.D. , de Jong J.G.N. , Beckmann J.S. , van der Meer J.W.M. , Delpech M.
Nat. Genet.22:178-181(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS HIDS LEU-167; THR-268 AND ILE-377
12.

"Molecular analysis of MVK mutations and enzymatic activity in hyper-IgD and periodic fever syndrome."
Cuisset L. , Drenth J.P.H. , Simon A. , Vincent M.-F. , van der Velde-Visser S.D. , van der Meer J.W.M. , Grateau G. , Delpech M.
Eur. J. Hum. Genet.9:260-266(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS HIDS ASN-20; PRO-20; PRO-39; LEU-150; LEU-167; ARG-202; GLN-215; THR-268; SER-309; ARG-326 AND ILE-377;VARIANT MEVA THR-334;VARIANT ASN-52
13.

"MVK mutations and associated clinical features in Italian patients affected with autoinflammatory disorders and recurrent fever."
D'Osualdo A. , Picco P. , Caroli F. , Gattorno M. , Giacchino R. , Fortini P. , Corona F. , Tommasini A. , Salvi G. , Specchia F. , Obici L. , Meini A. , Ricci A. , Seri M. , Ravazzolo R. , Martini A. , Ceccherini I.
Eur. J. Hum. Genet.13:314-320(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS HIDS GLN-20; ILE-132; THR-148; ARG-171; GLU-211; GLN-215; ILE-250; ARG-265; THR-268; MET-310; VAL-376 AND ILE-377;VARIANTS ASN-52 AND MET-356

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