Protein name:
Metastasis-suppressor KiSS-1 ;
Alternative:
Kisspeptin-1 ;
Organism:
Mouse (Mus musculus).
General Annotation
Function:
Metastasis suppressor protein. May regulate events downstream of cell-matrix adhesion, perhaps involving cytoskeletal reorganization. Generates a C-terminally amidated peptide, metastin which functions as the endogenous ligand of the G-protein coupled receptor GPR54. Activation of the receptor inhibits cell proliferation and cell migration, key characteristics of tumor metastasis. The receptor is also essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/GPR54 system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood. Intracerebroventricular administration induces an increase in serum LH and FSH levels in prepubertal male and female as well as in adult animals.
Subcellular Location:
Secreted
Protein Attributes:
50:
MISMASWQLL | LLLCVATYGE | PLAKVAPLVK | PGSTGQQSGP | QELVNAWEKE |
100:
SRYAESKPGS | AGLRARRSSP | CPPVEGPAGR | QRPLCASRSR | LIPAPRGAVL |
130:
VQREKDLSTY | NWNSFGLRYG | RRQAARAARG |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Rat
Human
Mouse
ELISA Kit for Mouse Metastasis-suppressor KiSS-1
ELISA Kit for Mouse Metastasis-suppressor KiSS-1
ELISA Kit for Mouse Metastasis-suppressor KiSS-1
CLIA Kit for Mouse Metastasis-suppressor KiSS-1
CLIA Kit for Mouse Metastasis-suppressor KiSS-1
CLIA Kit for Mouse Metastasis-suppressor KiSS-1
Polyclonal Antibody for Mouse Metastasis-suppressor KiSS-1
Polyclonal Antibody for Mouse Metastasis-suppressor KiSS-1
Polyclonal Antibody for Mouse Metastasis-suppressor KiSS-1
Monoclonal Antibody for Mouse Metastasis-suppressor KiSS-1
Monoclonal Antibody for Mouse Metastasis-suppressor KiSS-1
Monoclonal Antibody for Mouse Metastasis-suppressor KiSS-1
Protein for Mouse Metastasis-suppressor KiSS-1
Protein for Mouse Metastasis-suppressor KiSS-1
Protein for Mouse Metastasis-suppressor KiSS-1
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);CHARACTERIZATION;TISSUE SPECIFICITY
strain :
129S6/SvEvTac .
tissue :
Brain .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2)
tissue :
Embryo .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
strain :
ICR .
tissue :
Brain .
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
strain :
C57BL/6J .
tissue :
Placenta .
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue :
Brain .
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : TISSUE SPECIFICITY;ROLE IN THE REGULATION OF GONADOTROPIN SECRETION
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INVOLVEMENT IN REGULATION OF GONADOTROPIN SECRETION
8.
"Advanced vaginal opening and precocious activation of the reproductive axis by KiSS-1 peptide, the endogenous ligand of GPR54."
Navarro V.M.
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Fernandez-Fernandez R.
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Castellano J.M.
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Roa J.
,
Mayen A.
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Barreiro M.L.
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J. Physiol. (Lond.)561:379-386(2004)
[
PubMed ]
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Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION
9.
"Characterization of the potent luteinizing hormone-releasing activity of KiSS-1 peptide, the natural ligand of GPR54."
Navarro V.M.
,
Castellano J.M.
,
Fernandez-Fernandez R.
,
Tovar S.
,
Roa J.
,
Mayen A.
,
Nogueiras R.
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Vazquez M.J.
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Barreiro M.L.
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Magni P.
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Aguilar E.
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Dieguez C.
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Pinilla L.
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Tena-Sempere M.
Endocrinology146:156-163(2005)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ROLE IN LUTEINIZING HORMONE SECRETION
10.
"Kisspeptin directly stimulates gonadotropin-releasing hormone release via G protein-coupled receptor 54."
Messager S.
,
Chatzidaki E.E.
,
Ma D.
,
Hendrick A.G.
,
Zahn D.
,
Dixon J.
,
Thresher R.R.
,
Malinge I.
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Lomet D.
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Carlton M.B.
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Colledge W.H.
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Caraty A.
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Aparicio S.A.J.R.
Proc. Natl. Acad. Sci. U.S.A.102:1761-1766(2005)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : DIRECT STIMULATION OF GONADOTROPIN-RELEASING HORMONE RELEASE
11.
"Effects of KiSS-1 peptide, the natural ligand of GPR54, on follicle-stimulating hormone secretion in the rat."
Navarro V.M.
,
Castellano J.M.
,
Fernandez-Fernandez R.
,
Tovar S.
,
Roa J.
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Mayen A.
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Barreiro M.L.
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Casanueva F.F.
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Aguilar E.
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Dieguez C.
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Pinilla L.
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Tena-Sempere M.
Endocrinology146:1689-1697(2005)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ROLE IN FOLLICLE-STIMULATING HORMONE SECRETION
12.
"Hypogonadotropic hypogonadism in mice lacking a functional Kiss1 gene."
d'Anglemont de Tassigny X.
,
Fagg L.A.
,
Dixon J.P.
,
Day K.
,
Leitch H.G.
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Hendrick A.G.
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Zahn D.
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Franceschini I.
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Caraty A.
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Colledge W.H.
Proc. Natl. Acad. Sci. U.S.A.104:10714-10719(2007)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : DISRUPTION PHENOTYPE