Gene name:
KLK8 (UNQ283/PRO322;NRPN;PRSS19;TADG14) ;
Protein name:
Kallikrein-8 (hK8) ;
Alternative:
Ovasin ;Neuropsin (NP) ;Serine protease TADG-14 ;Serine protease 19 ;Tumor-associated differentially expressed gene 14 protein ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts with SPINK9.
Function:
Serine protease which is capable of degrading a number of proteins such as casein, fibrinogen, kininogen, fibronectin and collagen type IV. Also cleaves L1CAM in response to increased neural activity. Induces neurite outgrowth and fasciculation of cultured hippocampal neurons. Plays a role in the formation and maturation of orphan and small synaptic boutons in the Schaffer-collateral pathway, regulates Schaffer-collateral long-term potentiation in the hippocampus and is required for memory acquisition and synaptic plasticity. Involved in skin desquamation and keratinocyte proliferation. Plays a role in the secondary phase of pathogenesis following spinal cord injury.
Subcellular Location:
Secreted
Cytoplasm
Shows a cytoplasmic distribution in the keratinocytes.
Protein Attributes:
50:
MGRPRPRAAK | TWMFLLLLGG | AWAGHSRAQE | DKVLGGHECQ | PHSQPWQAAL |
100:
FQGQQLLCGG | VLVGGNWVLT | AAHCKKPKYT | VRLGDHSLQN | KDGPEQEIPV |
150:
VQSIPHPCYN | SSDVEDHNHD | LMLLQLRDQA | SLGSKVKPIS | LADHCTQPGQ |
200:
KCTVSGWGTV | TSPRENFPDT | LNCAEVKIFP | QKKCEDAYPG | QITDGMVCAG |
250:
SSKGADTCQG | DSGGPLVCDG | ALQGITSWGS | DPCGRSDKPG | VYTNICRYLD |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Rat
Polyclonal Antibody for Human hK8
Polyclonal Antibody for Human hK8
Polyclonal Antibody for Human hK8
Monoclonal Antibody for Human hK8
Monoclonal Antibody for Human hK8
Monoclonal Antibody for Human hK8
R&D Technical Data
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Precision
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Recovery
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Linearity
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Citations
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH SPINK9