Klk8 ELISA Kit for Mouse(Mus musculus) | EIAab.comKlk8 ELISA Kit for Mouse(Mus musculus)

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Klk8 (Gene name),

Kallikrein-8 (Protein name ), KLK8_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Klk8(Nrpn;Prss19);

Protein name:

Kallikrein-8(mK8);

Alternative:

Serine protease 19;Neuropsin(NP);

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Interacts with SPINK9.

Function:

Serine protease which is capable of degrading a number of proteins such as casein, fibrinogen, kininogen, fibronectin and collagen type IV. Also cleaves L1CAM in response to increased neural activity. Induces neurite outgrowth and fasciculation of cultured hippocampal neurons. Plays a role in the formation and maturation of orphan and small synaptic boutons in the Schaffer-collateral pathway, regulates Schaffer-collateral long-term potentiation in the hippocampus and is required for memory acquisition and synaptic plasticity. Involved in skin desquamation and keratinocyte proliferation. Plays a role in the secondary phase of pathogenesis following spinal cord injury.

Subcellular Location:

Secreted Cytoplasm Shows a cytoplasmic distribution in the keratinocytes.

Protein Attributes:

Sequence length:

260

Sequence:

50:

100:

150:

200:

250:

260:

WIKKTMDNRD |

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

STRING:

10090.ENSMUSP00000082588

UniGene:

Mm.458023

String:

Q61955

Pfam:

PF00089

SMR:

Q61955

KEGG:

mmu:259277

Uniprot:

Q61955

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ELISA Kit for Mouse mK8

Cat.:

E0690h

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96T

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ELISA Kit for Mouse mK8

Cat.:

E0690m

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96T

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ELISA Kit for Mouse mK8

Cat.:

E0690r

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96T

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CLIA Kit for Mouse mK8

Cat.:

U0690r

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96T

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CLIA Kit for Mouse mK8

Cat.:

U0690m

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96T

CLIA Kit for Mouse mK8

Cat.:

U0690h

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96T

Polyclonal Antibody for Mouse mK8

Cat.:

P0690Rb-h

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40ug/0.2ml

Polyclonal Antibody for Mouse mK8

Cat.:

P0690Rb-r

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40ug/0.2ml

Polyclonal Antibody for Mouse mK8

Cat.:

P0690Rb-m

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40ug/0.2ml

Monoclonal Antibody for Mouse mK8

Protein for Mouse mK8

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Expression and activity-dependent changes of a novel limbic-serine protease gene in the hippocampus."
Chen Z.-L. , Yoshida S. , Kato K. , Momota Y. , Suzuki J. , Tanaka T. , Ito J. , Nishino H. , Aimoto S. , Kiyama H. , Shiosaka S.
J. Neurosci.15:5088-5097(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];TISSUE SPECIFICITY
strain: BALB/c.
tissue: Hippocampus.
2.

"Assignment of the neuropsin gene (Prss19) to mouse chromosome band 7B4 by in situ hybridization."
Yoshida S. , Hirata A. , Inoue N. , Shiosaka S.
Cytogenet. Cell Genet.88:97-98(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
3.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain: Czech II.
tissue: Mammary gland.
4.

"Characterization of recombinant and brain neuropsin, a plasticity-related serine protease."
Shimizu C. , Yoshida S. , Shibata M. , Kato K. , Momota Y. , Matsumoto K. , Shiosaka T. , Midorikawa R. , Kamachi T. , Kawabe A. , Shiosaka S.
J. Biol. Chem.273:11189-11196(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF N-TERMINUS;FUNCTION;ENZYME REGULATION;BIOPHYSICOCHEMICAL PROPERTIES;SUBCELLULAR LOCATION;MASS SPECTROMETRY
strain: BALB/c.
tissue: Brain.
5.

"Estrogen-independent expression of neuropsin, a serine protease in the vagina of mice exposed neonatally to diethylstilbestrol."
Katsu Y. , Takasu E. , Iguchi T.
Mol. Cell. Endocrinol.195:99-107(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 85-260;TISSUE SPECIFICITY
strain: C57BL/6.
6.

"Ontogeny of neuropsin mRNA expression in the mouse brain."
Suzuki J. , Yoshida S. , Chen Z.-L. , Momota Y. , Kato K. , Hirata A. , Shiosaka S.
Neurosci. Res.23:345-351(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY;DEVELOPMENTAL STAGE
7.

"Kindling induces neuropsin mRNA in the mouse brain."
Okabe A. , Momota Y. , Yoshida S. , Hirata A. , Ito J. , Nishino H. , Shiosaka S.
Brain Res.728:116-120(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION
8.

"Effects of oxidative stress on the expression of limbic-specific protease neuropsin and avoidance learning in mice."
Akita H. , Matsuyama T. , Iso H. , Sugita M. , Yoshida S.
Brain Res.769:86-96(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION
9.

"Blockade of neuropsin, a serine protease, ameliorates kindling epilepsy."
Momota Y. , Yoshida S. , Ito J. , Shibata M. , Kato K. , Sakurai K. , Matsumoto K. , Shiosaka S.
Eur. J. Neurosci.10:760-764(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY;INDUCTION
10.

"Expression of neuropsin in the keratinizing epithelial tissue -immunohistochemical analysis of wild-type and nude mice."
Inoue N. , Kuwae K. , Ishida-Yamamoto A. , Iizuka H. , Shibata M. , Yoshida S. , Kato K. , Shiosaka S.
J. Invest. Dermatol.110:923-931(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
11.

"Effect of 12-O-tetradecanoyl-phorbol ester and incisional wounding on neuropsin mRNA and its protein expression in murine skin."
Kitayoshi H. , Inoue N. , Kuwae K. , Chen Z.-L. , Sato H. , Ohta T. , Hosokawa K. , Itami S. , Yoshikawa K. , Yoshida S. , Shiosaka S.
Arch. Dermatol. Res.291:333-338(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION
12.

"Injury induces neuropsin mRNA in the central nervous system."
Tomizawa K. , He X.-P. , Yamanaka H. , Shiosaka S. , Yoshida S.
Brain Res.824:308-311(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION
13.

"Neuropsin regulates an early phase of Schaffer-collateral long-term potentiation in the murine hippocampus."
Komai S. , Matsuyama T. , Matsumoto K. , Kato K. , Kobayashi M. , Imamura K. , Yoshida S. , Ugawa S. , Shiosaka S.
Eur. J. Neurosci.12:1479-1486(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
14.

"Loss of hippocampal serine protease BSP1/neuropsin predisposes to global seizure activity."
Davies B. , Kearns I.R. , Ure J. , Davies C.H. , Lathe R.
J. Neurosci.21:6993-7000(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE
15.

"Abnormalities of synapses and neurons in the hippocampus of neuropsin-deficient mice."
Hirata A. , Yoshida S. , Inoue N. , Matsumoto-Miyai K. , Ninomiya A. , Taniguchi M. , Matsuyama T. , Kato K. , Iizasa H. , Kataoka Y. , Yoshida N. , Shiosaka S.
Mol. Cell. Neurosci.17:600-610(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE
16.

"Expression of neuropsin in oligodendrocytes after injury to the CNS."
He X.-P. , Shiosaka S. , Yoshida S.
Neurosci. Res.39:455-462(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION
17.

"Extracellular serine protease neuropsin (KLK8) modulates neurite outgrowth and fasciculation of mouse hippocampal neurons in culture."
Oka T. , Akisada M. , Okabe A. , Sakurai K. , Shiosaka S. , Kato K.
Neurosci. Lett.321:141-144(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
18.

"Prolonged recovery of ultraviolet B-irradiated skin in neuropsin (KLK8)-deficient mice."
Kirihara T. , Matsumoto-Miyai K. , Nakamura Y. , Sadayama T. , Yoshida S. , Shiosaka S.
Br. J. Dermatol.149:700-706(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION;DISRUPTION PHENOTYPE
19.

"NMDA-dependent proteolysis of presynaptic adhesion molecule L1 in the hippocampus by neuropsin."
Matsumoto-Miyai K. , Ninomiya A. , Yamasaki H. , Tamura H. , Nakamura Y. , Shiosaka S.
J. Neurosci.23:7727-7736(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
20.

"Role of neuropsin in formation and maturation of Schaffer-collateral L1cam-immunoreactive synaptic boutons."
Nakamura Y. , Tamura H. , Horinouchi K. , Shiosaka S.
J. Cell Sci.119:1341-1349(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DISRUPTION PHENOTYPE
21.

"Neuropsin is essential for early processes of memory acquisition and Schaffer collateral long-term potentiation in adult mouse hippocampus in vivo."
Tamura H. , Ishikawa Y. , Hino N. , Maeda M. , Yoshida S. , Kaku S. , Shiosaka S.
J. Physiol. (Lond.)570:541-551(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DISRUPTION PHENOTYPE
22.

"SerpinB6 is an inhibitor of kallikrein-8 in keratinocytes."
Scott F.L. , Sun J. , Whisstock J.C. , Kato K. , Bird P.I.
J. Biochem.142:435-442(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;TISSUE SPECIFICITY
23.

"Kallikrein 8 is involved in skin desquamation in cooperation with other kallikreins."
Kishibe M. , Bando Y. , Terayama R. , Namikawa K. , Takahashi H. , Hashimoto Y. , Ishida-Yamamoto A. , Jiang Y.-P. , Mitrovic B. , Perez D. , Iizuka H. , Yoshida S.
J. Biol. Chem.282:5834-5841(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DISRUPTION PHENOTYPE
24.

"Neuropsin promotes oligodendrocyte death, demyelination and axonal degeneration after spinal cord injury."
Terayama R. , Bando Y. , Murakami K. , Kato K. , Kishibe M. , Yoshida S.
Neuroscience148:175-187(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY;INDUCTION;DISRUPTION PHENOTYPE
25.

"Crystal structure of neuropsin, a hippocampal protease involved in kindling epileptogenesis."
Kishi T. , Kato M. , Shimizu T. , Kato K. , Matsumoto K. , Yoshida S. , Shiosaka S. , Hakoshima T.
J. Biol. Chem.274:4220-4224(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 33-257
tissue: Hippocampus.

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