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Index > Protein center > PHKA1(Gene name) > Human
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  • PHKA1 (Gene name),
  • Phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform (Protein name ),  KPB1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    PHKA1(PHKA);
    Protein name:
    Phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform(Phosphorylase kinase alpha M subunit);
    Alternative:

    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Hexadecamer of 4 heterotetramers, each composed of alpha, beta, gamma, and delta subunits. Alpha (PHKA1 or PHKA2) and beta (PHKB) are regulatory subunits, gamma (PHKG1 or PHKG2) is the catalytic subunit, and delta is calmodulin.
    Function:
    Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may bind calmodulin.
    Subcellular Location:
    Cell membrane Lipid-anchor Cytoplasmic side
    Protein Attributes:
    Sequence length:
    1223
    Sequence:
    50:
    MRSRSNSGVR | LDGYARLVQQ | TILCHQNPVT | GLLPASYDQK | DAWVRDNVYS | 
    100:
    ILAVWGLGLA | YRKNADRDED | KAKAYELEQS | VVKLMRGLLH | CMIRQVDKVE | 
    150:
    SFKYSQSTKD | SLHAKYNTKT | CATVVGDDQW | GHLQLDATSV | YLLFLAQMTA | 
    200:
    SGLHIIHSLD | EVNFIQNLVF | YIEAAYKTAD | FGIWERGDKT | NQGISELNAS | 
    250:
    SVGMAKAALE | ALDELDLFGV | KGGPQSVIHV | LADEVQHCQS | ILNSLLPRAS | 
    300:
    TSKEVDASLL | SVVSFPAFAV | EDSQLVELTK | QEIITKLQGR | YGCCRFLRDG | 
    350:
    YKTPKEDPNR | LYYEPAELKL | FENIECEWPL | FWTYFILDGV | FSGNAEQVQE | 
    400:
    YKEALEAVLI | KGKNGVPLLP | ELYSVPPDRV | DEEYQNPHTV | DRVPMGKLPH | 
    450:
    MWGQSLYILG | SLMAEGFLAP | GEIDPLNRRF | STVPKPDVVV | QVSILAETEE | 
    500:
    IKTILKDKGI | YVETIAEVYP | IRVQPARILS | HIYSSLGCNN | RMKLSGRPYR | 
    550:
    HMGVLGTSKL | YDIRKTIFTF | TPQFIDQQQF | YLALDNKMIV | EMLRTDLSYL | 
    600:
    CSRWRMTGQP | TITFPISHSM | LDEDGTSLNS | SILAALRKMQ | DGYFGGARVQ | 
    650:
    TGKLSEFLTT | SCCTHLSFMD | PGPEGKLYSE | DYDDNYDYLE | SGNWMNDYDS | 
    700:
    TSHARCGDEV | ARYLDHLLAH | TAPHPKLAPT | SQKGGLDRFQ | AAVQTTCDLM | 
    750:
    SLVTKAKELH | VQNVHMYLPT | KLFQASRPSF | NLLDSPHPRQ | ENQVPSVRVE | 
    800:
    IHLPRDQSGE | VDFKALVLQL | KETSSLQEQA | DILYMLYTMK | GPDWNTELYN | 
    850:
    ERSATVRELL | TELYGKVGEI | RHWGLIRYIS | GILRKKVEAL | DEACTDLLSH | 
    900:
    QKHLTVGLPP | EPREKTISAP | LPYEALTQLI | DEASEGDMSI | SILTQEIMVY | 
    950:
    LAMYMRTQPG | LFAEMFRLRI | GLIIQVMATE | LAHSLRCSAE | EATEGLMNLS | 
    1000:
    PSAMKNLLHH | ILSGKEFGVE | RSVRPTDSNV | SPAISIHEIG | AVGATKTERT | 
    1050:
    GIMQLKSEIK | QVEFRRLSIS | AESQSPGTSM | TPSSGSFPSA | YDQQSSKDSR | 
    1100:
    QGQWQRRRRL | DGALNRVPVG | FYQKVWKVLQ | KCHGLSVEGF | VLPSSTTREM | 
    1150:
    TPGEIKFSVH | VESVLNRVPQ | PEYRQLLVEA | ILVLTMLADI | EIHSIGSIIA | 
    1200:
    VEKIVHIAND | LFLQEQKTLG | ADDTMLAKDP | ASGICTLLYD | SAPSGRFGTM | 
    1223:
    TYLSKAAATY | VQEFLPHSIC | AMQ
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    Pfam:
    MIM:
    KEGG:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Human Phosphorylase kinase alpha M subunit
    ELISA Kit for Human Phosphorylase kinase alpha M subunit
    ELISA Kit for Human Phosphorylase kinase alpha M subunit
    ELISA Kit for Human Phosphorylase kinase alpha M subunit
    CLIA Kit for Human Phosphorylase kinase alpha M subunit
    CLIA Kit for Human Phosphorylase kinase alpha M subunit
    CLIA Kit for Human Phosphorylase kinase alpha M subunit
    CLIA Kit for Human Phosphorylase kinase alpha M subunit
    Polyclonal Antibody for Human Phosphorylase kinase alpha M subunit
    Polyclonal Antibody for Human Phosphorylase kinase alpha M subunit
    Polyclonal Antibody for Human Phosphorylase kinase alpha M subunit
    Polyclonal Antibody for Human Phosphorylase kinase alpha M subunit
    Monoclonal Antibody for Human Phosphorylase kinase alpha M subunit
    Monoclonal Antibody for Human Phosphorylase kinase alpha M subunit
    Monoclonal Antibody for Human Phosphorylase kinase alpha M subunit
    Monoclonal Antibody for Human Phosphorylase kinase alpha M subunit
    Protein for Human Phosphorylase kinase alpha M subunit
    Protein for Human Phosphorylase kinase alpha M subunit
    Protein for Human Phosphorylase kinase alpha M subunit
    Protein for Human Phosphorylase kinase alpha M subunit

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    Precision
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    Linearity
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    References
    1. 1.
      "The multiphosphorylation domain of the phosphorylase kinase alpha M and alpha L subunits is a hotspot of differential mRNA processing and of molecular evolution."
      Wuellrich A. , Hamacher C. , Schneider A. , Kilimann M.W.
      J. Biol. Chem.268:23208-23214(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2)
      tissue: Muscle.
    2. 2.
      "The DNA sequence of the human X chromosome."
      Ross M.T. , Grafham D.V. , Coffey A.J. , Scherer S. , McLay K. , Muzny D. , Platzer M. , Howell G.R. , Burrows C. , Bird C.P. , Frankish A. , Lovell F.L. , Howe K.L. , Ashurst J.L. , Fulton R.S. , Sudbrak R. , Wen G. , Jones M.C. , more...
      Nature434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    3. 3.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3)
      tissue: Brain.
    4. 4.
      "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H. , Olsen J.V. , Bairlein M. , Gnad F. , Oppermann F.S. , Korner R. , Greff Z. , Keri G. , Stemmann O. , Mann M.
      Mol. Cell31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-735;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    5. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-972 AND SER-985;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    6. 6.
      "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
      Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-758; SER-972 AND SER-985;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Leukemic T-cell.
    7. 7.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    8. 8.
      "Muscle glycogenosis with low phosphorylase kinase activity: mutations in PHKA1, PHKG1 or six other candidate genes explain only a minority of cases."
      Burwinkel B. , Hu B. , Schroers A. , Clemens P.R. , Moses S.W. , Shin Y.S. , Pongratz D. , Vorgerd M. , Kilimann M.W.
      Eur. J. Hum. Genet.11:516-526(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT GSD9D VAL-299
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