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Index > Protein center > Lif(Gene name) > Mouse
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  • Lif (Gene name),
  • Leukemia inhibitory factor (Protein name ),  LIF_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Lif;
    Protein name:
    Leukemia inhibitory factor(LIF);
    Alternative:
    Differentiation-stimulating factor(D factor);
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    LIF has the capacity to induce terminal differentiation in leukemic cells. Its activities include the induction of hematopoietic differentiation in normal and myeloid leukemia cells, the induction of neuronal cell differentiation, and the stimulation of acute-phase protein synthesis in hepatocytes.
    Subcellular Location:
    Secreted
    Protein Attributes:
    Sequence length:
    203
    Sequence:
    50:
    MKVLAAGIVP | LLLLVLHWKH | GAGSPLPITP | VNATCAIRHP | CHGNLMNQIK | 
    100:
    NQLAQLNGSA | NALFISYYTA | QGEPFPNNVE | KLCAPNMTDF | PSFHGNGTEK | 
    150:
    TKLVELYRMV | AYLSASLTNI | TRDQKVLNPT | AVSLQVKLNA | TIDVMRGLLS | 
    200:
    NVLCRLCNKY | RVGHVDVPPV | PDHSDKEAFQ | RKKLGCQLLG | TYKQVISVVV | 
    203:
    QAF
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    KEGG:
    Pfam:
    String:
    SMR:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse LIF
    Cat.:
    E0085h
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Mouse LIF
    Cat.:
    E0085m
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Mouse LIF
    Cat.:
    E0085b
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Mouse LIF
    Cat.:
    E0085r
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    MSDS:
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    Packing:
    96T
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    CLIA Kit for Mouse LIF
    Cat.:
    U0085r
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
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    CLIA Kit for Mouse LIF
    Cat.:
    U0085m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse LIF
    Cat.:
    U0085b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse LIF
    Cat.:
    U0085h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    Polyclonal Antibody for Mouse LIF
    Polyclonal Antibody for Mouse LIF
    Cat.:
    P0085Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse LIF
    Cat.:
    P0085Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse LIF
    Cat.:
    P0085Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Mouse LIF
    Monoclonal Antibody for Mouse LIF
    Monoclonal Antibody for Mouse LIF
    Monoclonal Antibody for Mouse LIF
    Protein for Mouse LIF
    Protein for Mouse LIF
    Protein for Mouse LIF
    Protein for Mouse LIF

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    Precision
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    Linearity
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    References
    1. 1.
      "Complete sequence of murine myeloid leukaemia inhibitory factor (LIF)."
      Gough N.M. , Gearing D.P. , King J.A.
      Nucleic Acids Res.16:9857-9857(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    2. 2.
      "Structural organization of the genes for murine and human leukemia inhibitory factor. Evolutionary conservation of coding and non-coding regions."
      Stahl J. , Gearing D.P. , Willson T.A. , Brown M.A. , King J.A. , Gough N.M.
      J. Biol. Chem.265:8833-8841(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    3. 3.
      "Sequence polymorphisms in the chemokines Scya1 (TCA-3), Scya2 (monocyte chemoattractant protein (MCP)-1), and Scya12 (MCP-5) are candidates for eae7, a locus controlling susceptibility to monophasic remitting/nonrelapsing experimental allergic encephalomyelitis."
      Teuscher C. , Butterfield R.J. , Ma R.Z. , Zachary J.F. , Doerge R.W. , Blankenhorn E.P.
      J. Immunol.163:2262-2266(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE
      strain: B10.S/J.
      strain: SJL/J.
      tissue: Spleen.
    4. 4.
      "Molecular cloning and expression of cDNA encoding a murine myeloid leukaemia inhibitory factor (LIF)."
      Gearing D.P. , Gough N.M. , King J.A. , Hilton D.J. , Nicola N.A. , Simpson R.J. , Nice E.C. , Kelso A. , Metcalf D.
      EMBO J.6:3995-4002(1987) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 17-203;PROTEIN SEQUENCE OF 195-203
    5. 5.
      "Biochemical characterization of murine leukaemia inhibitory factor produced by Krebs ascites and by yeast cells."
      Gough N.M. , Hilton D.J. , Gearing D.P. , Willson T.A. , King J.A. , Nicola N.A. , Metcalf D.
      Blood Cells14:431-442(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE OF 178-203
    6. 6.
      "Genomic cloning and heterologous expression of human differentiation-stimulating factor."
      Lowe D.G. , Nunes W. , Bombara M. , McCabe S. , Ranges G.E. , Henzel W. , Tomida M. , Yamamoto-Yamaguchi Y. , Hozumi M. , Goeddel D.V.
      DNA8:351-359(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 24-81 AND 108-176
    7. 7.
      "The disulfide bond arrangement of leukemia inhibitory factor: homology to oncostatin M and structural implications."
      Nicola N.A. , Cross B. , Simpson R.J.
      Biochem. Biophys. Res. Commun.190:20-26(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISULFIDE BONDS
    8. 8.
      "The crystal structure and biological function of leukemia inhibitory factor: implications for receptor binding."
      Robinson R.C. , Grey L.M. , Staunton D. , Vankelecom H. , Vernallis A.B. , Moreau J.-F. , Stuart D.I. , Heath J.K. , Jones E.Y.
      Cell77:1101-1116(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS)
    9. 9.
      "Solution dynamics and secondary structure of murine leukemia inhibitory factor: a four-helix cytokine with a rigid CD loop."
      Purvis D.H. , Mabbutt B.C.
      Biochemistry36:10146-10154(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR
    10. 10.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF HUMAN-MOUSE CHIMERA
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