Interacts with CECR2, HEBP2, MAP1S and UXT (By similarity). Interacts with PPARGC1A (By similarity). Interacts with FOXO1. Component of mRNP complexes associated with HNRPA1.
Function:
May play a role in RNA metabolism in both nuclei and mitochondria. In the nucleus binds to HNRPA1-associated poly(A) mRNAs and is part of nmRNP complexes at late stages of mRNA maturation which are possibly associated with nuclear mRNA export. May bind mature mRNA in the nucleus outer membrane. In mitochondria binds to poly(A) mRNA. Plays a role in translation or stability of mitochondrially encoded cytochrome c oxidase (COX) subunits. May be involved in transcription regulation. Cooperates with PPARGC1A to regulate certain mitochondrially encoded genes and gluconeogenic genes and may regulate docking of PPARGC1A to transcription factors. Seems to be involved in the transcription regulation of the multidrug-related genes MDR1 and MVP. Part of a nuclear factor that binds to the invMED1 element of MDR1 and MVP gene promoters (By similarity). Binds single-stranded DNA.
Monoclonal Antibody for Mouse Leucine-rich PPR motif-containing protein, mitochondrial
Monoclonal Antibody for Mouse Leucine-rich PPR motif-containing protein, mitochondrial
Monoclonal Antibody for Mouse Leucine-rich PPR motif-containing protein, mitochondrial
Protein for Mouse Leucine-rich PPR motif-containing protein, mitochondrial
Protein for Mouse Leucine-rich PPR motif-containing protein, mitochondrial
Protein for Mouse Leucine-rich PPR motif-containing protein, mitochondrial
R&D Technical Data
12% SDS-PAGE analysis
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Precision
Intra-assay Precision (Precision within an assay):Three samples of known concentration were tested twenty times on one plate to assess intra-assay precision.
Intra-Assay CV: ≤ 5.4%
Inter-assay Precision (Precision between assays):Three samples of known concentration were tested in five separate assays to assess inter-assay precision.
Inter-Assay CV: ≤ 8.7%
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Recovery
Recovery was determined by spiking various levels of ACE into serum and plasma .
Sample Type
Average(%)
Recovery Range(%)
Serum
97
93-102
Plasma
99
95-105
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Linearity
The linearity of the kit was assayed by testing samples spiked with appropriate concentration of ACE and their serial dilutions. The results were demonstrated by the percentage of calculated concentration to the expected.
Sample
1:2
1:4
1:8
1:16
serum(n=5)
88-103%
88-101%
91-105%
89-103%
EDTA plasma(n=5)
87-97%
91-103%
92-101%
88-105%
heparin plasma(n=5)
90-104%
94-108%
101-106%
91-109%
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Cited for: NUCLEOTIDE SEQUENCE [MRNA];IDENTIFICATION BY MASS SPECTROMETRY;DNA-BINDING;SUBCELLULAR LOCATION;TISSUE SPECIFICITY;DEVELOPMENTAL STAGE
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 681-1392
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-151; LYS-186; LYS-225 AND LYS-462;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]