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Index > Protein center > Lrpprc(Gene name) > Mouse
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  • Lrpprc (Gene name),
  • Leucine-rich PPR motif-containing protein, mitochondrial (Protein name ),  LPPRC_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    Lrpprc(Lrp130);
    Protein name:
    Leucine-rich PPR motif-containing protein, mitochondrial;
    Alternative:
    130 kDa leucine-rich protein(LRP 130;mLRP130);
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Interacts with CECR2, HEBP2, MAP1S and UXT (By similarity). Interacts with PPARGC1A (By similarity). Interacts with FOXO1. Component of mRNP complexes associated with HNRPA1.
    Function:
    May play a role in RNA metabolism in both nuclei and mitochondria. In the nucleus binds to HNRPA1-associated poly(A) mRNAs and is part of nmRNP complexes at late stages of mRNA maturation which are possibly associated with nuclear mRNA export. May bind mature mRNA in the nucleus outer membrane. In mitochondria binds to poly(A) mRNA. Plays a role in translation or stability of mitochondrially encoded cytochrome c oxidase (COX) subunits. May be involved in transcription regulation. Cooperates with PPARGC1A to regulate certain mitochondrially encoded genes and gluconeogenic genes and may regulate docking of PPARGC1A to transcription factors. Seems to be involved in the transcription regulation of the multidrug-related genes MDR1 and MVP. Part of a nuclear factor that binds to the invMED1 element of MDR1 and MVP gene promoters (By similarity). Binds single-stranded DNA.
    Subcellular Location:
    Mitochondrion Nucleus Nucleus nucleoplasm Nucleus inner membrane Nucleus outer membrane
    Protein Attributes:
    Sequence length:
    1392
    Sequence:
    50:
    MAALLRPARW | LLGAAAAPRL | PLSLRLPAGV | PGRLSSVVRV | AAVGSRPAAG | 
    100:
    ERLSQARLYA | IVAEKRDLQE | EPAPVRKNSS | QFDWALMRLD | NSVRRTGRIT | 
    150:
    KGLLQRVFES | TCSSGSPGSN | QALLLLRSCG | SLLPELSLAE | RTEFAHKIWD | 
    200:
    KLQQLGVVYD | VSHYNALLKV | YLQNEYKFSP | TDFLAKMEGA | NIQPNRVTYQ | 
    250:
    RLIAAYCNVG | DIEGASKILG | FMKTKDLPIT | EAVFSALVTG | HARAGDMENA | 
    300:
    ENILTVMKQA | GIEPGPDTYL | ALLNAHAERG | DIGQVRQILE | KVEKSDHYFM | 
    350:
    DRDFLQVIFS | FSKAGYPQYV | SEILEKITYE | RRSIPDAMNL | ILFLATEKLE | 
    400:
    DTAFQVLLAL | PLSKDESSDN | FGSFFLRHCV | TLDLPPEKLI | DYCRRLRDAK | 
    450:
    LHSSSLQFTL | HCALQANRTA | LAKAVMEALR | EEGFPIRPHY | FWPLLAGHQK | 
    500:
    TKNVQGIIDI | LKIMNKVGVD | PDQETYINYV | FPCFDSAQSV | RAALQENECL | 
    550:
    LASSTFAQAE | VKNEAINGNL | QNILSFLESN | TLPFSFSSLR | NSLILGFRRS | 
    600:
    MNIDLWSKIT | ELLYKDERYC | SKPPGPAEAV | GYFLYNLIDS | MSDSEVQAKE | 
    650:
    ERLRQYFHQL | QEMNVKVPEN | IYKGICNLLN | TYHVPELIKD | IKVLVDREKV | 
    700:
    DSQKTSQVTS | SDLESTLEKL | KAEGQPVGSA | LKQLLLLLCS | EENMQKALEV | 
    750:
    KAKYESDMVI | GGYAALINLC | CRHDNAEDAW | NLKQEVDRLD | ASAILDTAKY | 
    800:
    VALVKVLGKH | SRLQDAINIL | KEMKEKDVVI | KDATVLSFFH | ILNGAALRGE | 
    850:
    IETVKQLHEA | IVTLGLAKPS | SNISFPLVTV | HLEKGDLPAA | LEASIACHKK | 
    900:
    YKVLPRIHDV | LCKLVEKGET | DLIQKAMDFV | SQEQGEMTML | YDLFFAFLQT | 
    950:
    GNYKEAKKII | ETPGIRARPT | RLQWFCDRCI | ASNQVEALEK | LVELTEKLFE | 
    1000:
    CDRDQMYYNL | LKLYKISSDW | QRADAAWTKM | QEENIIPRER | TLRLLAEILK | 
    1050:
    TSNQEVPFDV | PELWFGDDRP | SLSPSSRSAG | EDVTEKTLLS | NCKLKKSKDA | 
    1100:
    YNIFLKAEKQ | NVVFSSETYS | TLIGLLLSKD | DFTQAMHVKD | FAETHIKGFT | 
    1150:
    LNDAANSLLI | IRQVRRDYLK | GALATLRAAL | DLKQVPSQIA | VTRLIQALAL | 
    1200:
    KGDVESIEAI | QRMVAGLDTI | GLSKMVFINN | IALAQMKNNK | LDAAIENIEH | 
    1250:
    LLASENQAIE | PQYFGLSYLF | RKVIEEQMEP | ALEKLSIMSE | RMANQFALYK | 
    1300:
    PVTDLFLQLV | DSGKVDEARA | LLERCGAIAE | QSSLLSVFCL | RTSQKPKKAP | 
    1350:
    VLKTLLELIP | ELRDNDKVYS | CSMKSYALDK | DVASAKALYE | YLTAKNLKLD | 
    1392:
    DLFLKRYAAL | LKDVGEPVPF | PEPPESFAFY | IKQLKEARES | PS
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    SMR:
    Pfam:
    UniGene:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Leucine-rich PPR motif-containing protein, mitochondrial
    Cat.:
    E14393h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Mouse Leucine-rich PPR motif-containing protein, mitochondrial
    Cat.:
    E14393m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Mouse Leucine-rich PPR motif-containing protein, mitochondrial
    Cat.:
    E14393r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Leucine-rich PPR motif-containing protein, mitochondrial
    Cat.:
    U14393r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Leucine-rich PPR motif-containing protein, mitochondrial
    Cat.:
    U14393h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Leucine-rich PPR motif-containing protein, mitochondrial
    Cat.:
    U14393m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Mouse Leucine-rich PPR motif-containing protein, mitochondrial
    Cat.:
    P14393Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse Leucine-rich PPR motif-containing protein, mitochondrial
    Cat.:
    P14393Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse Leucine-rich PPR motif-containing protein, mitochondrial
    Cat.:
    P14393Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Mouse Leucine-rich PPR motif-containing protein, mitochondrial
    Monoclonal Antibody for Mouse Leucine-rich PPR motif-containing protein, mitochondrial
    Monoclonal Antibody for Mouse Leucine-rich PPR motif-containing protein, mitochondrial
    Protein for Mouse Leucine-rich PPR motif-containing protein, mitochondrial
    Protein for Mouse Leucine-rich PPR motif-containing protein, mitochondrial
    Protein for Mouse Leucine-rich PPR motif-containing protein, mitochondrial

    R&D Technical Data

             12% SDS-PAGE analysis

    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    Precision

    Intra-assay Precision (Precision within an assay):Three samples of known concentration were tested twenty times on one plate to assess intra-assay precision.

    Intra-Assay CV: ≤ 5.4%

    Inter-assay Precision (Precision between assays):Three samples of known concentration were tested in five separate assays to assess inter-assay precision.

    Inter-Assay CV: ≤ 8.7%

    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    Recovery

    Recovery was determined by spiking various levels of ACE into serum and plasma .

    Sample Type

    Average(%)

    Recovery Range(%)

    Serum

    97

    93-102

    Plasma

    99

    95-105

     

     

     

     

    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    Linearity

     

    The linearity of the kit was assayed by testing samples spiked with appropriate concentration of ACE and their serial dilutions. The results were demonstrated by the percentage of calculated concentration to the expected.  

     

    Sample

    1:2

    1:4

    1:8

    1:16

    serum(n=5)

    88-103%

    88-101%

    91-105%

    89-103%

    EDTA plasma(n=5)

    87-97%

    91-103%

    92-101%

    88-105%

    heparin plasma(n=5)

    90-104%

     

    94-108%

    101-106%

    91-109%

     

    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    References
    1. 1.
      "LRP130, a protein containing nine pentatricopeptide repeat motifs, interacts with a single-stranded cytosine-rich sequence of mouse hypervariable minisatellite Pc-1."
      Tsuchiya N. , Fukuda H. , Sugimura T. , Nagao M. , Nakagama H.
      Eur. J. Biochem.269:2927-2933(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];IDENTIFICATION BY MASS SPECTROMETRY;DNA-BINDING;SUBCELLULAR LOCATION;TISSUE SPECIFICITY;DEVELOPMENTAL STAGE
    2. 2.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: C57BL/6.
      tissue: Brain.
    3. 3.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 681-1392
      strain: C57BL/6J.
      tissue: Head.
    4. 4.
      "LRP130, a single-stranded DNA/RNA-binding protein, localizes at the outer nuclear and endoplasmic reticulum membrane, and interacts with mRNA in vivo."
      Tsuchiya N. , Fukuda H. , Nakashima K. , Nagao M. , Sugimura T. , Nakagama H.
      Biochem. Biophys. Res. Commun.317:736-743(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: RNA-BINDING
    5. 5.
      "Defects in energy homeostasis in Leigh syndrome French Canadian variant through PGC-1alpha/LRP130 complex."
      Cooper M.P. , Qu L. , Rohas L.M. , Lin J. , Yang W. , Erdjument-Bromage H. , Tempst P. , Spiegelman B.M.
      Genes Dev.20:2996-3009(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH FOXO1
    6. 6.
      "Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways."
      Rardin M.J. , Newman J.C. , Held J.M. , Cusack M.P. , Sorensen D.J. , Li B. , Schilling B. , Mooney S.D. , Kahn C.R. , Verdin E. , Gibson B.W.
      Proc. Natl. Acad. Sci. U.S.A.110:6601-6606(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-151; LYS-186; LYS-225 AND LYS-462;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Liver.
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