Protein name:
Low-density lipoprotein receptor-related protein 2(LRP-2);
Alternative:
Megalin;Glycoprotein 330(gp330);
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Binds plasminogen, extracellular matrix components, plasminogen activator-plasminogen activator inhibitor type I complex, apolipoprotein E-enriched beta-VLDL, lipoprotein lipase, lactoferrin, CLU/clusterin and calcium. Forms a multimeric complex together with a receptor-associated protein (RAP). Binds to ankyrin-repeat family A protein 2 (ANKRA2). Interacts with LRP2BP.
Function:
Acts together with cubilin to mediate HDL endocytosis (By similarity). May participate in regulation of parathyroid-hormone and para-thyroid-hormone-related protein release.
Subcellular Location:
Membrane
Single-pass type I membrane protein
Membrane
coated pit
Protein Attributes:
50:
MDRGPAAVAC | TLLLALVACL | APASGQECDS | AHFRCGSGHC | IPADWRCDGT |
100:
KDCSDDADEI | GCAVVTCQQG | YFKCQSEGQC | IPNSWVCDQD | QDCDDGSDER |
150:
QDCSQSTCSS | HQITCSNGQC | IPSEYRCDHV | RDCPDGADEN | DCQYPTCEQL |
200:
TCDNGACYNT | SQKCDWKVDC | RDSSDEINCT | EICLHNEFSC | GNGECIPRAY |
250:
VCDHDNDCQD | GSDEHACNYP | TCGGYQFTCP | SGRCIYQNWV | CDGEDDCKDN |
300:
GDEDGCESGP | HDVHKCSPRE | WSCPESGRCI | SIYKVCDGIL | DCPGREDENN |
350:
TSTGKYCSMT | LCSALNCQYQ | CHETPYGGAC | FCPPGYIINH | NDSRTCVEFD |
400:
DCQIWGICDQ | KCESRPGRHL | CHCEEGYILE | RGQYCKANDS | FGEASIIFSN |
450:
GRDLLIGDIH | GRSFRILVES | QNRGVAVGVA | FHYHLQRVFW | TDTVQNKVFS |
500:
VDINGLNIQE | VLNVSVETPE | NLAVDWVNNK | IYLVETKVNR | IDMVNLDGSY |
550:
RVTLITENLG | HPRGIAVDPT | VGYLFFSDWE | SLSGEPKLER | AFMDGSNRKD |
600:
LVKTKLGWPA | GVTLDMISKR | VYWVDSRFDY | IETVTYDGIQ | RKTVVHGGSL |
650:
IPHPFGVSLF | EGQVFFTDWT | KMAVLKANKF | TETNPQVYYQ | ASLRPYGVTV |
700:
YHSLRQPYAT | NPCKDNNGGC | EQVCVLSHRT | DNDGLGFRCK | CTFGFQLDTD |
750:
ERHCIAVQNF | LIFSSQVAIR | GIPFTLSTQE | DVMVPVSGNP | SFFVGIDFDA |
800:
QDSTIFFSDM | SKHMIFKQKI | DGTGREILAA | NRVENVESLA | FDWISKNLYW |
850:
TDSHYKSISV | MRLADKTRRT | VVQYLNNPRS | VVVHPFAGYL | FFTDWFRPAK |
900:
IMRAWSDGSH | LLPVINTTLG | WPNGLAIDWA | ASRLYWVDAY | FDKIEHSTFD |
950:
GLDRRRLGHI | EQMTHPFGLA | IFGEHLFFTD | WRLGAIIRVR | KADGGEMTVI |
1000:
RSGIAYILHL | KSYDVNIQTG | SNACNQPTHP | NGDCSHFCFP | VPNFQRVCGC |
1050:
PYGMRLASNH | LTCEGDPTNE | PPTEQCGLFS | FPCKNGRCVP | NYYLCDGVDD |
1100:
CHDNSDEQLC | GTLNNTCSSS | AFTCGHGECI | PAHWRCDKRN | DCVDGSDEHN |
1150:
CPTHAPASCL | DTQYTCDNHQ | CISKNWVCDT | DNDCGDGSDE | KNCNSTETCQ |
1200:
PSQFNCPNHR | CIDLSFVCDG | DKDCVDGSDE | VGCVLNCTAS | QFKCASGDKC |
1250:
IGVTNRCDGV | FDCSDNSDEA | GCPTRPPGMC | HSDEFQCQED | GICIPNFWEC |
1300:
DGHPDCLYGS | DEHNACVPKT | CPSSYFHCDN | GNCIHRAWLC | DRDNDCGDMS |
1350:
DEKDCPTQPF | RCPSWQWQCL | GHNICVNLSV | VCDGIFDCPN | GTDESPLCNG |
1400:
NSCSDFNGGC | THECVQEPFG | AKCLCPLGFL | LANDSKTCED | IDECDILGSC |
1450:
SQHCYNMRGS | FRCSCDTGYM | LESDGRTCKV | TASESLLLLV | ASQNKIIADS |
1500:
VTSQVHNIYS | LVENGSYIVA | VDFDSISGRI | FWSDATQGKT | WSAFQNGTDR |
1550:
RVVFDSSIIL | TETIAIDWVG | RNLYWTDYAL | ETIEVSKIDG | SHRTVLISKN |
1600:
LTNPRGLALD | PRMNEHLLFW | SDWGHHPRIE | RASMDGSMRT | VIVQDKIFWP |
1650:
CGLTIDYPNR | LLYFMDSYLD | YMDFCDYNGH | HRRQVIASDL | IIRHPYALTL |
1700:
FEDSVYWTDR | ATRRVMRANK | WHGGNQSVVM | YNIQWPLGIV | AVHPSKQPNS |
1750:
VNPCAFSRCS | HLCLLSSQGP | HFYSCVCPSG | WSLSPDLLNC | LRDDQPFLIT |
1800:
VRQHIIFGIS | LNPEVKSNDA | MVPIAGIQNG | LDVEFDDAEQ | YIYWVENPGE |
1850:
IHRVKTDGTN | RTVFASISMV | GPSMNLALDW | ISRNLYSTNP | RTQSIEVLTL |
1900:
HGDIRYRKTL | IANDGTALGV | GFPIGITVDP | ARGKLYWSDQ | GTDSGVPAKI |
1950:
ASANMDGTSV | KTLFTGNLEH | LECVTLDIEE | QKLYWAVTGR | GVIERGNVDG |
2000:
TDRMILVHQL | SHPWGIAVHD | SFLYYTDEQY | EVIERVDKAT | GANKIVLRDN |
2050:
VPNLRGLQVY | HRRNAAESSN | GCSNNMNACQ | QICLPVPGGL | FSCACATGFK |
2100:
LNPDNRSCSP | YNSFIVVSML | SAIRGFSLEL | SDHSETMVPV | AGQGRNALHV |
2150:
DVDVSSGFIY | WCDFSSSVAS | DNAIRRIKPD | GSSLMNIVTH | GIGENGVRGI |
2200:
AVDWVAGNLY | FTNAFVSETL | IEVLRINTTY | RRVLLKVTVD | MPRHIVVDPK |
2250:
NRYLFWADYG | QRPKIERSFL | DCTNRTVLVS | EGIVTPRGLA | VDRSDGYVYW |
2300:
VDDSLDIIAR | IRINGENSEV | IRYGSRYPTP | YGITVFENSI | IWVDRNLKKI |
2350:
FQASKEPENT | EPPTVIRDNI | NWLRDVTIFD | KQVQPRSPAE | VNNNPCLENN |
2400:
GGCSHLCFAL | PGLHTPKCDC | AFGTLQSDGK | NCAISTENFL | IFALSNSLRS |
2450:
LHLDPENHSP | PFQTINVERT | VMSLDYDSVS | DRIYFTQNLA | SGVGQISYAT |
2500:
LSSGIHTPTV | IASGIGTADG | IAFDWITRRI | YYSDYLNQMI | NSMAEDGSNR |
2550:
TVIARVPKPR | AIVLDPCQGY | LYWADWDTHA | KIERATLGGN | FRVPIVNSSL |
2600:
VMPSGLTLDY | EEDLLYWVDA | SLQRIERSTL | TGVDREVIVN | AAVHAFGLTL |
2650:
YGQYIYWTDL | YTQRIYRANK | YDGSGQIAMT | TNLLSQPRGI | NTVVKNQKQQ |
2700:
CNNPCEQFNG | GCSHICAPGP | NGAECQCPHE | GNWYLANNRK | HCIVDNGERC |
2750:
GASSFTCSNG | RCISEEWKCD | NDNDCGDGSD | EMESVCALHT | CSPTAFTCAN |
2800:
GRCVQYSYRC | DYYNDCGDGS | DEAGCLFRDC | NATTEFMCNN | RRCIPREFIC |
2850:
NGVDNCHDNN | TSDEKNCPDR | TCQSGYTKCH | NSNICIPRVY | LCDGDNDCGD |
2900:
NSDENPTYCT | THTCSSSEFQ | CASGRCIPQH | WYCDQETDCF | DASDEPASCG |
2950:
HSERTCLADE | FKCDGGRCIP | SEWICDGDND | CGDMSDEDKR | HQCQNQNCSD |
3000:
SEFLCVNDRP | PDRRCIPQSW | VCDGDVDCTD | GYDENQNCTR | RTCSENEFTC |
3050:
GYGLCIPKIF | RCDRHNDCGD | YSDERGCLYQ | TCQQNQFTCQ | NGRCISKTFV |
3100:
CDEDNDCGDG | SDELMHLCHT | PEPTCPPHEF | KCDNGRCIEM | MKLCNHLDDC |
3150:
LDNSDEKGCG | INECHDPSIS | GCDHNCTDTL | TSFYCSCRPG | YKLMSDKRTC |
3200:
VDIDECTEMP | FVCSQKCENV | IGSYICKCAP | GYLREPDGKT | CRQNSNIEPY |
3250:
LIFSNRYYLR | NLTIDGYFYS | LILEGLDNVV | ALDFDRVEKR | LYWIDTQRQV |
3300:
IERMFLNKTN | KETIINHRLP | AAESLAVDWV | SRKLYWLDAR | LDGLFVSDLN |
3350:
GGHRRMLAQH | CVDANNTFCF | DNPRGLALHP | QYGYLYWADW | GHRAYIGRVG |
3400:
MDGTNKSVII | STKLEWPNGI | TIDYTNDLLY | WADAHLGYIE | YSDLEGHHRH |
3450:
TVYDGALPHP | FAITIFEDTI | YWTDWNTRTV | EKGNKYDGSN | RQTLVNTTHR |
3500:
PFDIHVYHPY | RQPIVSNPCG | TNNGGCSHLC | LIKPGGKGFT | CECPDDFRTL |
3550:
QLSGSTYCMP | MCSSTQFLCA | NNEKCIPIWW | KCDGQKDCSD | GSDELALCPQ |
3600:
RFCRLGQFQC | SDGNCTSPQT | LCNAHQNCPD | GSDEDRLLCE | NHHCDSNEWQ |
3650:
CANKRCIPES | WQCDTFNDCE | DNSDEDSSHC | ASRTCRPGQF | RCANGRCIPQ |
3700:
AWKCDVDNDC | GDHSDEPIEE | CMSSAHLCDN | FTEFSCKTNY | RCIPKWAVCN |
3750:
GVDDCRDNSD | EQGCEERTCH | PVGDFRCKNH | HCIPLRWQCD | GQNDCGDNSD |
3800:
EENCAPRECT | ESEFRCVNQQ | CIPSRWICDH | YNDCGDNSDE | RDCEMRTCHP |
3850:
EYFQCTSGHC | VHSELKCDGS | ADCLDASDEA | DCPTRFPDGA | YCQATMFECK |
3900:
NHVCIPPYWK | CDGDDDCGDG | SDEELHLCLD | VPCNSPNRFR | CDNNRCIYSH |
3950:
EVCNGVDDCG | DGTDETEEHC | RKPTPKPCTE | YEYKCGNGHC | IPHDNVCDDA |
4000:
DDCGDWSDEL | GCNKGKERTC | AENICEQNCT | QLNEGGFICS | CTAGFETNVF |
4050:
DRTSCLDINE | CEQFGTCPQH | CRNTKGSYEC | VCADGFTSMS | DRPGKRCAAE |
4100:
GSSPLLLLPD | NVRIRKYNLS | SERFSEYLQD | EEYIQAVDYD | WDPKDIGLSV |
4150:
VYYTVRGEGS | RFGAIKRAYI | PNFESGRNNL | VQEVDLKLKY | VMQPDGIAVD |
4200:
WVGRHIYWSD | VKNKRIEVAK | LDGRYRKWLI | STDLDQPAAI | AVNPKLGLMF |
4250:
WTDWGKEPKI | ESAWMNGEDR | NILVFEDLGW | PTGLSIDYLN | NDRIYWSDFK |
4300:
EDVIETIKYD | GTDRRVIAKE | AMNPYSLDIF | EDQLYWISKE | KGEVWKQNKF |
4350:
GQGKKEKTLV | VNPWLTQVRI | FHQLRYNKSV | PNLCKQICSH | LCLLRPGGYS |
4400:
CACPQGSSFI | EGSTTECDAA | IELPINLPPP | CRCMHGGNCY | FDETDLPKCK |
4450:
CPSGYTGKYC | EMAFSKGISP | GTTAVAVLLT | ILLIVVIGAL | AIAGFFHYRR |
4500:
TGSLLPALPK | LPSLSSLVKP | SENGNGVTFR | SGADLNMDIG | VSGFGPETAI |
4550:
DRSMAMSEDF | VMEMGKQPII | FENPMYSARD | SAVKVVQPIQ | VTVSENVDNK |
4600:
NYGSPINPSE | IVPETNPTSP | AADGTQVTKW | NLFKRKSKQT | TNFENPIYAQ |
4650:
MENEQKESVA | ATPPPSPSLP | AKPKPPSRRD | PTPTYSATED | TFKDTANLVK |
Vaild Sequence:
Related Databases
Uniprot: