Protein name:
Low-density lipoprotein receptor-related protein 2(LRP-2);
Alternative:
Megalin;Glycoprotein 330(gp330);
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Binds plasminogen, extracellular matrix components, plasminogen activator-plasminogen activator inhibitor type I complex, apolipoprotein E-enriched beta-VLDL, lipoprotein lipase, lactoferrin, CLU/clusterin and calcium. Forms a multimeric complex together with a receptor-associated protein (RAP). Binds to ankyrin-repeat family A protein 2 (ANKRA2). Interacts with LRP2BP.
Function:
Acts together with cubilin to mediate HDL endocytosis.
Subcellular Location:
Membrane
Single-pass type I membrane protein
Membrane
coated pit
Protein Attributes:
50:
MERGAAAAAW | MLLLAIAACL | APVSGQECGS | GNFRCDNGYC | IPASWRCDGT |
100:
RDCLDDTDEI | GCPPRSCGSG | FFLCPAEGTC | IPSSWVCDQD | KDCSDGADEQ |
150:
QNCPGTTCSS | QQLTCSNGQC | VPIEYRCDHV | SDCPDGSDER | NCYYPTCDQL |
200:
TCANGACYNT | SQKCDHKVDC | RDSSDEANCT | TLCSQKEFQC | GSGECILRAY |
250:
VCDHDNDCED | NSDEHNCNYD | TCGGHQFTCS | NGQCINQNWV | CDGDDDCQDS |
300:
GDEDGCESNQ | RHHTCYPREW | ACPGSGRCIS | MDKVCDGVPD | CPEGEDENNA |
350:
TSGRYCGTGL | CSILNCEYQC | HQTPYGGECF | CPPGHIINSN | DSRTCIDFDD |
400:
CQIWGICDQK | CESRQGRHQC | LCEEGYILER | GQHCKSNDSF | SAASIIFSNG |
450:
RDLLVGDLHG | RNFRILAESK | NRGIVMGVDF | HYQKHRVFWT | DPMQAKVFST |
500:
DINGLNTQEI | LNVSIDAPEN | LAVDWINNKL | YLVETRVNRI | DVVNLEGNQR |
550:
VTLITENLGH | PRGIALDPTV | GYLFFSDWGS | LSGQPKVERA | FMDGSNRKDL |
600:
VTTKLGWPAG | ITLDLVSKRV | YWVDSRYDYI | ETVTYDGIQR | KTVARGGSLV |
650:
PHPFGISLFE | EHVFFTDWTK | MAVMKANKFT | DTNPQVYHQS | SLTPFGVTVY |
700:
HALRQPNATN | PCGNNNGGCA | QICVLSHRTD | NGGLGYRCKC | EFGFELDADE |
750:
HHCVAVKNFL | LFSSQTAVRG | IPFTLSTQED | VMVPVTGSPS | FFVGIDFDAQ |
800:
HSTIFYSDLS | KNIIYQQKID | GTGKEVITAN | RLQNVECLSF | DWISRNLYWT |
850:
DGGSKSVTVM | KLADKSRRQI | ISNLNNPRSI | VVHPAAGYMF | LSDWFRPAKI |
900:
MRAWSDGSHL | MPIVNTSLGW | PNGLAIDWST | SRLYWVDAFF | DKIEHSNLDG |
950:
LDRKRLGHVD | QMTHPFGLTV | FKDNVFLTDW | RLGAIIRVRK | SDGGDMTVVR |
1000:
RGISSIMHVK | AYDADLQTGT | NYCSQTTHPN | GDCSHFCFPV | PNFQRVCGCP |
1050:
YGMKLQRDQM | TCEGDPAREP | PTQQCGSSSF | PCNNGKCVPS | IFRCDGVDDC |
1100:
HDNSDEHQCG | ALNNTCSSSA | FTCVHGGQCI | PGQWRCDKQN | DCLDGSDEQN |
1150:
CPTRSPSSTC | PPTSFTCDNH | MCIPKEWVCD | TDNDCSDGSD | EKNCQASGTC |
1200:
HPTQFRCPDH | RCISPLYVCD | GDKDCVDGSD | EAGCVLNCTS | SQFKCADGSS |
1250:
CINSRYRCDG | VYDCKDNSDE | AGCPTRPPGM | CHPDEFQCQG | DGTCIPNTWE |
1300:
CDGHPDCIQG | SDEHNGCVPK | TCSPSHFLCD | NGNCIYNSWV | CDGDNDCRDM |
1350:
SDEKDCPTQP | FHCPSSQWQC | PGYSICVNLS | ALCDGVFDCP | NGTDESPLCN |
1400:
QDSCLHFNGG | CTHRCIQGPF | GATCVCPIGY | QLANDTKTCE | DVNECDIPGF |
1450:
CSQHCVNMRG | SFRCACDPEY | TLESDGRTCK | VTASENLLLV | VASRDKIIMD |
1500:
NITAHTHNIY | SLVQDVSFVV | ALDFDSVTGR | VFWSDLLEGK | TWSAFQNGTD |
1550:
KRVVHDSGLS | LTEMIAVDWI | GRNIYWTDYT | LETIEVSKID | GSHRTVLISK |
1600:
NVTKPRGLAL | DPRMGDNVMF | WSDWGHHPRI | ERASMDGTMR | TVIVQEKIYW |
1650:
PCGLSIDYPN | RLIYFMDAYL | DYIEFCDYDG | QNRRQVIASD | LVLHHPHALT |
1700:
LFEDSVFWTD | RGTHQVMQAN | KWHGRNQSVV | MYSVPQPLGI | IAIHPSRQPS |
1750:
SPNPCASATC | SHLCLLSAQE | PRHYSCACPS | GWNLSDDSVN | CVRGDQPFLI |
1800:
SVRENVIFGI | SLDPEVKSND | AMVPISGIQH | GYDVEFDDSE | QFIYWVENPG |
1850:
EIHRVKTDGS | NRTAFAPLSL | LGSSLGLALD | WVSRNIYYTT | PASRSIEVLT |
1900:
LRGDTRYGKT | LITNDGTPLG | VGFPVGIAVD | PARGKLYWSD | HGTDSGVPAK |
1950:
IASANMDGTS | LKILFTGNME | HLEVVTLDIQ | EQKLYWAVTS | RGVIERGNVD |
2000:
GTERMILVHH | LAHPWGLVVH | GSFLYYSDEQ | YEVIERVDKS | SGSNKVVFRD |
2050:
NIPYLRGLRV | YHHRNAADSS | NGCSNNPNAC | QQICLPVPGG | MFSCACASGF |
2100:
KLSPDGRSCS | PYNSFIVVSM | LPAVRGFSLE | LSDHSEAMVP | VAGQGRNVLH |
2150:
ADVDVANGFI | YWCDFSSSVR | SSNGIRRIKP | NGSNFTNIVT | YGIGANGIRG |
2200:
VAVDWVAGNL | YFTNAFVYET | LIEVIRINTT | YRRVLLKVSV | DMPRHIVVDP |
2250:
KHRYLFWADY | GQKPKIERSF | LDCTNRTVLV | SEGIVTPRGL | AVDHDTGYIY |
2300:
WVDDSLDIIA | RIHRDGGESQ | VVRYGSRYPT | PYGITVFGES | IIWVDRNLRK |
2350:
VFQASKQPGN | TDPPTVIRDS | INLLRDVTIF | DEHVQPLSPA | ELNNNPCLQS |
2400:
NGGCSHFCFA | LPELPTPKCG | CAFGTLEDDG | KNCATSREDF | LIYSLNNSLR |
2450:
SLHFDPQDHN | LPFQAISVEG | MAIALDYDRR | NNRIFFTQKL | NPIRGQISYV |
2500:
NLYSGASSPT | ILLSNIGVTD | GIAFDWINRR | IYYSDFSNQT | INSMAEDGSN |
2550:
RAVIARVSKP | RAIVLDPCRG | YMYWTDWGTN | AKIERATLGG | NFRVPIVNTS |
2600:
LVWPNGLTLD | LETDLLYWAD | ASLQKIERST | LTGSNREVVI | STAFHSFGLT |
2650:
VYGQYIYWTD | FYTKKIYRAN | KYDGSDLIAM | TTRLPTQPSG | ISTVVKTQQQ |
2700:
QCSNPCDQFN | GGCSHICAPG | PNGAECQCPH | EGSWYLANDN | KYCVVDTGAR |
2750:
CNQFQFTCLN | GRCISQDWKC | DNDNDCGDGS | DELPTVCAFH | TCRSTAFTCA |
2800:
NGRCVPYHYR | CDFYNDCGDN | SDEAGCLFRS | CNSTTEFTCS | NGRCIPLSYV |
2850:
CNGINNCHDN | DTSDEKNCPP | ITCQPDFAKC | QTTNICVPRA | FLCDGDNDCG |
2900:
DGSDENPIYC | ASHTCRSNEF | QCVSPHRCIP | SYWFCDGEAD | CVDSSDEPDT |
2950:
CGHSLNSCSA | NQFHCDNGRC | ISSSWVCDGD | NDCGDMSDED | QRHHCELQNC |
3000:
SSTEFTCINS | RPPNRRCIPQ | HWVCDGDADC | ADALDELQNC | TMRACSTGEF |
3050:
SCANGRCIRQ | SFRCDRRNDC | GDYSDERGCS | YPPCRDDQFT | CQNGQCITKL |
3100:
YVCDEDNDCG | DGSDEQEHLC | HTPEPTCPPH | QFRCDNGHCI | EMGTVCNHVD |
3150:
DCSDNSDEKG | CGINECQDSS | ISHCDHNCTD | TITSFYCSCL | PGYKLMSDKR |
3200:
TCVDIDECKE | TPQLCSQKCE | NVIGSYICKC | APGYIREPDG | KSCRQNSNIE |
3250:
PYLVFSNRYY | IRNLTIDGTS | YSLILQGLGN | VVALDFDRVE | ERLYWIDAEK |
3300:
QIIERMFLNK | TNQETIISHR | LRRAESLAVD | WVSRKLYWLD | AILDCLFVSD |
3350:
LEGRQRKMLA | QHCVDANNTF | CFENPRGIVL | HPQRGYVYWA | DWGDHAYIAR |
3400:
IGMDGTNKTV | IISTKIEWPN | AITIDYTNDL | LYWADAHLGY | IEFSDLEGHH |
3450:
RHTVYDGTLP | HPFALTIFED | TVFWTDWNTR | TVEKGNKYDG | SGRVVLVNTT |
3500:
HKPFDIHVLH | PYRQPIMSNP | CATNNGGCSH | LCLIKAGGRG | FTCECPDDFQ |
3550:
TVQLRDRTLC | MPMCSSTQFL | CGNNEKCIPI | WWKCDGQKDC | SDGSDESDLC |
3600:
PHRFCRLGQF | QCRDGNCTSP | QALCNARQDC | ADGSDEDRVL | CEHHRCEANE |
3650:
WQCANKRCIP | EYWQCDSVDD | CLDNSDEDPS | HCASRTCRPG | QFKCNNGRCI |
3700:
PQSWKCDVDN | DCGDYSDEPI | HECMTAAYNC | DNHTEFSCKT | NYRCIPQWAV |
3750:
CNGFDDCRDN | SDEQGCESVP | CHPSGDFRCG | NHHCIPLRWK | CDGIDDCGDN |
3800:
SDEESCVPRE | CTESEFRCAD | QQCIPSRWVC | DQENDCGDNS | DERDCEMKTC |
3850:
HPEHFQCTSG | HCVPKALACD | GRADCLDASD | ESACPTRFPN | GTYCPAAMFE |
3900:
CKNHVCIQSF | WICDGENDCV | DGSDEEIHLC | FNVPCESPQR | FRCDNSRCIY |
3950:
GHQLCNGVDD | CGDGSDEKEE | HCRKPTHKPC | TDTEYKCSNG | NCVSQHYVCD |
4000:
NVDDCGDLSD | ETGCNLGENR | TCAEKICEQN | CTQLSNGGFI | CSCRPGFKPS |
4050:
TLDKNSCQDI | NECEEFGICP | QSCRNSKGSY | ECFCVDGFKS | MSTHYGERCA |
4100:
ADGSPPLLLL | PENVRIRKYN | ISSEKFSEYL | EEEEHIQAID | YDWDPEGIGL |
4150:
SVVYYTVLSQ | GSQFGAIKRA | YLPDFESGSN | NPVREVDLGL | KYLMQPDGLA |
4200:
VDWVGRHIYW | SDAKSQRIEV | ATLDGRYRKW | LITTQLDQPA | AIAVNPKLGL |
4250:
MFWTDQGKQP | KIESAWMNGE | HRSVLASANL | GWPNGLSIDY | LNGDRIYWSD |
4300:
SKEDVIESIK | YDGTDRRLII | NDAMKPFSLD | IFEDQLYWVA | KEKGEVWRQN |
4350:
KFGKGNKEKL | LVVNPWLTQV | RIFHQLRYNQ | SVSNPCKQVC | SHLCLLRPGG |
4400:
YSCACPQGSD | FVTGSTVECD | AASELPITMP | SPCRCMHGGS | CYFDENDLPK |
4450:
CKCSSGYSGE | YCEIGLSRGI | PPGTTMALLL | TFAMVIIVGA | LVLVGFFHYR |
4500:
KTGSLLPSLP | KLPSLSSLAK | PSENGNGVTF | RSGADVNMDI | GVSPFGPETI |
4550:
IDRSMAMNEQ | FVMEVGKQPV | IFENPMYAAK | DSTSKVGLAV | QGPSVSSQVT |
4600:
VPENVENQNY | GRSIDPSEIV | PEPKPASPGA | DETQGTKWNI | FKRKPKQTTN |
4650:
FENPIYAEMD | TEQKEAVAVA | PPPSPSLPAK | ASKRSSTPGY | TATEDTFKDT |
Vaild Sequence:
Related Databases
Uniprot: