Protein name:
Low-density lipoprotein receptor-related protein 2(LRP-2);
Alternative:
Megalin;Glycoprotein 330(gp330);
Organism:
Rat (Rattus norvegicus).
General Annotation
Sub Unit:
Binds plasminogen, extracellular matrix components, plasminogen activator-plasminogen activator inhibitor type I complex, apolipoprotein E-enriched beta-VLDL, lipoprotein lipase, lactoferrin, CLU/clusterin and calcium. Forms a multimeric complex together with a receptor-associated protein (RAP). Binds to ankyrin-repeat family A protein 2 (ANKRA2). Interacts with LRP2BP.
Function:
Acts together with cubilin to mediate HDL endocytosis (By similarity). Receptor-mediated uptake of polybasic drugs such as aprotinin, aminoglycosides and polymyxin B.
Subcellular Location:
Cell membrane
Single-pass type I membrane protein
Membrane
clathrin-coated pit
Cytoplasm
Expressed in clathrin-coated pits, a soluble form is possibly derived by cleavage at the cell surface.
Protein Attributes:
50:
MERGAAAAAW | MLLLAIAACL | EPVSSQECGS | GNFRCDNGYC | IPASWRCDGT |
100:
RDCLDDTDEI | GCPPRSCESG | LFLCPAEGTC | IPSSWVCDED | KDCSDGADEQ |
150:
QNCAGTTCSA | QQMTCSNGQC | IPSEYRCDHV | SDCPDGSDER | NCHYPTCDQL |
200:
TCANGACYNT | SQRCDQKVDC | RDSSDEANCT | TLCSQKEFEC | GSGECILRAY |
250:
VCDHDNDCED | NSDERNCNYD | TCGGHQFTCS | NGQCINQNWV | CDGDDDCQDS |
300:
GDEDGCESNQ | SHHRCYPREW | ACPGSGRCIS | IDKVCDGVPD | CPEGDDENNV |
350:
TSGRTCGMGV | CSVLNCEYQC | HQTPFGGECF | CPPGHIINSN | DSRTCIDFDD |
400:
CQIWGICDQK | CENRQGRHQC | LCEEGYILER | GQHCKSSDSF | SAASVIFSNG |
450:
RDLLVGDLHG | RNFRILAESK | NRGMVMGVDF | HYQKHRVFWT | DPMQEKVFST |
500:
DINGLNTQEI | LNVSVDTPEN | LAVDWINNKL | YLVETKVNRI | DVVNLEGNQR |
550:
VTLITENLGH | PRGIALDPTV | GYLFFSDWGS | LSGQPKVERA | FMDGSNRKDL |
600:
VTTKVGWPAG | ITLDLVSKRV | YWVDSRYDYI | ETVTYDGIQR | KTVARGGSLV |
650:
PHPFGISLFE | EHVFFTDWTK | MAVMKASKFT | ETNPQVYHQS | SLRPHGVTVY |
700:
HALRQPNATN | PCGSNNGGCA | QVCVLSHRTD | NGGLGYRCKC | EFGFELDDDE |
750:
HRCVAVKNFL | LFSSKTAVRG | IPFTLSTQED | VMVPVTGSPS | FFVGIDFDAQ |
800:
HSTVFYSDLS | KDIIYKQKID | GTGKEVITAN | RLESVECLTF | DWISRNLYWT |
850:
DGGLKSVTVL | RLADKSRRQI | ISNLNNPRSI | VVHPTAGYMF | LSDWFRPAKI |
900:
MRAWSDGSHL | MPIVNTSLGW | PNGLAIDWSA | SRLYWVDAFF | DKIEHSTLDG |
950:
LDRKRLGHVD | QMTHPFGLTV | FKDNVFITDW | RLGAIIRVRK | SDGGDMTVIR |
1000:
RGISSVMHVK | AYDADLQTGS | NYCSQTTHAN | GDCSHFCFPV | PNFQRVCGCP |
1050:
YGMKLQRDQM | TCEGDPAREP | PTQQCGSLSF | PCNNGKCVPS | FFRCDGVDDC |
1100:
HDNSDEHQCG | VFNNTCSPSA | FACVRGGQCI | PGQWHCDRQN | DCLDGSDEQN |
1150:
CPTHATSSTC | PSTSFTCDNH | VCIPKDWVCD | TDNDCSDGSD | EKNCQASGTC |
1200:
QPTQFRCPDH | RCISPLYVCD | GDKDCADGSD | EAGCVLNCTS | AQFKCADGSS |
1250:
CINSRYRCDG | VYDCRDNSDE | AGCPTRPPGM | CHPDEFQCQG | DGTCIPNTWE |
1300:
CDGHPDCIHG | SDEHTGCVPK | TCSPTHFLCD | NGNCIYKAWI | CDGDNDCRDM |
1350:
SDEKDCPTQP | FHCPSTQWQC | PGYSTCINLS | ALCDGVFDCP | NGTDESPLCN |
1400:
QDSCSHFNGG | CTHQCMQGPF | GATCLCPLGY | QLANDTKTCE | DINECDIPGF |
1450:
CSQHCVNMRG | SFRCACDPEY | TLESDGRTCK | VTGSENPLLV | VASRDKIIVD |
1500:
NITAHTHNLY | SLVQDVSFVV | ALDFDSVTGR | VFWSDLLQGK | TWSVFQNGTD |
1550:
KRVVHDSGLS | VTEMIAVDWI | GRNLYWTDYA | LETIEVSKID | GSHRTVLISK |
1600:
NVTKPRGLAL | DPRMGDNVMF | WSDWGHHPRI | ERASMDGTMR | TVIVQEKIYW |
1650:
PCGLSIDYPN | RLIYFMDAYL | DYIEFCDYDG | HNRRQVIASD | LVLHHPHALT |
1700:
LFEDFVYWTD | RGTRQVMQAN | KWHGGNQSVV | MYSVHQPLGI | TAIHPSRQPP |
1750:
SRNPCASASC | SHLCLLSAQA | PRHYSCACPS | GWNLSDDSVN | CVRGDQPFLM |
1800:
SVRDNIIFGI | SLDPEVKSND | AMVPISGIQH | GYDVEFDDSE | QFIYWVENPG |
1850:
EIHRVKTDGS | NRTVFAPLSL | LGSSLGLALD | WVSRNIYYTT | PASRSIEVLT |
1900:
LKGDTRYGKT | LIANDGTPLG | VGFPVGIAVD | PARGKLYWSD | HGTDSGVPAK |
1950:
IASANMDGTS | LKILFTGNLQ | HLEVVTLDIQ | EQKLYWAVTS | RGVIERGNVD |
2000:
GTERMILVHH | LAHPWGLVVY | GSFLYYSDEQ | YEVIERVDKS | SGNNKVVLRD |
2050:
NVPYLRGLRV | YHRRNAADSS | NGCSNNPNAC | QQICLPVPGG | MFSCACASGF |
2100:
KLSPDGRSCS | PYNSFMVVSM | LPAVRGFSLE | LSDHSEAMVP | VAGQGRNVLH |
2150:
ADVDVANGFI | YWCDFSSSVR | SSNGIRRIKP | DGSNFTNVVT | YGIGANGIRG |
2200:
VALDWAAGNL | YFTNAFVYET | LIEVLRINTT | YRRVLLKVSV | DMPRHIIVDP |
2250:
KHRYLFWADY | GQKPKIERSF | LDCTNRTVLV | SEGIVTPRGL | AMDHDTGYIY |
2300:
WVDDSLDLIA | RIHLDGGESQ | VVRYGSRYPT | PYGITVFGES | IIWVDRNLKK |
2350:
VFQASKQPGN | TDPPVVIRDK | INLLRDVTIF | DEHAQPLSPA | ELNNNPCLQS |
2400:
NGGCSHFCFA | LPELPTPRCG | CAFGTLGNDG | KSCATSQEDF | LIYSLNNSLR |
2450:
SLHFDPRDHS | LPFQVISVAG | TAIALDYDRR | NNRIFFTQKL | NSLRGQISYV |
2500:
SLYSGSSSPT | VLLSNIGVTD | GIAFDWINRR | IYYSDFSNQT | INSMAEDGSN |
2550:
RAVIARVSKP | RAIVLDPCRG | YMYWTDWGTN | AKIERATLGG | NFRVPIVNTS |
2600:
LVWPNGLALD | LETDLLYWAD | ASLQKIERST | LTGTNREVVV | STAFHSFGLT |
2650:
VYGQYIYWTD | LYTRKIYRAN | KYDGSDLVAM | TTRLPTQPSG | ISTVVKTQRQ |
2700:
QCSNPCDQFN | GGCSHICAPG | PNGAECQCPH | EGNWYLANDN | KYCVVDTGTR |
2750:
CNQLQFTCLN | GHCINQDWKC | DNDNDCGDGS | DELPTVCAFH | TCRSTAFTCG |
2800:
NGRCVPYHYR | CDYYNDCGDN | SDEAGCLFRN | CNSTTEFTCS | NGRCIPLSYV |
2850:
CNGINNCHDN | DTSDEKNCPP | HTCPPDFTKC | QTTNICVPRA | FLCDGDNDCG |
2900:
DGSDENPIYC | ASHTCRSNEF | QCLSPQRCIP | SYWFCDGEAD | CADGSDEPDT |
2950:
CGHSVNTCRA | SQFQCDNGRC | ISGNWVCDGD | NDCGDMSDED | QRHHCELQNC |
3000:
SSTQFTCVNS | RPPNRRCIPQ | YWVCDGDADC | SDALDELQNC | TMRTCSAGEF |
3050:
SCANGRCVRQ | SFRCDRRNDC | GDYSDERGCS | YPPCHANQFT | CQNGRCIPRF |
3100:
FVCDEDNDCG | DGSDEQEHLC | HTPEPTCPLH | QFRCDNGHCI | EMGRVCNHVD |
3150:
DCSDNSDEKG | CGINECLDSS | ISRCDHNCTD | TITSFYCSCL | PGYKLMSDKR |
3200:
SCVDIDECKE | SPQLCSQKCE | NVVGSYICKC | APGYIREPDG | KSCRQNSNIE |
3250:
PYLIFSNRYY | IRNLTTDGSS | YSLILQGLGN | VVALDFDRVE | KRLYWIDAEK |
3300:
QIIERMFLNK | TNRETIINHR | LRRAESLAVD | WVSRKLYWLD | AILDCLFVSD |
3350:
LEGRHRKMIA | QHCVDANNTF | CFEHPRGIVL | HPQRGHVYWA | DWGVHAYIGR |
3400:
IGMDGTNKSV | IISTKIEWPN | AITIDYTNDL | LYWADAHLGY | IEFSDLEGHH |
3450:
RHTVYDGSLP | HPFALTIFED | TVFWTDWNTR | TVEKGNKYDG | SGRVVLVNTT |
3500:
HKPFDIHVYH | PYRQPIMSNP | CGTNNGGCSH | LCLIKAGGRG | FTCACPDDFQ |
3550:
TVQLRDRTLC | MPMCSSTQFL | CGNNEKCIPI | WWKCDGQKDC | SDGSDEPDLC |
3600:
PHRFCRLGQF | QCRDGNCTSP | QALCNARQDC | ADGSDEDRVL | CEHHRCESNE |
3650:
WQCANKRCIP | QSWQCDSVND | CLDNSDEDTS | HCASRTCRPG | QFKCNNGRCI |
3700:
PQSWKCDVDN | DCGDYSDEPI | DECTTAAYNC | DNHTEFSCKT | NYRCIPQWAV |
3750:
CNGFDDCRDN | SDEQGCESVP | CHPSGDFRCA | NHHCIPLRWK | CDGTDDCGDN |
3800:
SDEENCVPRE | CSESEFRCAD | QQCIPSRWVC | DQENDCGDNS | DERDCEMKTC |
3850:
HPEHFQCTSG | HCVPKALACD | GRADCLDASD | ESACPTRFPN | GTYCPAAMFE |
3900:
CKNHVCIQSF | WICDGENDCV | DGSDEEIHLC | FNIPCESPQR | FRCDNSRCVY |
3950:
GHQLCNGVDD | CGDGSDEKEE | HCRKPTHKPC | TDTEYKCSNG | NCISQHYVCD |
4000:
NVNDCGDLSD | ETGCNLGDNR | TCAENICEQN | CTQLSSGGFI | CSCRPGFKPS |
4050:
TSDKNSCQDI | NECEEFGICP | QSCRNSKGSY | ECFCVDGFKS | MSTHYGERCA |
4100:
ADGSPPLLLL | PENVRIRKYN | TSSEKFSEYL | EEEEHIQTID | YDWDPEHIGL |
4150:
SVVYYTVLAQ | GSQFGAIKRA | YIPNFESGSN | NPIREVDLGL | KYLMQPDGLA |
4200:
VDWVGRHIYW | SDAKSQRIEV | ATLDGRYRKW | LITTQLDQPA | AIAVNPKLGL |
4250:
MFWTDQGKQP | KIESAWMNGE | HRSVLVSENL | GWPNGLSIDY | LNDDRVYWSD |
4300:
SKEDVIEAIK | YDGTDRRLII | NEAMKPFSLD | IFEDKLYWVA | KEKGEVWRQN |
4350:
KFGKENKEKV | LVVNPWLTQV | RIFHQLRYNQ | SVSNPCKQVC | SHLCLLRPGG |
4400:
YSCACPQGSD | FVTGSTVQCD | AASELPVTMP | PPCRCMHGGN | CYFDENELPK |
4450:
CKCSSGYSGE | YCEVGLSRGI | PPGTTMAVLL | TFVIVIIVGA | LVLVGLFHYR |
4500:
KTGSLLPTLP | KLPSLSSLAK | PSENGNGVTF | RSGADVNMDI | GVSPFGPETI |
4550:
IDRSMAMNEH | FVMEVGKQPV | IFENPMYAAK | DNTSKVALAV | QGPSTGAQVT |
4600:
VPENVENQNY | GRPIDPSEIV | PEPKPASPGA | DEIQGKKWNI | FKRKPKQTTN |
4650:
FENPIYAEMD | SEVKDAVAVA | PPPSPSLPAK | ASKRNLTPGY | TATEDTFKDT |
Vaild Sequence:
Related Databases
Uniprot: