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Index > Protein center > LRWD1(Gene name) > Mouse
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  • LRWD1 (Gene name),
  • Leucine-rich repeat and WD repeat-containing protein 1 (Protein name ),  LRWD1_MOUSE from NCBI database.
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  • General Annotation
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  • Gene name:
    LRWD1(Orca);
    Protein name:
    Leucine-rich repeat and WD repeat-containing protein 1;
    Alternative:
    Origin recognition complex-associated protein;ORC-associated protein(ORCA);
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Component of the ORC complex.
    Function:
    Associated component of the origin recognition complex (ORC) required to recruit and stabilize the ORC complex to chromatin. Probably required for the association of ORC on chromatin during G1 to establish pre-replication complex (preRC) and to heterochromatic sites in post-replicated cells. Binds a combination of DNA and histone methylation repressive marks on heterochromatin: binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3 in a cooperative manner with DNA methylation. It is unclear whether it recongnizes and binds these repressive marks by itself or needs additional factors.
    Subcellular Location:
    Nucleus Chromosome centromere Chromosome telomere Cytoplasm cytoskeleton centrosome Localizes to heterochromatin during G1 phase. Restricted to centromeres or telomeres as cells progress though S phase. When cells enter mitosis, relocalizes to centromeres.
    Protein Attributes:
    Sequence length:
    648
    Sequence:
    50:
    MAPLTPQLLL | QRGRPKTDKL | GKIQSLNLSG | LQLLSEHLDP | NLLGRLKKLR | 
    100:
    ELDLSNNLLE | TLPANLGLSH | LRILRCTNNQ | LGDVTALHQF | PELEELNLEG | 
    150:
    NPFLTVSDNL | KVSFLLPKLR | KVNGKDTAST | CSQVENLDRE | LMDRVTAHWQ | 
    200:
    KFIATVSPEE | ETDKVRADFM | RSAVRDVCYG | PESLIEFTQW | RVRMIAEELV | 
    250:
    ASGGAQVQDA | KVPVEHPQAA | GASKFRAREV | ASKRPGKDPV | TLPPSKRVRA | 
    300:
    LPPAQAEGSP | MGADGGQAAL | HLEPLHFLQC | HSRNNSPKDL | ETQLWACAFE | 
    350:
    PAREEGHSRA | TSQTVATCGG | EAVCVIDCQT | GLVLHKYKVP | GEEFFSVAWT | 
    400:
    ALTVVTQAGH | KKRWNMLAAA | GLRGMVRLLH | VRAGFCCSVI | RAHKKAIATL | 
    450:
    CFSPSHETHL | FTASYDKRII | LWDIGVPNQD | YKFQASQLLT | LNCGSVPLRL | 
    500:
    CPVATCPDDF | LLAGCEGGCY | CWDVRLDQPQ | KQRVCEVNFI | FSEDSKVSGQ | 
    550:
    RVDGLAFVNE | DVVASKGSGQ | GTIYLWSWSQ | TWAGRGRQSV | LPVVILVRLQ | 
    600:
    WSPTNLAYFS | LSTCPGKNLV | LCGDEEGSVW | IYDVEHLLKE | PPQATTLQPP | 
    648:
    TQILKWPQPT | ALGQPVTKTM | INTVVANAAF | TYLTALTDSN | IVSIWRRC
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    Pfam:
    KEGG:
    UniGene:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Leucine-rich repeat and WD repeat-containing protein 1
    ELISA Kit for Mouse Leucine-rich repeat and WD repeat-containing protein 1
    CLIA Kit for Mouse Leucine-rich repeat and WD repeat-containing protein 1
    CLIA Kit for Mouse Leucine-rich repeat and WD repeat-containing protein 1
    Polyclonal Antibody for Mouse Leucine-rich repeat and WD repeat-containing protein 1
    Polyclonal Antibody for Mouse Leucine-rich repeat and WD repeat-containing protein 1
    Monoclonal Antibody for Mouse Leucine-rich repeat and WD repeat-containing protein 1
    Monoclonal Antibody for Mouse Leucine-rich repeat and WD repeat-containing protein 1
    Protein for Mouse Leucine-rich repeat and WD repeat-containing protein 1
    Protein for Mouse Leucine-rich repeat and WD repeat-containing protein 1

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    Precision
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    Recovery
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    References
    1. 1.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: BALB/c.
      strain: C57BL/6J.
      strain: NOD.
      tissue: Eye.
      tissue: Lung.
      tissue: Thymus.
    2. 2.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
      strain: C57BL/6J.
    3. 3.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: FVB/N.
      tissue: Colon.
    4. 4.
      "Identification of ten novel genes involved in human spermatogenesis by microarray analysis of testicular tissue."
      Lin Y.H. , Lin Y.M. , Teng Y.N. , Hsieh T.Y. , Lin Y.S. , Kuo P.L.
      Fertil. Steril.86:1650-1658(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
    5. 5.
      "Expression of lrwd1 in mouse testis and its centrosomal localization."
      Teng Y.N. , Liao M.H. , Lin Y.B. , Kuo P.L. , Kuo T.Y.
      Int. J. Androl.33:832-840(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
    6. 6.
      "Leucine-rich repeat and WD repeat-containing protein 1 is recruited to pericentric heterochromatin by trimethylated lysine 9 of histone H3 and maintains heterochromatin silencing."
      Chan K.M. , Zhang Z.
      J. Biol. Chem.287:15024-15033(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
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