Protein name:
Leucine-rich repeat and WD repeat-containing protein 1 ;
Alternative:
Origin recognition complex-associated protein ;ORC-associated protein (ORCA) ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Component of the ORC complex.
Function:
Associated component of the origin recognition complex (ORC) required to recruit and stabilize the ORC complex to chromatin. Probably required for the association of ORC on chromatin during G1 to establish pre-replication complex (preRC) and to heterochromatic sites in post-replicated cells. Binds a combination of DNA and histone methylation repressive marks on heterochromatin: binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3 in a cooperative manner with DNA methylation. It is unclear whether it recongnizes and binds these repressive marks by itself or needs additional factors.
Subcellular Location:
Nucleus
Chromosome
centromere
Chromosome
telomere
Cytoplasm
cytoskeleton
centrosome
Localizes to heterochromatin during G1 phase. Restricted to centromeres or telomeres as cells progress though S phase. When cells enter mitosis, relocalizes to centromeres.
Protein Attributes:
50:
MAPLTPQLLL | QRGRPKTDKL | GKIQSLNLSG | LQLLSEHLDP | NLLGRLKKLR |
100:
ELDLSNNLLE | TLPANLGLSH | LRILRCTNNQ | LGDVTALHQF | PELEELNLEG |
150:
NPFLTVSDNL | KVSFLLPKLR | KVNGKDTAST | CSQVENLDRE | LMDRVTAHWQ |
200:
KFIATVSPEE | ETDKVRADFM | RSAVRDVCYG | PESLIEFTQW | RVRMIAEELV |
250:
ASGGAQVQDA | KVPVEHPQAA | GASKFRAREV | ASKRPGKDPV | TLPPSKRVRA |
300:
LPPAQAEGSP | MGADGGQAAL | HLEPLHFLQC | HSRNNSPKDL | ETQLWACAFE |
350:
PAREEGHSRA | TSQTVATCGG | EAVCVIDCQT | GLVLHKYKVP | GEEFFSVAWT |
400:
ALTVVTQAGH | KKRWNMLAAA | GLRGMVRLLH | VRAGFCCSVI | RAHKKAIATL |
450:
CFSPSHETHL | FTASYDKRII | LWDIGVPNQD | YKFQASQLLT | LNCGSVPLRL |
500:
CPVATCPDDF | LLAGCEGGCY | CWDVRLDQPQ | KQRVCEVNFI | FSEDSKVSGQ |
550:
RVDGLAFVNE | DVVASKGSGQ | GTIYLWSWSQ | TWAGRGRQSV | LPVVILVRLQ |
600:
WSPTNLAYFS | LSTCPGKNLV | LCGDEEGSVW | IYDVEHLLKE | PPQATTLQPP |
648:
TQILKWPQPT | ALGQPVTKTM | INTVVANAAF | TYLTALTDSN | IVSIWRRC
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
ELISA Kit for Mouse Leucine-rich repeat and WD repeat-containing protein 1
ELISA Kit for Mouse Leucine-rich repeat and WD repeat-containing protein 1
CLIA Kit for Mouse Leucine-rich repeat and WD repeat-containing protein 1
CLIA Kit for Mouse Leucine-rich repeat and WD repeat-containing protein 1
Polyclonal Antibody for Mouse Leucine-rich repeat and WD repeat-containing protein 1
Polyclonal Antibody for Mouse Leucine-rich repeat and WD repeat-containing protein 1
Monoclonal Antibody for Mouse Leucine-rich repeat and WD repeat-containing protein 1
Monoclonal Antibody for Mouse Leucine-rich repeat and WD repeat-containing protein 1
Protein for Mouse Leucine-rich repeat and WD repeat-containing protein 1
Protein for Mouse Leucine-rich repeat and WD repeat-containing protein 1
R&D Technical Data
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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
Precision
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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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Recovery
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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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Linearity
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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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more...
Science309:1559-1563(2005)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain :
BALB/c .
strain :
C57BL/6J .
strain :
NOD .
tissue :
Eye .
tissue :
Lung .
tissue :
Thymus .
2.
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more...
PLoS Biol.7:E1000112-E1000112(2009)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain :
C57BL/6J .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain :
FVB/N .
tissue :
Colon .
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : TISSUE SPECIFICITY
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SUBCELLULAR LOCATION
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION