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Index > Protein center > Ltbp4(Gene name) > Mouse
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  • Ltbp4 (Gene name),
  • Latent-transforming growth factor beta-binding protein 4 (Protein name ),  LTBP4_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    Ltbp4;
    Protein name:
    Latent-transforming growth factor beta-binding protein 4(LTBP-4);
    Alternative:

    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Forms part of the large latent transforming growth factor beta precursor complex; removal is essential for activation of complex. Interacts with LTBP1 AND TGFB1. Binds to FBN1.
    Function:
    May be involved in the assembly, secretion and targeting of TGFB1 to sites at which it is stored and/or activated. May play critical roles in controlling and directing the activity of TGFB1. May have a structural role in the extra cellular matrix (ECM).
    Subcellular Location:
    Secreted extracellular space extracellular matrix
    Protein Attributes:
    Sequence length:
    1666
    Sequence:
    50:
    MRRPGLGGPC | PLLLLLLLPA | ATSASGSSPS | PSPSPIEKAV | VPSHQAGVAA | 
    100:
    CHCCLDQTPK | SSRCTRASCR | VRNCPPAKCT | GLEGCLTPTP | SVPSPSRSPV | 
    150:
    EKSQVSLNWQ | PLTLQEARAL | LRQRRPRGPW | ARALLKRRPP | HRAPAGQARV | 
    200:
    LCPLICHNGG | VCVKPDRCLC | PPDFAGKFCQ | LHSSGARPPA | PAMPGLTRSV | 
    250:
    YTMPLANHRD | DEHGVASMVS | VHVEHPQEAS | VVVHQVERVS | GPWEEANPEA | 
    300:
    LARAEAAARA | EAAAPYTVLA | QSAPREDGYS | DASGFGYCFR | ELRGSECASP | 
    350:
    LPGLRTQEVC | CRGEGLAWGV | HDCHPCAEHL | RNSNQVSGPN | GPCPPGFERV | 
    400:
    NGSCVDVDEC | ATGGRCQHGE | CANTRGGYTC | VCPDGFLLDS | SRSSCISQHV | 
    450:
    ISEAKGPCYR | VLHDGGCSLP | ILRNITKQIC | CCSRVGKAWG | RGCQLCPPYG | 
    500:
    SEGFREICPA | GPGYHYSASD | LRYNTRPLNQ | DPPRVTFNQP | RVPPATPRPP | 
    550:
    TGFLPTRRPE | PRPDPGPQPE | PRPRPEPRPR | PESRPRPEPR | PRPEPRPQPE | 
    600:
    SQPRPESRPR | PESQPWPEFP | LPSIPAWTGP | EIPESGPSSS | MCQRNPQVCG | 
    650:
    PGRCVPRPSG | YTCACDPGFR | LGPQGTRCID | IDECRRVPTP | CAPGRCENTP | 
    700:
    GSFRCVCGTG | FQAGPRATEC | LDVDECRRVP | PPCDRGRCEN | TPGSFLCVCP | 
    750:
    AGYQAAPHGA | SCQDVDECTQ | SPGLCGRGVC | ENLPGSFRCV | CPAGFRGSAC | 
    800:
    EEDVDECAQQ | PPPCGPGRCD | NTAGSFHCAC | PAGFRSRGPG | APCQDVDECS | 
    850:
    RSPSPCAYGR | CENTEGSFKC | VCPTGFQPNA | AGSECEDVDE | CENRLACPGQ | 
    900:
    ECVNSPGSFQ | CRACPVGHHL | HRGRCTDVDE | CSSGTPCGLH | GQCTNTKGSF | 
    950:
    HCSCSTGYRA | PSGQPGPCAD | INECLEGDFC | FPHGECLNTD | GSFTCTCAPG | 
    1000:
    YRPGPRGASC | LDVDECSEED | LCQSGICTNT | DGSFECICPP | GHRAGPDLAS | 
    1050:
    CLDIDECRER | GPALCGSQRC | ENSPGSYRCV | RDCDPGYHPG | PEGTCDDIDE | 
    1100:
    CREYGSAICG | AQRCENTPGS | YRCTPACDPG | YQPTPGGGCQ | DVDECRNRSF | 
    1150:
    CGAHAMCQNL | PGSFQCVCDQ | GYEGARDGRH | CVDVNECETL | QGVCGSALCE | 
    1200:
    NVEGSFLCVC | PNSPEEFDPM | TGRCVPPRAP | AGTFPGSQPQ | APASPSLPAR | 
    1250:
    PPAPPPPRRP | SPPRQGPVSS | GRRECYFDTA | APDACDNILA | RNVTWQECCC | 
    1300:
    TVGEGWGSGC | RIQQCPGTET | AEYQSLCPHG | RGYLVPSGDL | SARRDVDECQ | 
    1350:
    LFQDQVCKSG | VCVNTAPGYS | CYCSNGFYYH | AHRLECVDND | ECADEEPACE | 
    1400:
    GGRCVNTVGS | YHCTCEPPLV | LDGSRRRCVS | NESQSLDDNL | GVCWQEVGPD | 
    1450:
    LVCSRPRLDR | QATYTECCCL | YGEAWGMDCA | LCPAQDSDDF | EALCNVLRPP | 
    1500:
    AYGPPRPGGF | GIPYEYGPDI | GPPYQSLPYG | PDLYPPPVLP | YDPYPPPPGP | 
    1550:
    FARREAPYGA | PPFDMPDFED | DGGPYGESET | PDPPSRGTGW | PYRSRDTRGS | 
    1600:
    FPEPEESSER | GSYTGALSEP | YEGLEAEECG | ILDGCPHGRC | VRVPEGFTCD | 
    1650:
    CFDGYRLDIT | RMSCVDVNEC | DEAEATSPLC | VNARCVNTDG | SFRCICRPGF | 
    1666:
    APTHQPHHCA | PARPRA
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    Pfam:
    String:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse LTBP-4
    Cat.:
    E11075h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Mouse LTBP-4
    Cat.:
    E11075m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse LTBP-4
    Cat.:
    U11075h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse LTBP-4
    Cat.:
    U11075m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Mouse LTBP-4
    Cat.:
    P11075Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse LTBP-4
    Monoclonal Antibody for Mouse LTBP-4
    Monoclonal Antibody for Mouse LTBP-4
    Protein for Mouse LTBP-4
    Protein for Mouse LTBP-4

    R&D Technical Data
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Precision
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    Recovery
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    References
    1. 1.
      "Disruption of the gene encoding the latent transforming growth factor-beta binding protein 4 (LTBP-4) causes abnormal lung development, cardiomyopathy, and colorectal cancer."
      Sterner-Kock A. , Thorey I.S. , Koli K. , Wempe F. , Otte J. , Bangsow T. , Kuhlmeier K. , Kirchner T. , Jin S. , Keski-Oja J. , von Melchner H.
      Genes Dev.16:2264-2273(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2);DISRUPTION PHENOTYPE
    2. 2.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
      strain: C57BL/6J.
    3. 3.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 60-1666 (ISOFORM 3)
      strain: C57BL/6.
      tissue: Brain.
    4. 4.
      "Mutations in LTBP4 cause a syndrome of impaired pulmonary, gastrointestinal, genitourinary, musculoskeletal, and dermal development."
      Urban Z. , Hucthagowder V. , Schuermann N. , Todorovic V. , Zilberberg L. , Choi J. , Sens C. , Brown C.W. , Clark R.D. , Holland K.E. , Marble M. , Sakai L.Y. , Dabovic B. , Rifkin D.B. , Davis E.C.
      Am. J. Hum. Genet.85:593-605(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE
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