LAMTOR5 ELISA Kit for Human(Homo sapiens) | EIAab.comLAMTOR5 ELISA Kit for Human(Homo sapiens)

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LAMTOR5 (Gene name),

Ragulator complex protein LAMTOR5 (Protein name ), LTOR5_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

LAMTOR5(HBXIP;XIP);

Protein name:

Ragulator complex protein LAMTOR5;

Alternative:

Late endosomal/lysosomal adaptor and MAPK and MTOR activator 5;Hepatitis B virus X-interacting protein(HBV X-interacting protein);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Homodimer (Probable). Part of the Ragulator complex composed of LAMTOR1, LAMTOR2, LAMTOR3, LAMTOR4 and LAMTOR5. LAMTOR4 and LAMTOR5 form a heterodimer that interacts, through LAMTOR1, with a LAMTOR2, LAMTOR3 heterodimer. The Ragulator complex interacts with both the mTORC1 complex and heterodimers constituted of the Rag GTPases RRAGA, RRAGB, RRAGC and RRAGD; regulated by amino acid availability. Interacts with phosphorylated BIRC5; the resulting complex binds pro-caspase-9, as well as active caspase-9, but much less efficiently. Interacts with SUPV3L1. Interacts with hepatitis B virus (HBV) oncoprotein HBX C-terminus.

Function:

As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. When complexed to BIRC5, interferes with apoptosome assembly, preventing recruitment of pro-caspase-9 to oligomerized APAF1, thereby selectively suppressing apoptosis initiated via the mitochondrial/cytochrome c pathway. Down-regulates hepatitis B virus (HBV) replication.

Subcellular Location:

Cytoplasm Lysosome

Protein Attributes:

Sequence length:

Sequence:

50:

91:

QAAKLTSDPT | DIPVVCLESD | NGNIMIQKHD | GITVAVHKMA | S

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

O43504

KEGG:

hsa:10542

UniGene:

Hs.439815

STRING:

9606.ENSP00000256644

MIM:

608521

Uniprot:

O43504

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ELISA Kit for Human Ragulator complex protein LAMTOR5

Cat.:

E1313h

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Packing:

96T

ELISA Kit for Human Ragulator complex protein LAMTOR5

Cat.:

E1313b

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96T

ELISA Kit for Human Ragulator complex protein LAMTOR5

Cat.:

E1313m

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96T

ELISA Kit for Human Ragulator complex protein LAMTOR5

Cat.:

E1313p

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Packing:

96T

CLIA Kit for Human Ragulator complex protein LAMTOR5

Cat.:

U1313b

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MSDS:

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Packing:

96T

CLIA Kit for Human Ragulator complex protein LAMTOR5

Cat.:

U1313h

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MSDS:

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Packing:

96T

CLIA Kit for Human Ragulator complex protein LAMTOR5

Cat.:

U1313p

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MSDS:

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Packing:

96T

CLIA Kit for Human Ragulator complex protein LAMTOR5

Cat.:

U1313m

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MSDS:

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Packing:

96T

Polyclonal Antibody for Human Ragulator complex protein LAMTOR5

Cat.:

P1313Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Ragulator complex protein LAMTOR5

Cat.:

P1313Rb-h

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Ragulator complex protein LAMTOR5

Monoclonal Antibody for Human Ragulator complex protein LAMTOR5

Protein for Human Ragulator complex protein LAMTOR5

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

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References

1.

"Cloning and characterization of a novel hepatitis B virus x binding protein that inhibits viral replication."
Melegari M. , Scaglioni P.P. , Wands J.R.
J. Virol.72:1737-1743(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];MUTAGENESIS
tissue: Liver.
2.

"Clone of human uterus hepatitis B virus x interacting protein (HBXIP) gene."
Zhang X. , Ye L. , Shi Z.
Submitted (2004-05) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Uterus.
3.

"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L. , Schick M. , Neubert P. , Schatten R. , Henze S. , Korn B.
Submitted (2004-06) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
4.

"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Halleck A. , Ebert L. , Mkoundinya M. , Schick M. , Eisenstein S. , Neubert P. , Kstrang K. , Schatten R. , Shen B. , Henze S. , Mar W. , Korn B. , Zuo D. , Hu Y. , LaBaer J.
Submitted (2004-06) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
5.

"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G. , Barlow K.F. , McLay K.E. , Kaul R. , Swarbreck D. , Dunham A. , Scott C.E. , Howe K.L. , Woodfine K. , Spencer C.C.A. , Jones M.C. , Gillson C. , Searle S. , Zhou Y. , Kokocinski F. , McDonald L. , Evans R. , Phillips K. , more...
Nature441:315-321(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Colon.
7.

Bienvenut W.V. , Quadroni M.
Submitted (2005-07) to the UniProtKB

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 1-14;ACETYLATION AT MET-1;IDENTIFICATION BY MASS SPECTROMETRY
tissue: Melanoma.
8.

"HBXIP functions as a cofactor of survivin in apoptosis suppression."
Marusawa H. , Matsuzawa S. , Welsh K. , Zou H. , Armstrong R. , Tamm I. , Reed J.C.
EMBO J.22:2729-2740(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN APOPTOSIS SUPPRESSION;INTERACTION WITH BIRC5;SUBCELLULAR LOCATION
9.

"Human ATP-dependent RNA/DNA helicase hSuv3p interacts with the cofactor of survivin HBXIP."
Minczuk M. , Mroczek S. , Pawlak S.D. , Stepien P.P.
FEBS J.272:5008-5019(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SUPV3L1;SUBCELLULAR LOCATION
10.

"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."
Matsuoka S. , Ballif B.A. , Smogorzewska A. , McDonald E.R. III , Hurov K.E. , Luo J. , Bakalarski C.E. , Zhao Z. , Solimini N. , Lerenthal Y. , Shiloh Y. , Gygi S.P. , Elledge S.J.
Science316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Embryonic kidney.
11.

"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
12.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
13.

"Ragulator is a GEF for the Rag GTPases that signal amino acid levels to mTORC1."
Bar-Peled L. , Schweitzer L.D. , Zoncu R. , Sabatini D.M.
Cell150:1196-1208(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN MTORC1 SIGNALING;IDENTIFICATION IN RAGULATOR COMPLEX;INTERACTION WITH MTORC1 COMPLEX AND RAG GTPASES;SUBCELLULAR LOCATION
14.

"Structural characterization of HBXIP: the protein that interacts with the anti-apoptotic protein survivin and the oncogenic viral protein HBx."
Garcia-Saez I. , Lacroix F.B. , Blot D. , Gabel F. , Skoufias D.A.
J. Mol. Biol.405:331-340(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.51 ANGSTROMS);SUBUNIT

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