Protein name:
Mitogen-activated protein kinase kinase kinase 12 ;
Alternative:
Leucine-zipper protein kinase (ZPK) ;Dual leucine zipper bearing kinase (DLK) ;Mixed lineage kinase ;MAPK-upstream kinase (MUK) ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts with MBIP.
Function:
May be an activator of the JNK/SAPK pathway. Phosphorylates beta-casein, histone 1 and myelin basic protein in vitro.
Subcellular Location:
Cytoplasm
Membrane
Peripheral membrane protein
Protein Attributes:
50:
MACLHETRTP | SPSFGGFVST | LSEASMRKLD | PDTSDCTPEK | DLTPTHVLQL |
100:
HEQDAGGPGG | AAGSPESRAS | RVRADEVRLQ | CQSGSGFLEG | LFGCLRPVWT |
150:
MIGKAYSTEH | KQQQEDLWEV | PFEEILDLQW | VGSGAQGAVF | LGRFHGEEVA |
200:
VKKVRDLKET | DIKHLRKLKH | PNIITFKGVC | TQAPCYCILM | EFCAQGQLYE |
250:
VLRAGRPVTP | SLLVDWSMGI | AGGMNYLHLH | KIIHRDLKSP | NMLITYDDVV |
300:
KISDFGTSKE | LSDKSTKMSF | AGTVAWMAPE | VIRNEPVSEK | VDIWSFGVVL |
350:
WELLTGEIPY | KDVDSSAIIW | GVGSNSLHLP | VPSSCPDGFK | ILLRQCWNSK |
400:
PRNRPSFRQI | LLHLDIASAD | VLSTPQETYF | KSQAEWREEV | KLHFEKIKSE |
450:
GTCLHRLEEE | LVMRRREELR | HALDIREHYE | RKLERANNLY | MELNALMLQL |
500:
ELKERELLRR | EQALERRCPG | LLKPHPSRGL | LHGNTMEKLI | KKRNVPQKLS |
550:
PHSKRPDILK | TESLLPKLDA | ALSGVGLPGC | PKGPPSPGRS | RRGKTRHRKA |
600:
SAKGSCGDLP | GLRTAVPPHE | PGGPGSPGGL | GGGPSAWEAC | PPALRGLHHD |
650:
LLLRKMSSSS | PDLLSAALGS | RGRGATGGAG | DPGSPPPARG | DTPPSEGSAP |
700:
GSTSPDSPGG | AKGEPPPPVG | PGEGVGLLGT | GREGTSGRGG | SRAGSQHLTP |
750:
AALLYRAAVT | RSQKRGISSE | EEEGEVDSEV | ELTSSQRWPQ | SLNMRQSLST |
800:
FSSENPSDGE | EGTASEPSPS | GTPEVGSTNT | DERPDERSDD | MCSQGSEIPL |
850:
DPPPSEVIPG | PEPSSLPIPH | QELLRERGPP | NSEDSDCDST | ELDNSNSVDA |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Rat
Mouse
ELISA Kit for Human Mitogen-activated protein kinase kinase kinase 12
ELISA Kit for Human Mitogen-activated protein kinase kinase kinase 12
ELISA Kit for Human Mitogen-activated protein kinase kinase kinase 12
CLIA Kit for Human Mitogen-activated protein kinase kinase kinase 12
CLIA Kit for Human Mitogen-activated protein kinase kinase kinase 12
CLIA Kit for Human Mitogen-activated protein kinase kinase kinase 12
Polyclonal Antibody for Human Mitogen-activated protein kinase kinase kinase 12
Polyclonal Antibody for Human Mitogen-activated protein kinase kinase kinase 12
Polyclonal Antibody for Human Mitogen-activated protein kinase kinase kinase 12
Monoclonal Antibody for Human Mitogen-activated protein kinase kinase kinase 12
Monoclonal Antibody for Human Mitogen-activated protein kinase kinase kinase 12
Monoclonal Antibody for Human Mitogen-activated protein kinase kinase kinase 12
Protein for Human Mitogen-activated protein kinase kinase kinase 12
Protein for Human Mitogen-activated protein kinase kinase kinase 12
Protein for Human Mitogen-activated protein kinase kinase kinase 12
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
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Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue :
Teratocarcinoma .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA]
3.
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T.
,
Suzuki Y.
,
Nishikawa T.
,
Otsuki T.
,
Sugiyama T.
,
Irie R.
,
Wakamatsu A.
,
Hayashi K.
,
Sato H.
,
Nagai K.
,
Kimura K.
,
Makita H.
,
Sekine M.
,
Obayashi M.
,
Nishi T.
,
Shibahara T.
,
Tanaka T.
,
Ishii S.
,
Yamamoto J.
,
Saito K.
,
Kawai Y.
,
Isono Y.
,
Nakamura Y.
,
Nagahari K.
,
Murakami K.
,
Yasuda T.
,
Iwayanagi T.
,
Wagatsuma M.
,
Shiratori A.
,
Sudo H.
,
Hosoiri T.
,
Kaku Y.
,
Kodaira H.
,
Kondo H.
,
Sugawara M.
,
Takahashi M.
,
Kanda K.
,
Yokoi T.
,
Furuya T.
,
Kikkawa E.
,
Omura Y.
,
Abe K.
,
Kamihara K.
,
Katsuta N.
,
Sato K.
,
Tanikawa M.
,
Yamazaki M.
,
Ninomiya K.
,
Ishibashi T.
,
Yamashita H.
,
Murakawa K.
,
Fujimori K.
,
Tanai H.
,
Kimata M.
,
Watanabe M.
,
Hiraoka S.
,
Chiba Y.
,
Ishida S.
,
Ono Y.
,
Takiguchi S.
,
Watanabe S.
,
Yosida M.
,
Hotuta T.
,
Kusano J.
,
Kanehori K.
,
Takahashi-Fujii A.
,
Hara H.
,
Tanase T.-O.
,
Nomura Y.
,
Togiya S.
,
Komai F.
,
Hara R.
,
Takeuchi K.
,
Arita M.
,
Imose N.
,
Musashino K.
,
Yuuki H.
,
Oshima A.
,
Sasaki N.
,
Aotsuka S.
,
Yoshikawa Y.
,
Matsunawa H.
,
Ichihara T.
,
Shiohata N.
,
Sano S.
,
Moriya S.
,
Momiyama H.
,
Satoh N.
,
Takami S.
,
Terashima Y.
,
Suzuki O.
,
Nakagawa S.
,
Senoh A.
,
Mizoguchi H.
,
Goto Y.
,
Shimizu F.
,
Wakebe H.
,
Hishigaki H.
,
Watanabe T.
,
Sugiyama A.
,
Takemoto M.
,
Kawakami B.
,
Yamazaki M.
,
Watanabe K.
,
Kumagai A.
,
Itakura S.
,
Fukuzumi Y.
,
Fujimori Y.
,
Komiyama M.
,
Tashiro H.
,
Tanigami A.
,
Fujiwara T.
,
Ono T.
,
Yamada K.
,
Fujii Y.
,
Ozaki K.
,
Hirao M.
,
Ohmori Y.
,
Kawabata A.
,
Hikiji T.
,
Kobatake N.
,
Inagaki H.
,
Ikema Y.
,
Okamoto S.
,
Okitani R.
,
Kawakami T.
,
Noguchi S.
,
Itoh T.
,
Shigeta K.
,
Senba T.
,
Matsumura K.
,
Nakajima Y.
,
Mizuno T.
,
Morinaga M.
,
Sasaki M.
,
Togashi T.
,
Oyama M.
,
Hata H.
,
Watanabe M.
,
Komatsu T.
,
Mizushima-Sugano J.
,
Satoh T.
,
Shirai Y.
,
Takahashi Y.
,
Nakagawa K.
,
Okumura K.
,
Nagase T.
,
Nomura N.
,
Kikuchi H.
,
Masuho Y.
,
Yamashita R.
,
Nakai K.
,
Yada T.
,
Nakamura Y.
,
Ohara O.
,
Isogai T.
,
Sugano S.
more...
Nat. Genet.36:40-45(2004)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
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Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
4.
"The finished DNA sequence of human chromosome 12."
Scherer S.E.
,
Muzny D.M.
,
Buhay C.J.
,
Chen R.
,
Cree A.
,
Ding Y.
,
Dugan-Rocha S.
,
Gill R.
,
Gunaratne P.
,
Harris R.A.
,
Hawes A.C.
,
Hernandez J.
,
Hodgson A.V.
,
Hume J.
,
Jackson A.
,
Khan Z.M.
,
Kovar-Smith C.
,
Lewis L.R.
,
Lozado R.J.
,
Metzker M.L.
,
Milosavljevic A.
,
Miner G.R.
,
Montgomery K.T.
,
Morgan M.B.
,
Nazareth L.V.
,
Scott G.
,
Sodergren E.
,
Song X.-Z.
,
Steffen D.
,
Lovering R.C.
,
Wheeler D.A.
,
Worley K.C.
,
Yuan Y.
,
Zhang Z.
,
Adams C.Q.
,
Ansari-Lari M.A.
,
Ayele M.
,
Brown M.J.
,
Chen G.
,
Chen Z.
,
Clerc-Blankenburg K.P.
,
Davis C.
,
Delgado O.
,
Dinh H.H.
,
Draper H.
,
Gonzalez-Garay M.L.
,
Havlak P.
,
Jackson L.R.
,
Jacob L.S.
,
Kelly S.H.
,
Li L.
,
Li Z.
,
Liu J.
,
Liu W.
,
Lu J.
,
Maheshwari M.
,
Nguyen B.-V.
,
Okwuonu G.O.
,
Pasternak S.
,
Perez L.M.
,
Plopper F.J.H.
,
Santibanez J.
,
Shen H.
,
Tabor P.E.
,
Verduzco D.
,
Waldron L.
,
Wang Q.
,
Williams G.A.
,
Zhang J.
,
Zhou J.
,
Allen C.C.
,
Amin A.G.
,
Anyalebechi V.
,
Bailey M.
,
Barbaria J.A.
,
Bimage K.E.
,
Bryant N.P.
,
Burch P.E.
,
Burkett C.E.
,
Burrell K.L.
,
Calderon E.
,
Cardenas V.
,
Carter K.
,
Casias K.
,
Cavazos I.
,
Cavazos S.R.
,
Ceasar H.
,
Chacko J.
,
Chan S.N.
,
Chavez D.
,
Christopoulos C.
,
Chu J.
,
Cockrell R.
,
Cox C.D.
,
Dang M.
,
Dathorne S.R.
,
David R.
,
Davis C.M.
,
Davy-Carroll L.
,
Deshazo D.R.
,
Donlin J.E.
,
D'Souza L.
,
Eaves K.A.
,
Egan A.
,
Emery-Cohen A.J.
,
Escotto M.
,
Flagg N.
,
Forbes L.D.
,
Gabisi A.M.
,
Garza M.
,
Hamilton C.
,
Henderson N.
,
Hernandez O.
,
Hines S.
,
Hogues M.E.
,
Huang M.
,
Idlebird D.G.
,
Johnson R.
,
Jolivet A.
,
Jones S.
,
Kagan R.
,
King L.M.
,
Leal B.
,
Lebow H.
,
Lee S.
,
LeVan J.M.
,
Lewis L.C.
,
London P.
,
Lorensuhewa L.M.
,
Loulseged H.
,
Lovett D.A.
,
Lucier A.
,
Lucier R.L.
,
Ma J.
,
Madu R.C.
,
Mapua P.
,
Martindale A.D.
,
Martinez E.
,
Massey E.
,
Mawhiney S.
,
Meador M.G.
,
Mendez S.
,
Mercado C.
,
Mercado I.C.
,
Merritt C.E.
,
Miner Z.L.
,
Minja E.
,
Mitchell T.
,
Mohabbat F.
,
Mohabbat K.
,
Montgomery B.
,
Moore N.
,
Morris S.
,
Munidasa M.
,
Ngo R.N.
,
Nguyen N.B.
,
Nickerson E.
,
Nwaokelemeh O.O.
,
Nwokenkwo S.
,
Obregon M.
,
Oguh M.
,
Oragunye N.
,
Oviedo R.J.
,
Parish B.J.
,
Parker D.N.
,
Parrish J.
,
Parks K.L.
,
Paul H.A.
,
Payton B.A.
,
Perez A.
,
Perrin W.
,
Pickens A.
,
Primus E.L.
,
Pu L.-L.
,
Puazo M.
,
Quiles M.M.
,
Quiroz J.B.
,
Rabata D.
,
Reeves K.
,
Ruiz S.J.
,
Shao H.
,
Sisson I.
,
Sonaike T.
,
Sorelle R.P.
,
Sutton A.E.
,
Svatek A.F.
,
Svetz L.A.
,
Tamerisa K.S.
,
Taylor T.R.
,
Teague B.
,
Thomas N.
,
Thorn R.D.
,
Trejos Z.Y.
,
Trevino B.K.
,
Ukegbu O.N.
,
Urban J.B.
,
Vasquez L.I.
,
Vera V.A.
,
Villasana D.M.
,
Wang L.
,
Ward-Moore S.
,
Warren J.T.
,
Wei X.
,
White F.
,
Williamson A.L.
,
Wleczyk R.
,
Wooden H.S.
,
Wooden S.H.
,
Yen J.
,
Yoon L.
,
Yoon V.
,
Zorrilla S.E.
,
Nelson D.
,
Kucherlapati R.
,
Weinstock G.
,
Gibbs R.A.
more...
Nature440:346-351(2006)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.
Mural R.J.
,
Istrail S.
,
Sutton G.
,
Florea L.
,
Halpern A.L.
,
Mobarry C.M.
,
Lippert R.
,
Walenz B.
,
Shatkay H.
,
Dew I.
,
Miller J.R.
,
Flanigan M.J.
,
Edwards N.J.
,
Bolanos R.
,
Fasulo D.
,
Halldorsson B.V.
,
Hannenhalli S.
,
Turner R.
,
Yooseph S.
,
Lu F.
,
Nusskern D.R.
,
Shue B.C.
,
Zheng X.H.
,
Zhong F.
,
Delcher A.L.
,
Huson D.H.
,
Kravitz S.A.
,
Mouchard L.
,
Reinert K.
,
Remington K.A.
,
Clark A.G.
,
Waterman M.S.
,
Eichler E.E.
,
Adams M.D.
,
Hunkapiller M.W.
,
Myers E.W.
,
Venter J.C.
more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases
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Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue :
Testis .
7.
"MAPK upstream kinase (MUK)-binding inhibitory protein, a negative regulator of MUK/Dual leucine zipper-bearing kinase/leucine zipper protein kinase."
Fukuyama K.
,
Yoshida M.
,
Yamashita A.
,
Deyama T.
,
Baba M.
,
Suzuki A.
,
Mohri H.
,
Ikezawa Z.
,
Nakajima H.
,
Hirai S.
,
Ohno S.
J. Biol. Chem.275:21247-21254(2000)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
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Cited for : INTERACTION WITH MBIP
8.
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Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Leukemic T-cell .
10.
"Patterns of somatic mutation in human cancer genomes."
Greenman C.
,
Stephens P.
,
Smith R.
,
Dalgliesh G.L.
,
Hunter C.
,
Bignell G.
,
Davies H.
,
Teague J.
,
Butler A.
,
Stevens C.
,
Edkins S.
,
O'Meara S.
,
Vastrik I.
,
Schmidt E.E.
,
Avis T.
,
Barthorpe S.
,
Bhamra G.
,
Buck G.
,
Choudhury B.
,
Clements J.
,
Cole J.
,
Dicks E.
,
Forbes S.
,
Gray K.
,
Halliday K.
,
Harrison R.
,
Hills K.
,
Hinton J.
,
Jenkinson A.
,
Jones D.
,
Menzies A.
,
Mironenko T.
,
Perry J.
,
Raine K.
,
Richardson D.
,
Shepherd R.
,
Small A.
,
Tofts C.
,
Varian J.
,
Webb T.
,
West S.
,
Widaa S.
,
Yates A.
,
Cahill D.P.
,
Louis D.N.
,
Goldstraw P.
,
Nicholson A.G.
,
Brasseur F.
,
Looijenga L.
,
Weber B.L.
,
Chiew Y.-E.
,
DeFazio A.
,
Greaves M.F.
,
Green A.R.
,
Campbell P.
,
Birney E.
,
Easton D.F.
,
Chenevix-Trench G.
,
Tan M.-H.
,
Khoo S.K.
,
Teh B.T.
,
Yuen S.T.
,
Leung S.Y.
,
Wooster R.
,
Futreal P.A.
,
Stratton M.R.
more...
Nature446:153-158(2007)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
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Cited for : VARIANTS [LARGE SCALE ANALYSIS] LYS-409; ARG-628 AND SER-640