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Index > Protein center > MAP3K12(Gene name) > Human
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  • MAP3K12 (Gene name),
  • Mitogen-activated protein kinase kinase kinase 12 (Protein name ),  M3K12_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    MAP3K12(ZPK);
    Protein name:
    Mitogen-activated protein kinase kinase kinase 12;
    Alternative:
    Leucine-zipper protein kinase(ZPK);Dual leucine zipper bearing kinase(DLK);Mixed lineage kinase;MAPK-upstream kinase(MUK);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with MBIP.
    Function:
    May be an activator of the JNK/SAPK pathway. Phosphorylates beta-casein, histone 1 and myelin basic protein in vitro.
    Subcellular Location:
    Cytoplasm Membrane Peripheral membrane protein
    Protein Attributes:
    Sequence length:
    859
    Sequence:
    50:
    MACLHETRTP | SPSFGGFVST | LSEASMRKLD | PDTSDCTPEK | DLTPTHVLQL | 
    100:
    HEQDAGGPGG | AAGSPESRAS | RVRADEVRLQ | CQSGSGFLEG | LFGCLRPVWT | 
    150:
    MIGKAYSTEH | KQQQEDLWEV | PFEEILDLQW | VGSGAQGAVF | LGRFHGEEVA | 
    200:
    VKKVRDLKET | DIKHLRKLKH | PNIITFKGVC | TQAPCYCILM | EFCAQGQLYE | 
    250:
    VLRAGRPVTP | SLLVDWSMGI | AGGMNYLHLH | KIIHRDLKSP | NMLITYDDVV | 
    300:
    KISDFGTSKE | LSDKSTKMSF | AGTVAWMAPE | VIRNEPVSEK | VDIWSFGVVL | 
    350:
    WELLTGEIPY | KDVDSSAIIW | GVGSNSLHLP | VPSSCPDGFK | ILLRQCWNSK | 
    400:
    PRNRPSFRQI | LLHLDIASAD | VLSTPQETYF | KSQAEWREEV | KLHFEKIKSE | 
    450:
    GTCLHRLEEE | LVMRRREELR | HALDIREHYE | RKLERANNLY | MELNALMLQL | 
    500:
    ELKERELLRR | EQALERRCPG | LLKPHPSRGL | LHGNTMEKLI | KKRNVPQKLS | 
    550:
    PHSKRPDILK | TESLLPKLDA | ALSGVGLPGC | PKGPPSPGRS | RRGKTRHRKA | 
    600:
    SAKGSCGDLP | GLRTAVPPHE | PGGPGSPGGL | GGGPSAWEAC | PPALRGLHHD | 
    650:
    LLLRKMSSSS | PDLLSAALGS | RGRGATGGAG | DPGSPPPARG | DTPPSEGSAP | 
    700:
    GSTSPDSPGG | AKGEPPPPVG | PGEGVGLLGT | GREGTSGRGG | SRAGSQHLTP | 
    750:
    AALLYRAAVT | RSQKRGISSE | EEEGEVDSEV | ELTSSQRWPQ | SLNMRQSLST | 
    800:
    FSSENPSDGE | EGTASEPSPS | GTPEVGSTNT | DERPDERSDD | MCSQGSEIPL | 
    850:
    DPPPSEVIPG | PEPSSLPIPH | QELLRERGPP | NSEDSDCDST | ELDNSNSVDA | 
    859:
    LRPPASLPP
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    String:
    MIM:
    Pfam:
    UniGene:
    KEGG:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Human Mitogen-activated protein kinase kinase kinase 12
    ELISA Kit for Human Mitogen-activated protein kinase kinase kinase 12
    ELISA Kit for Human Mitogen-activated protein kinase kinase kinase 12
    CLIA Kit for Human Mitogen-activated protein kinase kinase kinase 12
    CLIA Kit for Human Mitogen-activated protein kinase kinase kinase 12
    CLIA Kit for Human Mitogen-activated protein kinase kinase kinase 12
    Polyclonal Antibody for Human Mitogen-activated protein kinase kinase kinase 12
    Polyclonal Antibody for Human Mitogen-activated protein kinase kinase kinase 12
    Polyclonal Antibody for Human Mitogen-activated protein kinase kinase kinase 12
    Monoclonal Antibody for Human Mitogen-activated protein kinase kinase kinase 12
    Monoclonal Antibody for Human Mitogen-activated protein kinase kinase kinase 12
    Monoclonal Antibody for Human Mitogen-activated protein kinase kinase kinase 12
    Protein for Human Mitogen-activated protein kinase kinase kinase 12
    Protein for Human Mitogen-activated protein kinase kinase kinase 12
    Protein for Human Mitogen-activated protein kinase kinase kinase 12

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Cloning of a novel putative protein kinase having a leucine zipper domain from human brain."
      Reddy U.R. , Pleasure D.
      Biochem. Biophys. Res. Commun.202:613-620(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Teratocarcinoma.
    2. 2.
      "SP3 acts as a positive regulator on the core promoter of human ZPK gene."
      Itoh A. , Wang Z. , Ito Y. , Reddy U.R. , Itoh T.
      Biochem. Biophys. Res. Commun.313:612-618(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    3. 3.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
    4. 4.
      "The finished DNA sequence of human chromosome 12."
      Scherer S.E. , Muzny D.M. , Buhay C.J. , Chen R. , Cree A. , Ding Y. , Dugan-Rocha S. , Gill R. , Gunaratne P. , Harris R.A. , Hawes A.C. , Hernandez J. , Hodgson A.V. , Hume J. , Jackson A. , Khan Z.M. , Kovar-Smith C. , Lewis L.R. , more...
      Nature440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Testis.
    7. 7.
      "MAPK upstream kinase (MUK)-binding inhibitory protein, a negative regulator of MUK/Dual leucine zipper-bearing kinase/leucine zipper protein kinase."
      Fukuyama K. , Yoshida M. , Yamashita A. , Deyama T. , Baba M. , Suzuki A. , Mohri H. , Ikezawa Z. , Nakajima H. , Hirai S. , Ohno S.
      J. Biol. Chem.275:21247-21254(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MBIP
    8. 8.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    9. 9.
      "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
      Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Leukemic T-cell.
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