Map3k2 ELISA Kit for Mouse(Mus musculus) | EIAab.comMap3k2 ELISA Kit for Mouse(Mus musculus)

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Map3k2 (Gene name),

Mitogen-activated protein kinase kinase kinase 2 (Protein name ), M3K2_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Map3k2(Mekk2);

Protein name:

Mitogen-activated protein kinase kinase kinase 2;

Alternative:

MAPK/ERK kinase kinase 2(MEK kinase 2;MEKK 2);

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Self-associates (By similarity). Binds both upstream activators and downstream substrates in multimolecular complexes. Interacts (via the kinase catalytic domain) with STK38.

Function:

Component of a protein kinase signal transduction cascade. Regulates the JNK and ERK5 pathways by phosphorylating and activating MAP2K5 and MAP2K7. Plays a role in caveolae kiss-and-run dynamics.

Subcellular Location:

Cytoplasm Nucleus Upon EGF stimulation, translocates into the nucleus.

Protein Attributes:

Sequence length:

619

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

619:

AKLRPSAEEL | LRHMFVHYH

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

STRING:

10090.ENSMUSP00000094326

UniGene:

Mm.211762

String:

Q61083

Pfam:

PF00564

SMR:

Q61083

Uniprot:

Q61083

FOR

ELISA Kit for Mouse Mitogen-activated protein kinase kinase kinase 2

CLIA Kit for Mouse Mitogen-activated protein kinase kinase kinase 2

Polyclonal Antibody for Mouse Mitogen-activated protein kinase kinase kinase 2

Monoclonal Antibody for Mouse Mitogen-activated protein kinase kinase kinase 2

Protein for Mouse Mitogen-activated protein kinase kinase kinase 2

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Molecular cloning of mitogen-activated protein/ERK kinase kinases (MEKK) 2 and 3. Regulation of sequential phosphorylation pathways involving mitogen-activated protein kinase and c-Jun kinase."
Blank J.L. , Gerwins P. , Elliott E.M. , Sather S. , Johnson G.L.
J. Biol. Chem.271:5361-5368(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Brain.
2.

"MEK kinase 2 binds and activates protein kinase C-related kinase 2. Bifurcation of kinase regulatory pathways at the level of an MAPK kinase kinase."
Sun W. , Vincent S. , Settleman J. , Johnson G.L.
J. Biol. Chem.275:24421-24428(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PKN2
3.

"Mutations in protein kinase subdomain X differentially affect MEKK2 and MEKK1 activity."
Huang J. , Tu Z. , Lee F.S.
Biochem. Biophys. Res. Commun.303:532-540(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;AUTOPHOSPHORYLATION;MUTAGENESIS OF PHE-571; ISO-573; THR-575; GLN-576; PRO-577; PRO-580; LEU-582; PRO-583 AND VAL-586
4.

"PB1 domains of MEKK2 and MEKK3 interact with the MEK5 PB1 domain for activation of the ERK5 pathway."
Nakamura K. , Johnson G.L.
J. Biol. Chem.278:36989-36992(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MAP2K5
5.

"Large-scale phosphorylation analysis of mouse liver."
Villen J. , Beausoleil S.A. , Gerber S.A. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-331;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Liver.

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