Protein name:
Mitogen-activated protein kinase kinase kinase 7 ;
Alternative:
Organism:
Bovine (Bos taurus).
General Annotation
Sub Unit:
Binds both upstream activators and downstream substrates in multimolecular complexes. Interacts with TAB1/MAP3K7IP1 and TAB2/MAP3K7IP2. Identified in the TRIKA2 complex composed of MAP3K7, TAB1/MAP3K7IP1 and TAB2/MAP3K7IP2. Interacts with PPM1L. Interaction with PP2A and PPP6C leads to its repressed activity. Interacts with TRAF6 and TAB1/MAP3K7IP1; during IL-1 signaling. Interacts with TAOK1 and TAOK2; interaction with TAOK2 interferes with MAP3K7 interaction with IKKA, thus preventing NF-kappa-B activation. Interacts with WDR34 (via WD domains). Interacts with RBCK1. Interacts with CYLD. Interacts with TGFBR1; induces MAP3K7 activation by TRAF6 (By similarity). Interacts with MAPK8IP1 and VRK2.
Function:
Component of a protein kinase signal transduction cascade. Mediator of TRAF6 and TGF-beta signal transduction. Activates IKBKB and MAPK8 in response to TRAF6 signaling. Stimulates NF-kappa-B activation and the p38 MAPK pathway. In osmotic stress signaling, plays a major role in the activation of MAPK8/JNK, but not that of NF-kappa-B.
Subcellular Location:
N/A
Protein Attributes:
50:
MSTASAASSS | SSSSAGEMIE | APSQVLNFEE | IDYKEIEVEE | VVGRGAFGVV |
100:
CKAKWRAKDV | AIKQIESESE | RKAFIVELRQ | LSRVNHPNIV | KLYGACLNPV |
150:
CLVMEYAEGG | SLYNVLHGAE | PLPYYTAAHA | MSWCLQCSQG | VAYLHSMQPK |
200:
ALIHRDLKPP | NLLLVAGGTV | LKICDFGTAC | DIQTHMTNNK | GSAAWMAPEV |
250:
FEGSNYSEKC | DVFSWGIILW | EVITRRKPFD | EIGGPAFRIM | WAVHNGTRPP |
300:
LIKNLPKPIE | SLMTRCWSKD | PSQRPSMEEI | VKIMTHLMRY | FPGADEPLQY |
350:
PCQYSDEGQS | NSATSTGSFM | DITSTNTSNK | SDTNMEQVPA | TNDTIKRLES |
400:
KLLKNQAKQQ | SESGRLSLGA | SRGSSVESLP | PTSEGKRMSA | DMSEIEARIA |
450:
ATTGNGQPRR | RSIQDLTVTG | TDPGQVSSRS | SSPSVRMITT | SGPTSEKPAR |
500:
SHPWTPDDST | DTNGSDNSIP | MAYLTLDHQL | QPLAPCPNSK | ESMAVFEQHC |
550:
KMAQEYMKVQ | TEIALLLQRK | QELVAELDQD | EKDQQNTSRL | VQEHKKLLDE |
579:
NKSLSTYYQQ | CKKQLEVIRS | QQQKRQGTS
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Bovine
Rat
Human
Mouse
ELISA Kit for Bovine Mitogen-activated protein kinase kinase kinase 7
ELISA Kit for Bovine Mitogen-activated protein kinase kinase kinase 7
ELISA Kit for Bovine Mitogen-activated protein kinase kinase kinase 7
ELISA Kit for Bovine Mitogen-activated protein kinase kinase kinase 7
CLIA Kit for Bovine Mitogen-activated protein kinase kinase kinase 7
CLIA Kit for Bovine Mitogen-activated protein kinase kinase kinase 7
CLIA Kit for Bovine Mitogen-activated protein kinase kinase kinase 7
CLIA Kit for Bovine Mitogen-activated protein kinase kinase kinase 7
Polyclonal Antibody for Bovine Mitogen-activated protein kinase kinase kinase 7
Polyclonal Antibody for Bovine Mitogen-activated protein kinase kinase kinase 7
Polyclonal Antibody for Bovine Mitogen-activated protein kinase kinase kinase 7
Polyclonal Antibody for Bovine Mitogen-activated protein kinase kinase kinase 7
Monoclonal Antibody for Bovine Mitogen-activated protein kinase kinase kinase 7
Monoclonal Antibody for Bovine Mitogen-activated protein kinase kinase kinase 7
Monoclonal Antibody for Bovine Mitogen-activated protein kinase kinase kinase 7
Monoclonal Antibody for Bovine Mitogen-activated protein kinase kinase kinase 7
Protein for Bovine Mitogen-activated protein kinase kinase kinase 7
Protein for Bovine Mitogen-activated protein kinase kinase kinase 7
Protein for Bovine Mitogen-activated protein kinase kinase kinase 7
Protein for Bovine Mitogen-activated protein kinase kinase kinase 7
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
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Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain :
Hereford .
tissue :
Ascending colon .