MAP3K7 ELISA Kit for Human(Homo sapiens) | EIAab.comMAP3K7 ELISA Kit for Human(Homo sapiens)

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MAP3K7 (Gene name),

Mitogen-activated protein kinase kinase kinase 7 (Protein name ), M3K7_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

MAP3K7(TAK1);

Protein name:

Mitogen-activated protein kinase kinase kinase 7;

Alternative:

Transforming growth factor-beta-activated kinase 1(TGF-beta-activated kinase 1);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Binds both upstream activators and downstream substrates in multimolecular complexes. Interacts with TAB1/MAP3K7IP1 and TAB2/MAP3K7IP2. Identified in the TRIKA2 complex composed of MAP3K7, TAB1/MAP3K7IP1 and TAB2/MAP3K7IP2. Interacts with PPM1L. Interaction with PP2A and PPP6C leads to its repressed activity. Interacts with TRAF6 and TAB1/MAP3K7IP1; during IL-1 signaling. Interacts with TAOK1 and TAOK2; interaction with TAOK2 interferes with MAP3K7 interaction with IKKA, thus preventing NF-kappa-B activation. Interacts with WDR34 (via WD domains). Interacts with RBCK1. Interacts with CYLD. Interacts with TGFBR1; induces MAP3K7 activation by TRAF6. Interacts with MAPK8IP1 (By similarity). Interacts with isoform 1 of VRK2.

Function:

Component of a protein kinase signal transduction cascade. Mediator of TRAF6 and TGF-beta signal transduction. Activates IKBKB and MAPK8 in response to TRAF6 signaling. Stimulates NF-kappa-B activation and the p38 MAPK pathway. In osmotic stress signaling, plays a major role in the activation of MAPK8/JNK, but not that of NF-kappa-B.

Subcellular Location:

N/A

Protein Attributes:

Sequence length:

606

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

606:

KRQGTS

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Hs.594838

SMR:

O43318

MIM:

602614

Pfam:

PF07714

UniGene:

Hs.722892

KEGG:

hsa:6885

String:

O43318

STRING:

9606.ENSP00000358335

Uniprot:

O43318

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ELISA Kit for Human Mitogen-activated protein kinase kinase kinase 7

Cat.:

E10349b

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96T

ELISA Kit for Human Mitogen-activated protein kinase kinase kinase 7

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E10349r

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96T

ELISA Kit for Human Mitogen-activated protein kinase kinase kinase 7

Cat.:

E10349h

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96T

ELISA Kit for Human Mitogen-activated protein kinase kinase kinase 7

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E10349m

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96T

CLIA Kit for Human Mitogen-activated protein kinase kinase kinase 7

Cat.:

U10349m

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Packing:

96T

CLIA Kit for Human Mitogen-activated protein kinase kinase kinase 7

Cat.:

U10349r

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Packing:

96T

CLIA Kit for Human Mitogen-activated protein kinase kinase kinase 7

Cat.:

U10349b

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Packing:

96T

CLIA Kit for Human Mitogen-activated protein kinase kinase kinase 7

Cat.:

U10349h

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96T

Polyclonal Antibody for Human Mitogen-activated protein kinase kinase kinase 7

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P10349Rb-m

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40ug/0.2ml

Polyclonal Antibody for Human Mitogen-activated protein kinase kinase kinase 7

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P10349Rb-r

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40ug/0.2ml

Polyclonal Antibody for Human Mitogen-activated protein kinase kinase kinase 7

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P10349Rb-h

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40ug/0.2ml

Monoclonal Antibody for Human Mitogen-activated protein kinase kinase kinase 7

Protein for Human Mitogen-activated protein kinase kinase kinase 7

R&D Technical Data

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Precision

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Recovery

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References

1.

"TGF-beta-activated kinase 1 stimulates NF-kappa B activation by an NF-kappa B-inducing kinase-independent mechanism."
Sakurai H. , Shigemori N. , Hasegawa K. , Sugita T.
Biochem. Biophys. Res. Commun.243:545-549(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1A; 1B AND 1C)
tissue: Lung.
2.

"Alternative splicing and gene structure of the transforming growth factor beta-activated kinase 1."
Dempsey C.E. , Sakurai H. , Sugita T. , Guesdon F.
Biochim. Biophys. Acta1517:46-52(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1D);TISSUE SPECIFICITY
3.

NHLBI resequencing and genotyping service (RS&G)
Submitted (2005-12) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
4.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1A)
tissue: Trachea.
5.

"The DNA sequence and analysis of human chromosome 6."
Mungall A.J. , Palmer S.A. , Sims S.K. , Edwards C.A. , Ashurst J.L. , Wilming L. , Jones M.C. , Horton R. , Hunt S.E. , Scott C.E. , Gilbert J.G.R. , Clamp M.E. , Bethel G. , Milne S. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Andrews T.D. , more...
Nature425:805-811(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
7.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1A)
tissue: Uterus.
8.

"A novel kinase cascade mediated by mitogen-activated protein kinase kinase 6 and MKK3."
Moriguchi T. , Kuroyanagi N. , Yamaguchi K. , Gotoh Y. , Irie K. , Kano T. , Shirakabe K. , Muro Y. , Shibuya H. , Matsumoto K. , Nishida E. , Hagiwara M.
J. Biol. Chem.271:13675-13679(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF MAP2K3/MKK3 AND MAP2K6/MKK6
9.

"TAB1: an activator of the TAK1 MAPKKK in TGF-beta signal transduction."
Shibuya H. , Yamaguchi K. , Shirakabe K. , Tonegawa A. , Gotoh Y. , Ueno N. , Irie K. , Nishida E. , Matsumoto K.
Science272:1179-1182(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TAB1/MAP3K7IP1
10.

"TAK1 mediates the ceramide signaling to stress-activated protein kinase/c-Jun N-terminal kinase."
Shirakabe K. , Yamaguchi K. , Shibuya H. , Irie K. , Matsuda S. , Moriguchi T. , Gotoh Y. , Matsumoto K. , Nishida E.
J. Biol. Chem.272:8141-8144(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ENZYME REGULATION;FUNCTION
11.

"The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway."
Ninomiya-Tsuji J. , Kishimoto K. , Hiyama A. , Inoue J. , Cao Z. , Matsumoto K.
Nature398:252-256(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TRAF6 AND TAB1/MAP3K7IP1;FUNCTION
12.

"Phosphorylation-dependent activation of TAK1 mitogen-activated protein kinase kinase kinase by TAB1."
Sakurai H. , Miyoshi H. , Mizukami J. , Sugita T.
FEBS Lett.474:141-145(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TAB1;PHOSPHORYLATION AT THR-184; THR-187 AND SER-192;ACTIVATION
13.

"TAK1 mitogen-activated protein kinase kinase kinase is activated by autophosphorylation within its activation loop."
Kishimoto K. , Matsumoto K. , Ninomiya-Tsuji J.
J. Biol. Chem.275:7359-7364(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-192;ENZYME REGULATION
14.

"Regulation of the TAK1 signaling pathway by protein phosphatase 2C."
Hanada M. , Ninomiya-Tsuji J. , Komaki K. , Ohnishi M. , Katsura K. , Kanamaru R. , Matsumoto K. , Tamura S.
J. Biol. Chem.276:5753-5759(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DEPHOSPHORYLATION BY PPM1B/PP2CB;INTERACTION WITH PPM1B/PP2CB
15.

"TAK1 is a ubiquitin-dependent kinase of MKK and IKK."
Wang C. , Deng L. , Hong M. , Akkaraju G.R. , Inoue J. , Chen Z.J.
Nature412:346-351(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBIQUITINATION;FUNCTION;ENZYME REGULATION;INTERACTION WITH TAB1/MAP3K7IP2 AND TAB2/MAP3K7IP2;IDENTIFICATION IN THE TRIKA2 COMPLEX
16.

"Interleukin-1 (IL-1) receptor-associated kinase-dependent IL-1-induced signaling complexes phosphorylate TAK1 and TAB2 at the plasma membrane and activate TAK1 in the cytosol."
Jiang Z. , Ninomiya-Tsuji J. , Qian Y. , Matsumoto K. , Li X.
Mol. Cell. Biol.22:7158-7167(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH IRAK; TAB1/MAP3K7IP1; TAB2/MAP3K7IP2 AND TRAF6;PHOSPHORYLATION;ENZYME REGULATION;SUBCELLULAR LOCATION
17.

"Pellino2 activates the mitogen activated protein kinase pathway."
Jensen L.E. , Whitehead A.S.
FEBS Lett.545:199-202(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PELI1 AND PELI2
18.

"Pellino3, a novel member of the Pellino protein family, promotes activation of c-Jun and Elk-1 and may act as a scaffolding protein."
Jensen L.E. , Whitehead A.S.
J. Immunol.171:1500-1506(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PELI3
19.

"Transforming growth factor-beta1 (TGF-beta)-induced apoptosis of prostate cancer cells involves Smad7-dependent activation of p38 by TGF-beta-activated kinase 1 and mitogen-activated protein kinase kinase 3."
Edlund S. , Bu S. , Schuster N. , Aspenstroem P. , Heuchel R. , Heldin N.E. , ten Dijke P. , Heldin C.H. , Landstrom M.
Mol. Biol. Cell14:529-544(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH SMAD7; MAP2K3 AND P38 KINASE;MUTAGENESIS OF LYS-63
20.

"TAB3, a new binding partner of the protein kinase TAK1."
Cheung P.C. , Nebreda A.R. , Cohen P.
Biochem. J.378:27-34(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TAB3/MAP3K7IP3
21.

"Disabled-2 (Dab2) mediates transforming growth factor beta (TGFbeta)-stimulated fibronectin synthesis through TGFbeta-activated kinase 1 and activation of the JNK pathway."
Hocevar B.A. , Prunier C. , Howe P.H.
J. Biol. Chem.280:25920-25927(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH DAB2
22.

"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Olsen J.V. , Blagoev B. , Gnad F. , Macek B. , Kumar C. , Mortensen P. , Mann M.
Cell127:635-648(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-439;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
23.

"The Yersinia enterocolitica effector YopP inhibits host cell signalling by inactivating the protein kinase TAK1 in the IL-1 signalling pathway."
Thiefes A. , Wolf A. , Doerrie A. , Grassl G.A. , Matsumoto K. , Autenrieth I. , Bohn E. , Sakurai H. , Niedenthal R. , Resch K. , Kracht M.
EMBO Rep.7:838-844(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBIQUITINATION;PHOSPHORYLATION AT THR-187 BY AUTOCATALYSIS;SUBUNIT;FUNCTION
24.

"Osmotic stress activates the TAK1-JNK pathway while blocking TAK1-mediated NF-kappaB activation: TAO2 regulates TAK1 pathways."
Huangfu W.C. , Omori E. , Akira S. , Matsumoto K. , Ninomiya-Tsuji J.
J. Biol. Chem.281:28802-28810(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;ENZYME REGULATION;INTERACTION WITH TAOK1 AND TAOK2
25.

"Protein phosphatase 6 down-regulates TAK1 kinase activation in the IL-1 signaling pathway."
Kajino T. , Ren H. , Iemura S. , Natsume T. , Stefansson B. , Brautigan D.L. , Matsumoto K. , Ninomiya-Tsuji J.
J. Biol. Chem.281:39891-39896(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PP2A AND PPP6C;DEPHOSPHORYLATION AT THR-187 BY PP2A AND PPP6C
26.

"RBCK1 negatively regulates tumor necrosis factor- and interleukin-1-triggered NF-kappaB activation by targeting TAB2/3 for degradation."
Tian Y. , Zhang Y. , Zhong B. , Wang Y.Y. , Diao F.C. , Wang R.P. , Zhang M. , Chen D.Y. , Zhai Z.H. , Shu H.B.
J. Biol. Chem.282:16776-16782(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RBCK1
27.

"Deubiquitinating enzyme CYLD negatively regulates the ubiquitin-dependent kinase Tak1 and prevents abnormal T cell responses."
Reiley W.W. , Jin W. , Lee A.J. , Wright A. , Wu X. , Tewalt E.F. , Leonard T.O. , Norbury C.C. , Fitzpatrick L. , Zhang M. , Sun S.C.
J. Exp. Med.204:1475-1485(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBIQUITINATION;INTERACTION WITH CYLD;DEUBIQUITINATION BY CYLD
28.

"Phosphoproteome of resting human platelets."
Zahedi R.P. , Lewandrowski U. , Wiesner J. , Wortelkamp S. , Moebius J. , Schuetz C. , Walter U. , Gambaryan S. , Sickmann A.
J. Proteome Res.7:526-534(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-439;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Platelet.
29.

"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
Daub H. , Olsen J.V. , Bairlein M. , Gnad F. , Oppermann F.S. , Korner R. , Greff Z. , Keri G. , Stemmann O. , Mann M.
Mol. Cell31:438-448(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-439;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
30.

"The type I TGF-beta receptor engages TRAF6 to activate TAK1 in a receptor kinase-independent manner."
Sorrentino A. , Thakur N. , Grimsby S. , Marcusson A. , von Bulow V. , Schuster N. , Zhang S. , Heldin C.H. , Landstrom M.
Nat. Cell Biol.10:1199-1207(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TGFBR1
31.

"Modulation of interleukin-1 transcriptional response by the interaction between VRK2 and the JIP1 scaffold protein."
Blanco S. , Sanz-Garcia M. , Santos C.R. , Lazo P.A.
PLoS ONE3:E1660-E1660(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH VRK2
32.

"A quantitative atlas of mitotic phosphorylation."
Dephoure N. , Zhou C. , Villen J. , Beausoleil S.A. , Bakalarski C.E. , Elledge S.J. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-389 AND SER-439;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
33.

"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
34.

"WDR34 is a novel TAK1-associated suppressor of the IL-1R/TLR3/TLR4-induced NF-kappaB activation pathway."
Gao D. , Wang R. , Li B. , Yang Y. , Zhai Z. , Chen D.Y.
Cell. Mol. Life Sci.66:2573-2584(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH WDR34
35.

"Large-scale proteomics analysis of the human kinome."
Oppermann F.S. , Gnad F. , Olsen J.V. , Hornberger R. , Greff Z. , Keri G. , Mann M. , Daub H.
Mol. Cell. Proteomics8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-389 AND SER-439;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
36.

"Direct activation of protein kinases by unanchored polyubiquitin chains."
Xia Z.-P. , Sun L. , Chen X. , Pineda G. , Jiang X. , Adhikari A. , Zeng W. , Chen Z.J.
Nature461:114-119(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TAB2;PHOSPHORYLATION AT THR-187
37.

"Ubiquitin-mediated activation of TAK1 and IKK."
Adhikari A. , Xu M. , Chen Z.J.
Oncogene26:3214-3226(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON ENZYME REGULATION
38.

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-389 AND SER-439;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Leukemic T-cell.
39.

"The TAK1-TRAF6 signalling pathway."
Landstrom M.
Int. J. Biochem. Cell Biol.42:585-589(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON ENZYME REGULATION;REVIEW ON FUNCTION
40.

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-439;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
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BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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"TRIM5 is an innate immune sensor for the retrovirus capsid lattice."
Pertel T. , Hausmann S. , Morger D. , Zueger S. , Guerra J. , Lascano J. , Reinhard C. , Santoni F.A. , Uchil P.D. , Chatel L. , Bisiaux A. , Albert M.L. , Strambio-De-Castillia C. , Mothes W. , Pizzato M. , Gruetter M.G. , Luban J.
Nature472:361-365(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH TRIM5;PHOSPHORYLATION AT THR-187
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"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T. , Prokhorova T.A. , Akimov V. , Henningsen J. , Johansen P.T. , Kratchmarova I. , Kassem M. , Mann M. , Olsen J.V. , Blagoev B.
Sci. Signal.4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-389 AND SER-439;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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"Lys48-linked TAK1 polyubiquitination at lysine-72 downregulates TNFalpha-induced NF-kappaB activation via mediating TAK1 degradation."
Fan Y. , Shi Y. , Liu S. , Mao R. , An L. , Zhao Y. , Zhang H. , Zhang F. , Xu G. , Qin J. , Yang J.
Cell. Signal.24:1381-1389(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBIQUITINATION AT LYS-72
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"Structural basis for the interaction of TAK1 kinase with its activating protein TAB1."
Brown K. , Vial S.C. , Dedi N. , Long J.M. , Dunster N.J. , Cheetham G.M.T.
J. Mol. Biol.354:1013-1020(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 31-328 IN COMPLEX WITH TAB1 AND ADENOSINE

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