MAN2B1 ELISA Kit for Human(Homo sapiens) | EIAab.comMAN2B1 ELISA Kit for Human(Homo sapiens)

Search Protein-oriented Product center.

For antibodies, ELISA/CLIA, proteins... Product center

Tips

Index > Protein center > MAN2B1(Gene name) > Human

MAN2B1 (Gene name),

Lysosomal alpha-mannosidase (Protein name ), MA2B1_HUMAN from NCBI database.

top

General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

Feedback

Gene name:

MAN2B1(LAMAN;MANB);

Protein name:

Lysosomal alpha-mannosidase(Laman);

Alternative:

Mannosidase alpha class 2B member 1;Lysosomal acid alpha-mannosidase;Mannosidase alpha-B;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

N/A

Function:

Necessary for the catabolism of N-linked carbohydrates released during glycoprotein turnover. Cleaves all known types of alpha-mannosidic linkages.

Subcellular Location:

Lysosome

Protein Attributes:

Sequence length:

1011

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

750:

800:

850:

900:

950:

1000:

1011:

LASVQWKEVD | G

3D Structure:

N/A

Predicted Eptitope:

Please Sign in.

Vaild Sequence:

Please Sign in.

Related Databases

SMR:

O00754

MIM:

248500

STRING:

9606.ENSP00000395473

KEGG:

hsa:4125

Pfam:

PF09261

String:

O00754

UniGene:

Hs.356769

Uniprot:

O00754

FOR

ELISA Kit for Human Laman

CLIA Kit for Human Laman

Polyclonal Antibody for Human Laman

Monoclonal Antibody for Human Laman

Protein for Human Laman

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Human lysosomal alpha-mannosidase: isolation and nucleotide sequence of the full-length cDNA."
Nebes V.L. , Schmidt M.C.
Biochem. Biophys. Res. Commun.200:239-245(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
2.

"Alpha-mannosidosis: functional cloning of the lysosomal alpha-mannosidase cDNA and identification of a mutation in two affected siblings."
Nilssen O. , Berg T. , Riise H.M.F. , Ramachandran U. , Evjen G. , Hansen G.M. , Malm D. , Tranebjaerg L. , Tollersrud O.-K.
Hum. Mol. Genet.6:717-726(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);PARTIAL PROTEIN SEQUENCE;VARIANT MANSA LEU-72
tissue: Lung.
tissue: Skin.
3.

"Genomic structure of the human lysosomal alpha-mannosidase gene (MANB)."
Riise H.M.F. , Berg T. , Nilssen O. , Romeo G. , Tollersrud O.-K. , Ceccherini I.
Genomics42:200-207(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1)
4.

"The DNA sequence and biology of human chromosome 19."
Grimwood J. , Gordon L.A. , Olsen A.S. , Terry A. , Schmutz J. , Lamerdin J.E. , Hellsten U. , Goodstein D. , Couronne O. , Tran-Gyamfi M. , Aerts A. , Altherr M. , Ashworth L. , Bajorek E. , Black S. , Branscomb E. , Caenepeel S. , Carrano A.V. , more...
Nature428:529-535(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: Placenta.
7.

"Cloning, expression, purification, and characterization of the human broad specificity lysosomal acid alpha-mannosidase."
Liao Y.-F. , Lal A. , Moremen K.W.
J. Biol. Chem.271:28348-28358(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 9-1010 (ISOFORM 1)
tissue: Spleen.
8.

"Partial sequence of the purified protein confirms the identity of cDNA coding for human lysosomal alpha-mannosidase B."
Emiliani C. , Martino S. , Stirling J.L. , Maras B. , Orlacchio A.
Biochem. J.305:363-366(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PARTIAL PROTEIN SEQUENCE
9.

"Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry."
Zhang H. , Li X.-J. , Martin D.B. , Aebersold R.
Nat. Biotechnol.21:660-666(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION AT ASN-930
10.

"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
Chen R. , Jiang X. , Sun D. , Han G. , Wang F. , Ye M. , Wang L. , Zou H.
J. Proteome Res.8:651-661(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-367 AND ASN-766
tissue: Liver.
11.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
12.

"Missense and nonsense mutations in the lysosomal alpha-mannosidase gene (MANB) in severe and mild forms of alpha-mannosidosis."
Gotoda Y. , Wakamatsu N. , Kawai H. , Nishida Y. , Matsumoto T.
Am. J. Hum. Genet.63:1015-1024(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS MANSA LEU-72; ARG-356 AND TRP-750
13.

"Spectrum of mutations in alpha-mannosidosis."
Berg T. , Riise H.M.F. , Hansen G.M. , Malm D. , Tranebjaerg L. , Tollersrud O.-K. , Nilssen O.
Am. J. Hum. Genet.64:77-88(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS MANSA PRO-355; LYS-402; ARG-714 AND PRO-809;VARIANTS VAL-278; ILE-312; GLN-337 AND SER-413
14.

"Alpha-mannosidosis and mutational analysis in a Turkish patient."
Oelmez A. , Nilssen O. , Coskun T. , Klenow H.
Turk. J. Pediatr.45:46-50(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT MANSA TYR-453
15.

"Identification and characterization of five novel MAN2B1 mutations in Italian patients with alpha-mannosidosis."
Sbaragli M. , Bibi L. , Pittis M.G. , Balducci C. , Heikinheimo P. , Ricci R. , Antuzzi D. , Parini R. , Spaccini L. , Bembi B. , Beccari T.
Hum. Mutat.25:320-320(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS MANSA LEU-200 AND ASP-801;CHARACTERIZATION OF VARIANTS MANSA LEU-200 AND ASP-801
16.

"Identification of 83 novel alpha-mannosidosis-associated sequence variants: functional analysis of MAN2B1 missense mutations."
Riise Stensland H.M. , Klenow H.B. , Van Nguyen L. , Hansen G.M. , Malm D. , Nilssen O.
Hum. Mutat.33:511-520(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS MANSA PHE-55; GLU-74; PRO-95; HIS-99; ASN-159; ARG-197; ASN-200; LEU-200; PRO-202; TRP-229; LEU-263; LEU-318; 339-VAL--GLN-342 DEL; PRO-352; LEU-379; CYS-390; LYS-402; VAL-420; TYR-445; CYS-451; TYR-453; PHE-453; GLU-457; SER-501; PRO-565; ARG-745; ARG-800; TRP-800; HIS-ARG-815 INS; ARG-891; PRO-892; CYS-916; HIS-916; PRO-950; ARG-956 AND SER-1000;VARIANTS LEU-248; VAL-278; SER-282; ILE-312; GLN-337; SER-413; SER-481 AND LEU-669;CHARACTERIZATION OF VARIANTS MANSA PHE-55; GLU-74; PRO-95; HIS-99; ASN-159; ARG-197; ASN-200; LEU-200; PRO-202; TRP-229; LEU-263; LEU-318; PRO-352; LEU-379; CYS-390; LYS-402; VAL-420; TYR-445; CYS-451; TYR-453; PHE-453; GLU-457; SER-501; PRO-565; ARG-745; ARG-800; TRP-800; HIS-ARG-815 INS; ARG-891; PRO-892; CYS-916; HIS-916; PRO-950; ARG-956 AND SER-1000

Product Feedback Wall

* Email:
*Comments: