Protein name:
Protein maelstrom homolog ;
Alternative:
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Interacts with SMARCB1, SIN3B and DDX4. Interacts with piRNA-associated proteins TDRD1, PIWIL1 and PIWIL2.
Function:
Plays a central role during spermatogenesis by repressing transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Its association with piP-bodies suggests a participation in the secondary piRNAs metabolic process. Required for localization of germ-cell factors to the meiotic nuage.
Subcellular Location:
Cytoplasm
Nucleus
Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon during meiosis. Recruited to perinuclear nuage during spermatogenesis. Specifically localizes to piP-bodies, a subset of the nuage which contains secondary piRNAs. PIWIL2 is required for its localization to piP-bodies. PubMed:16787967, reported an association with the nuclear XY body, however, PubMed:18694567 showed that it is not the case because the antibody used by PubMed:16787967 still stains the nuclear XY body in spermatocytes lacking Mael. Moreover other antibodies raized against the same epitope used in PubMed:16787967 do not recognize any epitopes on XY chromosomes but show a clear localization to the meiotic nuage.
Protein Attributes:
50:
MPNRRASRNA | YYFFVQEKIP | ELRRRGLPVA | RVADAIPYCS | ADWALLREDE |
100:
KEKYSEMARE | WRAAQGKDSG | PSEKQKLVST | PLRRPGMLVP | KPSISPPDMS |
150:
NLSIKSDQAL | LGGIFYFLNI | FSHGELPPHC | EQRFLPCEIG | CVKYSLQEGI |
200:
MADFHSFIHP | GEIPRGFRFH | CQAASDSSHK | IPISNFEFGH | DQATVLQNLY |
250:
KFIHPNPGNW | PPIYCKSDDR | ARVNWCLKRM | ERASEIRQDL | ELLTVEDLVV |
300:
GIYQQKFLKE | PSKTWVRSLL | DVAMWDYSSN | TRCKWHEEND | ILFCALAVCK |
350:
KIAYCISNSL | ATLFGIQLTG | AHVPLQDYEA | SNSVTPKMVV | LDAGRYQKLR |
400:
VESPGFCHFN | SYNQEQRSNT | STGYYPSGVK | ISGPHSSVRG | RGITRLLESI |
434:
SNSSNNIHRF | SSCETSLSPY | TPQKDGYKPF | SSFS
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Bovine
Mouse
Pig
Human
ELISA Kit for Mouse Protein maelstrom homolog
ELISA Kit for Mouse Protein maelstrom homolog
ELISA Kit for Mouse Protein maelstrom homolog
ELISA Kit for Mouse Protein maelstrom homolog
CLIA Kit for Mouse Protein maelstrom homolog
CLIA Kit for Mouse Protein maelstrom homolog
CLIA Kit for Mouse Protein maelstrom homolog
CLIA Kit for Mouse Protein maelstrom homolog
Polyclonal Antibody for Mouse Protein maelstrom homolog
Polyclonal Antibody for Mouse Protein maelstrom homolog
Polyclonal Antibody for Mouse Protein maelstrom homolog
Polyclonal Antibody for Mouse Protein maelstrom homolog
Monoclonal Antibody for Mouse Protein maelstrom homolog
Monoclonal Antibody for Mouse Protein maelstrom homolog
Monoclonal Antibody for Mouse Protein maelstrom homolog
Monoclonal Antibody for Mouse Protein maelstrom homolog
Protein for Mouse Protein maelstrom homolog
Protein for Mouse Protein maelstrom homolog
Protein for Mouse Protein maelstrom homolog
Protein for Mouse Protein maelstrom homolog
R&D Technical Data
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Precision
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Recovery
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Linearity
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more...
Science309:1559-1563(2005)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain :
C57BL/6J .
tissue :
Testis .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue :
Testis .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SUBCELLULAR LOCATION;TISSUE SPECIFICITY;DEVELOPMENTAL STAGE;INTERACTION WITH SMARCB1; SIN3B; DDX4; PIWIL1; PIWIL2 AND TDRD1
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY;DISRUPTION PHENOTYPE
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;SUBCELLULAR LOCATION;DISRUPTION PHENOTYPE