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Index > Protein center > Mael(Gene name) > Mouse
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  • Mael (Gene name),
  • Protein maelstrom homolog (Protein name ),  MAEL_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Mael;
    Protein name:
    Protein maelstrom homolog;
    Alternative:

    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Interacts with SMARCB1, SIN3B and DDX4. Interacts with piRNA-associated proteins TDRD1, PIWIL1 and PIWIL2.
    Function:
    Plays a central role during spermatogenesis by repressing transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Its association with piP-bodies suggests a participation in the secondary piRNAs metabolic process. Required for localization of germ-cell factors to the meiotic nuage.
    Subcellular Location:
    Cytoplasm Nucleus Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon during meiosis. Recruited to perinuclear nuage during spermatogenesis. Specifically localizes to piP-bodies, a subset of the nuage which contains secondary piRNAs. PIWIL2 is required for its localization to piP-bodies. PubMed:16787967, reported an association with the nuclear XY body, however, PubMed:18694567 showed that it is not the case because the antibody used by PubMed:16787967 still stains the nuclear XY body in spermatocytes lacking Mael. Moreover other antibodies raized against the same epitope used in PubMed:16787967 do not recognize any epitopes on XY chromosomes but show a clear localization to the meiotic nuage.
    Protein Attributes:
    Sequence length:
    434
    Sequence:
    50:
    MPNRRASRNA | YYFFVQEKIP | ELRRRGLPVA | RVADAIPYCS | ADWALLREDE | 
    100:
    KEKYSEMARE | WRAAQGKDSG | PSEKQKLVST | PLRRPGMLVP | KPSISPPDMS | 
    150:
    NLSIKSDQAL | LGGIFYFLNI | FSHGELPPHC | EQRFLPCEIG | CVKYSLQEGI | 
    200:
    MADFHSFIHP | GEIPRGFRFH | CQAASDSSHK | IPISNFEFGH | DQATVLQNLY | 
    250:
    KFIHPNPGNW | PPIYCKSDDR | ARVNWCLKRM | ERASEIRQDL | ELLTVEDLVV | 
    300:
    GIYQQKFLKE | PSKTWVRSLL | DVAMWDYSSN | TRCKWHEEND | ILFCALAVCK | 
    350:
    KIAYCISNSL | ATLFGIQLTG | AHVPLQDYEA | SNSVTPKMVV | LDAGRYQKLR | 
    400:
    VESPGFCHFN | SYNQEQRSNT | STGYYPSGVK | ISGPHSSVRG | RGITRLLESI | 
    434:
    SNSSNNIHRF | SSCETSLSPY | TPQKDGYKPF | SSFS
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    KEGG:
    UniGene:
    String:
    Pfam:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Protein maelstrom homolog
    ELISA Kit for Mouse Protein maelstrom homolog
    ELISA Kit for Mouse Protein maelstrom homolog
    ELISA Kit for Mouse Protein maelstrom homolog
    CLIA Kit for Mouse Protein maelstrom homolog
    CLIA Kit for Mouse Protein maelstrom homolog
    CLIA Kit for Mouse Protein maelstrom homolog
    CLIA Kit for Mouse Protein maelstrom homolog
    Polyclonal Antibody for Mouse Protein maelstrom homolog
    Polyclonal Antibody for Mouse Protein maelstrom homolog
    Polyclonal Antibody for Mouse Protein maelstrom homolog
    Polyclonal Antibody for Mouse Protein maelstrom homolog
    Monoclonal Antibody for Mouse Protein maelstrom homolog
    Monoclonal Antibody for Mouse Protein maelstrom homolog
    Monoclonal Antibody for Mouse Protein maelstrom homolog
    Monoclonal Antibody for Mouse Protein maelstrom homolog
    Protein for Mouse Protein maelstrom homolog
    Protein for Mouse Protein maelstrom homolog
    Protein for Mouse Protein maelstrom homolog
    Protein for Mouse Protein maelstrom homolog

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    Linearity
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    References
    1. 1.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: C57BL/6J.
      tissue: Testis.
    2. 2.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Testis.
    3. 3.
      "Mouse MAELSTROM: the link between meiotic silencing of unsynapsed chromatin and microRNA pathway?"
      Costa Y. , Speed R.M. , Gautier P. , Semple C.A. , Maratou K. , Turner J.M.A. , Cooke H.J.
      Hum. Mol. Genet.15:2324-2334(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;TISSUE SPECIFICITY;DEVELOPMENTAL STAGE;INTERACTION WITH SMARCB1; SIN3B; DDX4; PIWIL1; PIWIL2 AND TDRD1
    4. 4.
      "Mouse maelstrom, a component of nuage, is essential for spermatogenesis and transposon repression in meiosis."
      Soper S.F.C. , van der Heijden G.W. , Hardiman T.C. , Goodheart M. , Martin S.L. , de Boer P. , Bortvin A.
      Dev. Cell15:285-297(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY;DISRUPTION PHENOTYPE
    5. 5.
      "Cytoplasmic compartmentalization of the fetal piRNA pathway in mice."
      Aravin A.A. , van der Heijden G.W. , Castaneda J. , Vagin V.V. , Hannon G.J. , Bortvin A.
      PLoS Genet.5:E1000764-E1000764(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;DISRUPTION PHENOTYPE
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