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Index > Protein center > Maged1(Gene name) > Rat
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  • Maged1 (Gene name),
  • Melanoma-associated antigen D1 (Protein name ),  MAGD1_RAT from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Gene name:
    Maged1(Nrage);
    Protein name:
    Melanoma-associated antigen D1;
    Alternative:
    Neurotrophin receptor-interacting MAGE homolog;MAGE-D1 antigen;Sertoli cell necdin-related gene protein 1(SNERG-1);
    Organism:
    Rat (Rattus norvegicus). 
    General Annotation
    Sub Unit:
    Interacts with DLX5, DLX7 and MSX2 and forms homomultimers (By similarity). Interacts with UNC5A.
    Function:
    Involved in the apoptotic response after nerve growth factor (NGF) binding in neuronal cells. Binds p75NTR and antagonizes its association with TrkA, inhibits cell cycle progression, and facilitates p75NTR-mediated apoptosis. May act as a regulator of the function of DLX family members.
    Subcellular Location:
    Cytoplasm Cell membrane Peripheral membrane protein Expression shifts from the cytoplasm to the plasma membrane upon stimulation with NGF.
    Protein Attributes:
    Sequence length:
    775
    Sequence:
    50:
    MAQKPDGGAG | LRGFQAEASV | EDSALLVQTL | MEAIQISEAP | PTSQATAAAS | 
    100:
    GPNASPQSSQ | PPTANEKADT | EVSAAAARPK | TGFKAQNTTT | KGPNDYSQAR | 
    150:
    NAKEMPKNQP | KVAFKSQNAT | SKGPHAASDF | SHAASTGKSA | AKKSEMAFKG | 
    200:
    QNTTTKAGPS | ATYNFTQSPS | ANEMTNNQPK | TAKAWNDTTK | IPGADAQTQN | 
    250:
    VNQAKMADVG | TSAGISETDG | AAAQTSADGS | QAQNVESRTI | IRGKRTRKIN | 
    300:
    NLNVEENSNG | DQRRASLASG | NWRSAPVPVT | TQNPPGAPPN | VLWQTPLAWQ | 
    350:
    NPSGWQNQTA | RQTPPARQSP | PARQTPSAWQ | NPVAWQNPVI | WPNPVIWQNP | 
    400:
    VIWPNPIVWP | GPIVWPNPMA | WQSTPGWQSP | PSWQAPPSWQ | SPQDWQGPPD | 
    450:
    WQLPPDWSMP | PDWSFPSDWP | FPPDWIPADW | PIPPDWQNLR | PSPNLRSSPN | 
    500:
    SRASQNQGPP | QPRDVALLQE | RANKLVKYLM | LKDYTKVPIK | RSEMLRDIIR | 
    550:
    EYTDVYPEII | ERACFVLEKK | FGIQLKEIDK | EEHLYILIST | PESLAGILGT | 
    600:
    TKDTPKLGLL | LVILGIIFMN | GNRATEAVLW | EALRKMGLRP | GVRHPLLGDL | 
    650:
    RKLLTYEFVK | QKYLDYRRVP | NSNPPEYEFL | WGLRSYHETS | KMKVLRFIAE | 
    700:
    VQKRDPRDWT | AQFMEAADEA | LDALDAAAAE | AEARAEARNR | MGIGDEAVSG | 
    750:
    PWSWDDIEFE | LLTWDEEGDF | GDPWSRIPFT | FWARYHQNAR | SRFPQAFTGP | 
    775:
    IIGPSGTATA | NFAANFGAIG | FFWVE
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    KEGG:
    Pfam:
    UniGene:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Rat Melanoma-associated antigen D1
    Cat.:
    E6073h
    Price:
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Rat Melanoma-associated antigen D1
    Cat.:
    E6073p
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Rat Melanoma-associated antigen D1
    Cat.:
    E6073r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Rat Melanoma-associated antigen D1
    Cat.:
    E6073m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Rat Melanoma-associated antigen D1
    Cat.:
    U6073h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Rat Melanoma-associated antigen D1
    Cat.:
    U6073p
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Rat Melanoma-associated antigen D1
    Cat.:
    U6073m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Rat Melanoma-associated antigen D1
    Cat.:
    U6073r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Rat Melanoma-associated antigen D1
    Cat.:
    P6073Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Rat Melanoma-associated antigen D1
    Cat.:
    P6073Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Rat Melanoma-associated antigen D1
    Polyclonal Antibody for Rat Melanoma-associated antigen D1
    Cat.:
    P6073Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Rat Melanoma-associated antigen D1
    Monoclonal Antibody for Rat Melanoma-associated antigen D1
    Monoclonal Antibody for Rat Melanoma-associated antigen D1
    Monoclonal Antibody for Rat Melanoma-associated antigen D1
    Protein for Rat Melanoma-associated antigen D1
    Protein for Rat Melanoma-associated antigen D1
    Protein for Rat Melanoma-associated antigen D1
    Protein for Rat Melanoma-associated antigen D1

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    References
    1. 1.
      "NRAGE, a novel MAGE protein, interacts with the p75 neurotrophin receptor and facilitates nerve growth factor dependent apoptosis."
      Salehi A.H. , Roux P.P. , Kubu C.J. , Zeindler C. , Bhakar A. , Tannis L.-L. , Verdi J.M. , Barker P.A.
      Neuron27:279-288(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION IN APOPTOSIS;INTERACTION WITH NGFR
      strain: Sprague-Dawley.
      tissue: Neural crest.
    2. 2.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Testis.
    3. 3.
      "A novel messenger ribonucleic acid homologous to human MAGE-D is strongly expressed in rat Sertoli cells and weakly in Leydig cells and is regulated by follitropin, lutropin, and prolactin."
      Hennuy B. , Reiter E. , Cornet A. , Bruyninx M. , Daukandt M. , Houssa P. , N'Guyen V.-H. , Closset J. , Hennen G.
      Endocrinology141:3821-3831(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 206-775
      tissue: Testis.
    4. 4.
      "Rattus norvegicus mRNA for SNERG-1 protein, partial CDS."
      Zhang C. , He F.
      Submitted (2000-06) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 178-775
    5. 5.
      "UNC5H1 induces apoptosis via its juxtamembrane region through an interaction with NRAGE."
      Williams M.E. , Strickland P. , Watanabe K. , Hinck L.
      J. Biol. Chem.278:17483-17490(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH UNC5A
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