Gene name:
MAGI1 (AIP3;BAIAP1;BAP1;TNRC19) ;
Protein name:
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 ;
Alternative:
BAI1-associated protein 1 (BAP-1) ;Atrophin-1-interacting protein 3 (AIP-3) ;Trinucleotide repeat-containing gene 19 protein ;Membrane-associated guanylate kinase inverted 1 (MAGI-1) ;WW domain-containing protein 3 (WWP3) ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts through its WW 2 domain with SYNPO and through its PDZ 5 domain with ACTN4. Interacts with cytoplasmic domain of BAI1. Interacts via its WW domains with DRPLA. Interacts with ESAM, LRP2 and CXADR. May interact with CTNNB1. Interacts through its PDZ 1 domain with NET1 (By similarity). Interacts with ACCN3 and AMOT. Interacts with FCHSD2. Interacts with IGSF5/JAM4 and through its PDZ 2 and 3 domains with NPHS1 forming a tripartite complex (By similarity). Interacts with DDN.
Function:
May play a role as scaffolding protein at cell-cell junctions. May regulate acid-induced ACCN3 currents by modulating its expression at the cell surface.
Subcellular Location:
Cell junction
tight junction
Cell membrane
Peripheral membrane protein
Localizes to epithelial cells tight junctions.
Protein Attributes:
50:
MSKVIQKKNH | WTSRVHECTV | KRGPQGELGV | TVLGGAEHGE | FPYVGAVAAV |
100:
EAAGLPGGGE | GPRLGEGELL | LEVQGVRVSG | LPRYDVLGVI | DSCKEAVTFK |
150:
AVRQGGRLNK | DLRHFLNQRF | QKGSPDHELQ | QTIRDNLYRH | AVPCTTRSPR |
200:
EGEVPGVDYN | FLTVKEFLDL | EQSGTLLEVG | TYEGNYYGTP | KPPSQPVSGK |
250:
VITTDALHSL | QSGSKQSTPK | RTKSYNDMQN | AGIVHAENEE | EDDVPEMNSS |
300:
FTADSGEQEE | HTLQETALPP | VNSSIIAAPI | TDPSQKFPQY | LPLSAEDNLG |
350:
PLPENWEMAY | TENGEVYFID | HNTKTTSWLD | PRCLNKQQKP | LEECEDDEGV |
400:
HTEELDSELE | LPAGWEKIED | PVYGIYYVDH | INRKTQYENP | VLEAKRKKQL |
450:
EQQQQQQQQQ | QQQQQQQQQQ | QTEEWTEDHS | ALVPPVIPNH | PPSNPEPARE |
500:
VPLQGKPFFT | RNPSELKGKF | IHTKLRKSSR | GFGFTVVGGD | EPDEFLQIKS |
550:
LVLDGPAALD | GKMETGDVIV | SVNDTCVLGH | THAQVVKIFQ | SIPIGASVDL |
600:
ELCRGYPLPF | DPDDPNTSLV | TSVAILDKEP | IIVNGQETYD | SPASHSSKTG |
650:
KVNGMKDARP | SSPADVASNS | SHGYPNDTVS | LASSIATQPE | LITVHIVKGP |
700:
MGFGFTIADS | PGGGGQRVKQ | IVDSPRCRGL | KEGDLIVEVN | KKNVQALTHN |
750:
QVVDMLVECP | KGSEVTLLVQ | RGGLPVPKKS | PKSQPLERKD | SQNSSQHSVS |
800:
SHRSLHTASP | SHSTQVLPEF | PPAEAQAPDQ | TDSSGQKKPD | PFKIWAQSRS |
850:
MYENRPMSPS | PASGLSKGER | EREINSTNFG | ECPIPDYQEQ | DIFLWRKETG |
900:
FGFRILGGNE | PGEPIYIGHI | VPLGAADTDG | RLRSGDELIC | VDGTPVIGKS |
950:
HQLVVQLMQQ | AAKQGHVNLT | VRRKVVFAVP | KTENEVPSPA | SSHHSSNQPA |
1000:
SLTEEKRTPQ | GSQNSLNTVS | SGSGSTSGIG | SGGGGGSGVV | STVVQPYDVE |
1050:
IRRGENEGFG | FVIVSSVSRP | EAGTTFAGNA | CVAMPHKIGR | IIEGSPADRC |
1100:
GKLKVGDRIL | AVNGCSITNK | SHSDIVNLIK | EAGNTVTLRI | IPGDESSNAT |
1150:
LLTNAEKIAT | ITTTHTPSQQ | GTQETRNTTK | PKQESQFEFK | APQATQEQDF |
1200:
YTVELERGAK | GFGFSLRGGR | EYNMDLYVLR | LAEDGPAERC | GKMRIGDEIL |
1250:
EINGETTKNM | KHSRAIELIK | NGGRRVRLFL | KRGDGSVPEY | DPSSDRHGPA |
1300:
TGPQGVPEVR | AGPDRRQHPS | LESSYPPDLH | KSSPHGEKRA | HARDPKGSRE |
1350:
YSRQPNEHHT | WNGTSRKPDS | GACRPKDRAP | EGRRDAQAER | AAAANGPKRR |
1400:
SPEKRREGTR | SADNTLERRE | KHEKRRDVSP | ERRRERSPTR | RRDGSPSRRR |
1450:
RSLERLLEQR | RSPERRRGGS | PERRAKSTDR | RRARSPERRR | ERSLDKRNRE |
1491:
DRASHREREE | ANLKQDAGRS | SRHPPEQRRR | PYKECSTDLS | I
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Rat
Human
ELISA Kit for Human Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1
ELISA Kit for Human Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1
ELISA Kit for Human Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1
CLIA Kit for Human Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1
CLIA Kit for Human Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1
CLIA Kit for Human Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1
Polyclonal Antibody for Human Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1
Polyclonal Antibody for Human Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1
Polyclonal Antibody for Human Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1
Monoclonal Antibody for Human Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1
Monoclonal Antibody for Human Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1
Monoclonal Antibody for Human Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1
Protein for Human Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1
Protein for Human Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1
Protein for Human Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1
R&D Technical Data
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Precision
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Recovery
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Linearity
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3)
tissue :
Brain .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH FCHSD2
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH ASIC3
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH AMOT
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH DDN
14.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-730; SER-741 AND SER-1361;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
15.
"Solution structure of WW domains from the human membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1. MAGI-1."
RIKEN structural genomics initiative (RSGI)
Submitted (2008-04) to the PDB data bank
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : STRUCTURE BY NMR OF 295-401