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Index > Protein center > Magi2(Gene name) > Mouse
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  • Magi2 (Gene name),
  • Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Protein name ),  MAGI2_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    Magi2(Acvrinp1;Aip1;Arip1);
    Protein name:
    Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2;
    Alternative:
    Atrophin-1-interacting protein 1(AIP-1);Activin receptor-interacting protein 1(Acvrip1);Membrane-associated guanylate kinase inverted 2(MAGI-2);
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Interacts (via its WW domains) with DRPLA (By similarity). Interacts (via its second PDZ domain) with PTEN (via unphosphorylated C-terminus); this interaction diminishes the degradation rate of PTEN (By similarity). Interacts (via guanylate kinase domain) with DLGAP1 (By similarity). Interacts (via the PDZ domains) with GRIN2A, GRID2 and NLGN1 (By similarity). Interacts with CTNND2, CTNNB1 and MAGUIN-1 (By similarity). Interacts with ACVR2A, SMAD2 and SMAD3. Part of a complex consisting of AIP1, ACVR2A, ACVR1B and SMAD3. May interact with HTR2A. Interacts with RAPGEF2 (By similarity). Identified in a complex with ACTN4, CASK, IQGAP1, NPHS1, SPTAN1 and SPTBN1 (By similarity). Interacts with DDN (By similarity). Interacts with IGSF9 and HTR4.
    Function:
    Seems to act as scaffold molecule at synaptic junctions by assembling neurotransmitter receptors and cell adhesion proteins. May play a role in regulating activin-mediated signaling in neuronal cells. Enhances the ability of PTEN to suppress AKT1 activation.
    Subcellular Location:
    Cell junction synapse synaptosome Cell membrane Peripheral membrane protein Membrane-associated in synaptosomes.
    Protein Attributes:
    Sequence length:
    1275
    Sequence:
    50:
    MSKSLKKKSH | WTSKVHESVI | GRNPEGQLGF | ELKGGAENGQ | FPYLGEVKPG | 
    100:
    KVAYESGSKL | VSEELLLEVN | ETPVAGLTIR | DVLAVIKHCK | DPLRLKCVKQ | 
    150:
    GGIVDKDLRH | YLNLRFQKGS | VDHELQQIIR | DNLYLRTVPC | TTRPHKEGEV | 
    200:
    PGVDYIFITV | EEFMELEKSG | ALLESGTYED | NYYGTPKPPA | EPAPLLNVTD | 
    250:
    QILPGATPSA | EGKRKRNKSV | TNMEKASIEP | PEEEEEERPV | VNGNGVVITP | 
    300:
    ESSEHEDKSA | GASGETPSQP | YPAPVYSQPE | ELKDQMDDTK | PTKPEENEDS | 
    350:
    DPLPDNWEMA | YTEKGEVYFI | DHNTKTTSWL | DPRLAKKAKP | PEECKENELP | 
    400:
    YGWEKIDDPI | YGTYYVDHIN | RRTQFENPVL | EAKRKLQQHN | MPHTELGAKP | 
    450:
    LQAPGFREKP | LFTRDASQLK | GTFLSTTLKK | SNMGFGFTII | GGDEPDEFLQ | 
    500:
    VKSVIPDGPA | AQDGKMETGD | VIVYINEVCV | LGHTHADVVK | LFQSVPIGQS | 
    550:
    VNLVLCRGYP | LPFDPEDPAN | SMVPPLAIME | RPPPVMVNGR | HNYETYLEYI | 
    600:
    SRTSQSVPDI | TDRPPHSLHS | MPADGQLDGT | YPPPVHDDNV | SMASSGATQA | 
    650:
    ELMTLTIVKG | AQGFGFTIAD | SPTGQRVKQI | LDIQGCPGLC | EGDLIVEINQ | 
    700:
    QNVQNLSHTE | VVDILKDCPV | GSETSLIIHR | GGFFSPWKTP | KPMMDRWENQ | 
    750:
    GSPQTSLSAP | AVPQNLPFPP | ALHRSSFPDS | TEAFDPRKPD | PYELYEKSRA | 
    800:
    IYESRQQVPP | RTSFRMDSSG | PDYKELDVHL | RRMESGFGFR | ILGGDEPGQP | 
    850:
    ILIGAVIAMG | SADRDGRLHP | GDELVYVDGI | PVAGKTHRYV | IDLMHHAARN | 
    900:
    GQVNLTVRRK | VLCGGEPCPE | NGRSPGSVST | HHSSPRSDYA | TYSNSNHAAP | 
    950:
    SSNASPPEGF | ASHSLQTSDV | VIHRKENEGF | GFVIISSLNR | PESGATITVP | 
    1000:
    HKIGRIIDGS | PADRCAKLKV | GDRILAVNGQ | SIINMPHADI | VKLIKDAGLS | 
    1050:
    VTLRIIPQEE | LNSPTSAPSS | EKQSPMAQQH | SPLAQQSPLA | QPSPATPNSP | 
    1100:
    VAQPAPPQPL | QLQGHENSYR | SEVKARQDVK | PDIRQPPFTD | YRQPPLDYRQ | 
    1150:
    PPGGDYSQPP | PLDYRQHSPD | TRQYPLSDYR | QPQDFDYFTV | DMEKGAKGFG | 
    1200:
    FSIRGGREYK | MDLYVLRLAE | DGPAIRNGRM | RVGDQIIEIN | GESTRDMTHA | 
    1250:
    RAIELIKSGG | RRVRLLLKRG | TGQVPEYGMV | PSSLSMCMKS | DKHGSPYFYL | 
    1275:
    LGHPKDTTNP | TPGVLPLPPP | QACRK
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    Pfam:
    UniGene:
    SMR:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2
    ELISA Kit for Mouse Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2
    ELISA Kit for Mouse Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2
    CLIA Kit for Mouse Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2
    CLIA Kit for Mouse Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2
    CLIA Kit for Mouse Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2
    Polyclonal Antibody for Mouse Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2
    Polyclonal Antibody for Mouse Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2
    Polyclonal Antibody for Mouse Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2
    Monoclonal Antibody for Mouse Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2
    Monoclonal Antibody for Mouse Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2
    Monoclonal Antibody for Mouse Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2
    Protein for Mouse Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2
    Protein for Mouse Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2
    Protein for Mouse Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Identification and characterization of a PDZ protein that interacts with activin types II receptors."
      Shoji H. , Tsuchida K. , Kishi H. , Yamakawa N. , Matsuzaki T. , Liu Z. , Nakamura T. , Sugino H.
      J. Biol. Chem.275:5485-5492(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2);INTERACTION WITH SMAD2; SMAD3 AND ACVR2A;IDENTIFICATION IN A COMPLEX WITH ACVR2A; ACVR1B AND SMAD3
      strain: ICR.
      tissue: Brain.
    2. 2.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4)
      strain: C57BL/6J.
      tissue: Brain.
      tissue: Spinal cord.
    3. 3.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      strain: C57BL/6.
      tissue: Brain.
    4. 4.
      "The serotonin 5-HT2A and 5-HT2C receptors interact with specific sets of PDZ proteins."
      Becamel C. , Gavarini S. , Chanrion B. , Alonso G. , Galeotti N. , Dumuis A. , Bockaert J. , Marin P.
      J. Biol. Chem.279:20257-20266(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HTR2A
    5. 5.
      "New sorting nexin (SNX27) and NHERF specifically interact with the 5-HT4a receptor splice variant: roles in receptor targeting."
      Joubert L. , Hanson B. , Barthet G. , Sebben M. , Claeysen S. , Hong W. , Marin P. , Dumuis A. , Bockaert J.
      J. Cell Sci.117:5367-5379(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HTR4
    6. 6.
      "The immunoglobulin family member dendrite arborization and synapse maturation 1 (Dasm1) controls excitatory synapse maturation."
      Shi S.-H. , Cheng T. , Jan L.Y. , Jan Y.-N.
      Proc. Natl. Acad. Sci. U.S.A.101:13346-13351(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH IGSF9
    7. 7.
      "Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain."
      Ballif B.A. , Carey G.R. , Sunyaev S.R. , Gygi S.P.
      J. Proteome Res.7:311-318(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-361 AND TYR-826;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Brain.
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