Gene name:
Magi2 (Acvrinp1;Aip1;Arip1) ;
Protein name:
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 ;
Alternative:
Atrophin-1-interacting protein 1 (AIP-1) ;Activin receptor-interacting protein 1 (Acvrip1) ;Membrane-associated guanylate kinase inverted 2 (MAGI-2) ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Interacts (via its WW domains) with DRPLA (By similarity). Interacts (via its second PDZ domain) with PTEN (via unphosphorylated C-terminus); this interaction diminishes the degradation rate of PTEN (By similarity). Interacts (via guanylate kinase domain) with DLGAP1 (By similarity). Interacts (via the PDZ domains) with GRIN2A, GRID2 and NLGN1 (By similarity). Interacts with CTNND2, CTNNB1 and MAGUIN-1 (By similarity). Interacts with ACVR2A, SMAD2 and SMAD3. Part of a complex consisting of AIP1, ACVR2A, ACVR1B and SMAD3. May interact with HTR2A. Interacts with RAPGEF2 (By similarity). Identified in a complex with ACTN4, CASK, IQGAP1, NPHS1, SPTAN1 and SPTBN1 (By similarity). Interacts with DDN (By similarity). Interacts with IGSF9 and HTR4.
Function:
Seems to act as scaffold molecule at synaptic junctions by assembling neurotransmitter receptors and cell adhesion proteins. May play a role in regulating activin-mediated signaling in neuronal cells. Enhances the ability of PTEN to suppress AKT1 activation.
Subcellular Location:
Cell junction
synapse
synaptosome
Cell membrane
Peripheral membrane protein
Membrane-associated in synaptosomes.
Protein Attributes:
50:
MSKSLKKKSH | WTSKVHESVI | GRNPEGQLGF | ELKGGAENGQ | FPYLGEVKPG |
100:
KVAYESGSKL | VSEELLLEVN | ETPVAGLTIR | DVLAVIKHCK | DPLRLKCVKQ |
150:
GGIVDKDLRH | YLNLRFQKGS | VDHELQQIIR | DNLYLRTVPC | TTRPHKEGEV |
200:
PGVDYIFITV | EEFMELEKSG | ALLESGTYED | NYYGTPKPPA | EPAPLLNVTD |
250:
QILPGATPSA | EGKRKRNKSV | TNMEKASIEP | PEEEEEERPV | VNGNGVVITP |
300:
ESSEHEDKSA | GASGETPSQP | YPAPVYSQPE | ELKDQMDDTK | PTKPEENEDS |
350:
DPLPDNWEMA | YTEKGEVYFI | DHNTKTTSWL | DPRLAKKAKP | PEECKENELP |
400:
YGWEKIDDPI | YGTYYVDHIN | RRTQFENPVL | EAKRKLQQHN | MPHTELGAKP |
450:
LQAPGFREKP | LFTRDASQLK | GTFLSTTLKK | SNMGFGFTII | GGDEPDEFLQ |
500:
VKSVIPDGPA | AQDGKMETGD | VIVYINEVCV | LGHTHADVVK | LFQSVPIGQS |
550:
VNLVLCRGYP | LPFDPEDPAN | SMVPPLAIME | RPPPVMVNGR | HNYETYLEYI |
600:
SRTSQSVPDI | TDRPPHSLHS | MPADGQLDGT | YPPPVHDDNV | SMASSGATQA |
650:
ELMTLTIVKG | AQGFGFTIAD | SPTGQRVKQI | LDIQGCPGLC | EGDLIVEINQ |
700:
QNVQNLSHTE | VVDILKDCPV | GSETSLIIHR | GGFFSPWKTP | KPMMDRWENQ |
750:
GSPQTSLSAP | AVPQNLPFPP | ALHRSSFPDS | TEAFDPRKPD | PYELYEKSRA |
800:
IYESRQQVPP | RTSFRMDSSG | PDYKELDVHL | RRMESGFGFR | ILGGDEPGQP |
850:
ILIGAVIAMG | SADRDGRLHP | GDELVYVDGI | PVAGKTHRYV | IDLMHHAARN |
900:
GQVNLTVRRK | VLCGGEPCPE | NGRSPGSVST | HHSSPRSDYA | TYSNSNHAAP |
950:
SSNASPPEGF | ASHSLQTSDV | VIHRKENEGF | GFVIISSLNR | PESGATITVP |
1000:
HKIGRIIDGS | PADRCAKLKV | GDRILAVNGQ | SIINMPHADI | VKLIKDAGLS |
1050:
VTLRIIPQEE | LNSPTSAPSS | EKQSPMAQQH | SPLAQQSPLA | QPSPATPNSP |
1100:
VAQPAPPQPL | QLQGHENSYR | SEVKARQDVK | PDIRQPPFTD | YRQPPLDYRQ |
1150:
PPGGDYSQPP | PLDYRQHSPD | TRQYPLSDYR | QPQDFDYFTV | DMEKGAKGFG |
1200:
FSIRGGREYK | MDLYVLRLAE | DGPAIRNGRM | RVGDQIIEIN | GESTRDMTHA |
1250:
RAIELIKSGG | RRVRLLLKRG | TGQVPEYGMV | PSSLSMCMKS | DKHGSPYFYL |
1275:
LGHPKDTTNP | TPGVLPLPPP | QACRK
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Rat
Mouse
Human
ELISA Kit for Mouse Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2
ELISA Kit for Mouse Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2
ELISA Kit for Mouse Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2
CLIA Kit for Mouse Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2
CLIA Kit for Mouse Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2
CLIA Kit for Mouse Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2
Polyclonal Antibody for Mouse Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2
Polyclonal Antibody for Mouse Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2
Polyclonal Antibody for Mouse Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2
Monoclonal Antibody for Mouse Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2
Monoclonal Antibody for Mouse Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2
Monoclonal Antibody for Mouse Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2
Protein for Mouse Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2
Protein for Mouse Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2
Protein for Mouse Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2
R&D Technical Data
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Precision
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Recovery
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Linearity
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2);INTERACTION WITH SMAD2; SMAD3 AND ACVR2A;IDENTIFICATION IN A COMPLEX WITH ACVR2A; ACVR1B AND SMAD3
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ICR .
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Brain .
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Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4)
strain :
C57BL/6J .
tissue :
Brain .
tissue :
Spinal cord .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
strain :
C57BL/6 .
tissue :
Brain .
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH HTR2A
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH HTR4
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH IGSF9
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-361 AND TYR-826;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Brain .