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Index > Protein center > METAP1(Gene name) > Human
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  • METAP1 (Gene name),
  • Methionine aminopeptidase 1 (Protein name ),  MAP11_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Related Databases
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  • Gene name:
    METAP1(KIAA0094);
    Protein name:
    Methionine aminopeptidase 1(MAP 1);
    Alternative:
    Peptidase M 1;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Associates with the 60S ribosomal subunit of the 80S translational complex.
    Function:
    Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Required for normal progression through the cell cycle.
    Subcellular Location:
    Cytoplasm
    Protein Attributes:
    Sequence length:
    386
    Sequence:
    50:
    MAAVETRVCE | TDGCSSEAKL | QCPTCIKLGI | QGSYFCSQEC | FKGSWATHKL | 
    100:
    LHKKAKDEKA | KREVSSWTVE | GDINTDPWAG | YRYTGKLRPH | YPLMPTRPVP | 
    150:
    SYIQRPDYAD | HPLGMSESEQ | ALKGTSQIKL | LSSEDIEGMR | LVCRLAREVL | 
    200:
    DVAAGMIKPG | VTTEEIDHAV | HLACIARNCY | PSPLNYYNFP | KSCCTSVNEV | 
    250:
    ICHGIPDRRP | LQEGDIVNVD | ITLYRNGYHG | DLNETFFVGE | VDDGARKLVQ | 
    300:
    TTYECLMQAI | DAVKPGVRYR | ELGNIIQKHA | QANGFSVVRS | YCGHGIHKLF | 
    350:
    HTAPNVPHYA | KNKAVGVMKS | GHVFTIEPMI | CEGGWQDETW | PDGWTAVTRD | 
    386:
    GKRSAQFEHT | LLVTDTGCEI | LTRRLDSARP | HFMSQF
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    SMR:
    MIM:
    Pfam:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human MAP 1
    ELISA Kit for Human MAP 1
    ELISA Kit for Human MAP 1
    ELISA Kit for Human MAP 1
    ELISA Kit for Human MAP 1
    ELISA Kit for Human MAP 1
    ELISA Kit for Human MAP 1
    ELISA Kit for Human MAP 1
    CLIA Kit for Human MAP 1
    CLIA Kit for Human MAP 1
    CLIA Kit for Human MAP 1
    CLIA Kit for Human MAP 1
    CLIA Kit for Human MAP 1
    CLIA Kit for Human MAP 1
    CLIA Kit for Human MAP 1
    CLIA Kit for Human MAP 1
    Polyclonal Antibody for Human MAP 1
    Polyclonal Antibody for Human MAP 1
    Polyclonal Antibody for Human MAP 1
    Polyclonal Antibody for Human MAP 1
    Polyclonal Antibody for Human MAP 1
    Polyclonal Antibody for Human MAP 1
    Polyclonal Antibody for Human MAP 1
    Polyclonal Antibody for Human MAP 1
    Monoclonal Antibody for Human MAP 1
    Monoclonal Antibody for Human MAP 1
    Monoclonal Antibody for Human MAP 1
    Monoclonal Antibody for Human MAP 1
    Monoclonal Antibody for Human MAP 1
    Monoclonal Antibody for Human MAP 1
    Monoclonal Antibody for Human MAP 1
    Monoclonal Antibody for Human MAP 1
    Protein for Human MAP 1
    Protein for Human MAP 1
    Protein for Human MAP 1
    Protein for Human MAP 1
    Protein for Human MAP 1
    Protein for Human MAP 1
    Protein for Human MAP 1
    Protein for Human MAP 1

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    References
    1. 1.
      "Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1."
      Nagase T. , Miyajima N. , Tanaka A. , Sazuka T. , Seki N. , Sato S. , Tabata S. , Ishikawa K. , Kawarabayasi Y. , Kotani H. , Nomura N.
      DNA Res.2:37-43(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Bone marrow.
    2. 2.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Trachea.
    3. 3.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 110-386
      tissue: Placenta.
    5. 5.
      "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
      Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS];CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS]
    6. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    7. 7.
      "Structural basis for the functional differences between type I and type II human methionine aminopeptidases."
      Addlagatta A. , Hu X. , Liu J.O. , Matthews B.W.
      Biochemistry44:14741-14749(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.1 ANGSTROMS) OF 81-384 IN COMPLEX WITH COBALT IONS;FUNCTION;COFACTOR
    8. 8.
      "Identification of pyridinylpyrimidines as inhibitors of human methionine aminopeptidases."
      Hu X. , Addlagatta A. , Matthews B.W. , Liu J.O.
      Angew. Chem. Int. Ed.45:3772-3775(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 81-384 IN COMPLEX WITH COBALT IONS AND INHIBITORS
    9. 9.
      "Elucidation of the function of type 1 human methionine aminopeptidase during cell cycle progression."
      Hu X. , Addlagatta A. , Lu J. , Matthews B.W. , Liu J.O.
      Proc. Natl. Acad. Sci. U.S.A.103:18148-18153(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.5 ANGSTROMS) OF 81-384 IN COMPLEX WITH COBALT IONS AND INHIBITORS;CATALYTIC ACTIVITY;FUNCTION
    10. 10.
      "Structure of the angiogenesis inhibitor ovalicin bound to its noncognate target, human Type 1 methionine aminopeptidase."
      Addlagatta A. , Matthews B.W.
      Protein Sci.15:1842-1848(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.1 ANGSTROMS) OF 81-384 IN COMPLEX WITH COBALT IONS AND THE INHIBITOR OVALICIN
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