Mapkapk2 ELISA Kit for Mouse(Mus musculus) | EIAab.comMapkapk2 ELISA Kit for Mouse(Mus musculus)

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Mapkapk2 (Gene name),

MAP kinase-activated protein kinase 2 (Protein name ), MAPK2_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Mapkapk2(Rps6kc1);

Protein name:

MAP kinase-activated protein kinase 2(MAPK-activated protein kinase 2;MAPKAP kinase 2;MAPKAPK-2;MK2);

Alternative:

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Interacts with PHC2.

Function:

Its physiological substrate seems to be the small heat shock protein (HSP27/HSP25). In vitro can phosphorylate glycogen synthase at 'Ser-7' and tyrosine hydroxylase (on 'Ser-19' and 'Ser-40'). This kinase phosphorylates Ser in the peptide sequence, Hyd-X-R-X(2)-S, where Hyd is a large hydrophobic residue. Mediates both ERK and p38 MAPK/MAPK14 dependent neutrophil responses. Participates in TNF alpha-stimulated exocytosis of secretory vesicles in neutrophils. Plays a role in phagocytosis-induced respiratory burst activity.

Subcellular Location:

N/A

Protein Attributes:

Sequence length:

386

Sequence:

50:

100:

150:

200:

250:

300:

350:

386:

VDYEQIKIKK | IEDASNPLLL | KRRKKARAVE | DAALAH

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

KEGG:

mmu:17164

SMR:

P49138

UniGene:

Mm.221235

Pfam:

PF00069

String:

P49138

Uniprot:

P49138

FOR

ELISA Kit for Mouse MAPK-activated protein kinase 2

CLIA Kit for Mouse MAPK-activated protein kinase 2

Polyclonal Antibody for Mouse MAPK-activated protein kinase 2

Monoclonal Antibody for Mouse MAPK-activated protein kinase 2

Protein for Mouse MAPK-activated protein kinase 2

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"The MAP kinase-activated protein kinase 2 contains a proline-rich SH3-binding domain."
Engel K. , Plath K. , Gaestel M.
FEBS Lett.336:143-147(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2-386
tissue: Lung.
2.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain: C57BL/6.
tissue: Brain.
3.

"Small heat shock proteins are molecular chaperones."
Jakob U. , Gaestel M. , Engel K. , Buchner J.
J. Biol. Chem.268:1517-1520(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF HSPB1
4.

"Constitutive activation of mitogen-activated protein kinase-activated protein kinase 2 by mutation of phosphorylation sites and an A-helix motif."
Engel K. , Schultz H. , Martin F. , Kotlyarov A. , Plath K. , Hahn M. , Heinemann U. , Gaestel M.
J. Biol. Chem.270:27213-27221(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;PHOSPHORYLATION AT THR-208 AND THR-320;MUTAGENESIS OF THR-208; THR-320; LYS-329 AND TRP-335
5.

"MAPKAP kinase 2 is essential for LPS-induced TNF-alpha biosynthesis."
Kotlyarov A. , Neininger A. , Schubert C. , Eckert R. , Birchmeier C. , Volk H.D. , Gaestel M.
Nat. Cell Biol.1:94-97(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DISRUPTION PHENOTYPE
6.

"Leptomycin B-sensitive nuclear export of MAPKAP kinase 2 is regulated by phosphorylation."
Engel K. , Kotlyarov A. , Gaestel M.
EMBO J.17:3363-3371(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;PHOSPHORYLATION AT THR-208 AND THR-320;NUCLEAR EXPORT SIGNAL (NES)
7.

"Inhibition of SAPK2a/p38 prevents hnRNP A0 phosphorylation by MAPKAP-K2 and its interaction with cytokine mRNAs."
Rousseau S. , Morrice N. , Peggie M. , Campbell D.G. , Gaestel M. , Cohen P.
EMBO J.21:6505-6514(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF HNRNPA0
8.

"Distinct cellular functions of MK2."
Kotlyarov A. , Yannoni Y. , Fritz S. , Laass K. , Telliez J.B. , Pitman D. , Lin L.L. , Gaestel M.
Mol. Cell. Biol.22:4827-4835(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE
9.

"MAPKAP kinase 2 phosphorylates tristetraprolin on in vivo sites including Ser178, a site required for 14-3-3 binding."
Chrestensen C.A. , Schroeder M.J. , Shabanowitz J. , Hunt D.F. , Pelo J.W. , Worthington M.T. , Sturgill T.W.
J. Biol. Chem.279:10176-10184(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF ZFP36
10.

"The phosphorylation of CapZ-interacting protein (CapZIP) by stress-activated protein kinases triggers its dissociation from CapZ."
Eyers C.E. , McNeill H. , Knebel A. , Morrice N. , Arthur S.J.C. , Cuenda A. , Cohen P.
Biochem. J.389:127-135(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF RCSD1
11.

"The mitogen-activated protein kinase (MAPK)-activated protein kinases MK2 and MK3 cooperate in stimulation of tumor necrosis factor biosynthesis and stabilization of p38 MAPK."
Ronkina N. , Kotlyarov A. , Dittrich-Breiholz O. , Kracht M. , Hitti E. , Milarski K. , Askew R. , Marusic S. , Lin L.L. , Gaestel M. , Telliez J.B.
Mol. Cell. Biol.27:170-181(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE;TISSUE SPECIFICITY
12.

"The MAPK-activated kinase Rsk controls an acute Toll-like receptor signaling response in dendritic cells and is activated through two distinct pathways."
Zaru R. , Ronkina N. , Gaestel M. , Arthur J.S. , Watts C.
Nat. Immunol.8:1227-1235(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF RPS6KA3
13.

"Large-scale phosphorylation analysis of mouse liver."
Villen J. , Beausoleil S.A. , Gerber S.A. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Liver.
14.

"p38 MAP kinase and MAPKAP kinases MK2/3 cooperatively phosphorylate epithelial keratins."
Menon M.B. , Schwermann J. , Singh A.K. , Franz-Wachtel M. , Pabst O. , Seidler U. , Omary M.B. , Kotlyarov A. , Gaestel M.
J. Biol. Chem.285:33242-33251(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF KRT18 AND KRT20
15.

"Phosphorylation of cAMP-specific PDE4A5 (phosphodiesterase-4A5) by MK2 (MAPKAPK2) attenuates its activation through protein kinase A phosphorylation."
MacKenzie K.F. , Wallace D.A. , Hill E.V. , Anthony D.F. , Henderson D.J. , Houslay D.M. , Arthur J.S. , Baillie G.S. , Houslay M.D.
Biochem. J.435:755-769(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF PDE4A

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