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Index > Protein center > MARCH2(Gene name) > Human
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  • MARCH2 (Gene name),
  • E3 ubiquitin-protein ligase MARCH2 (Protein name ),  MARH2_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    MARCH2(HSPC240;RNF172);
    Protein name:
    E3 ubiquitin-protein ligase MARCH2;
    Alternative:
    Membrane-associated RING-CH protein II(MARCH-II);Membrane-associated RING finger protein 2;RING finger protein 172;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with STX6 (By similarity). Interacts with MARCH3.
    Function:
    E3 ubiquitin-protein ligase that may mediate ubiquitination of TFRC and CD86, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May be involved in endosomal trafficking through interaction with STX6.
    Subcellular Location:
    Endoplasmic reticulum membrane Multi-pass membrane protein Lysosome membrane Multi-pass membrane protein Endosome membrane Multi-pass membrane protein
    Protein Attributes:
    Sequence length:
    246
    Sequence:
    50:
    MTTGDCCHLP | GSLCDCSGSP | AFSKVVEATG | LGPPQYVAQV | TSRDGRLLST | 
    100:
    VIRALDTPSD | GPFCRICHEG | ANGECLLSPC | GCTGTLGAVH | KSCLEKWLSS | 
    150:
    SNTSYCELCH | TEFAVEKRPR | PLTEWLKDPG | PRTEKRTLCC | DMVCFLFITP | 
    200:
    LAAISGWLCL | RGAQDHLRLH | SQLEAVGLIA | LTIALFTIYV | LWTLVSFRYH | 
    246:
    CQLYSEWRKT | NQKVRLKIRE | ADSPEGPQHS | PLAAGLLKKV | AEETPV
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    UniGene:
    KEGG:
    MIM:
    SMR:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Human E3 ubiquitin-protein ligase MARCH2
    ELISA Kit for Human E3 ubiquitin-protein ligase MARCH2
    ELISA Kit for Human E3 ubiquitin-protein ligase MARCH2
    ELISA Kit for Human E3 ubiquitin-protein ligase MARCH2
    CLIA Kit for Human E3 ubiquitin-protein ligase MARCH2
    CLIA Kit for Human E3 ubiquitin-protein ligase MARCH2
    CLIA Kit for Human E3 ubiquitin-protein ligase MARCH2
    CLIA Kit for Human E3 ubiquitin-protein ligase MARCH2
    Polyclonal Antibody for Human E3 ubiquitin-protein ligase MARCH2
    Polyclonal Antibody for Human E3 ubiquitin-protein ligase MARCH2
    Polyclonal Antibody for Human E3 ubiquitin-protein ligase MARCH2
    Polyclonal Antibody for Human E3 ubiquitin-protein ligase MARCH2
    Monoclonal Antibody for Human E3 ubiquitin-protein ligase MARCH2
    Monoclonal Antibody for Human E3 ubiquitin-protein ligase MARCH2
    Monoclonal Antibody for Human E3 ubiquitin-protein ligase MARCH2
    Monoclonal Antibody for Human E3 ubiquitin-protein ligase MARCH2
    Protein for Human E3 ubiquitin-protein ligase MARCH2
    Protein for Human E3 ubiquitin-protein ligase MARCH2
    Protein for Human E3 ubiquitin-protein ligase MARCH2
    Protein for Human E3 ubiquitin-protein ligase MARCH2

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    References
    1. 1.
      "MARCH-II is a syntaxin-6-binding protein involved in endosomal trafficking."
      Nakamura N. , Fukuda H. , Kato A. , Hirose S.
      Mol. Biol. Cell16:1696-1710(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION
    2. 2.
      "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
      Zhang Q.-H. , Ye M. , Wu X.-Y. , Ren S.-X. , Zhao M. , Zhao C.-J. , Fu G. , Shen Y. , Fan H.-Y. , Lu G. , Zhong M. , Xu X.-R. , Han Z.-G. , Zhang J.-W. , Tao J. , Huang Q.-H. , Zhou J. , Hu G.-X. , more...
      Genome Res.10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Umbilical cord blood.
    3. 3.
      "The DNA sequence and biology of human chromosome 19."
      Grimwood J. , Gordon L.A. , Olsen A.S. , Terry A. , Schmutz J. , Lamerdin J.E. , Hellsten U. , Goodstein D. , Couronne O. , Tran-Gyamfi M. , Aerts A. , Altherr M. , Ashworth L. , Bajorek E. , Black S. , Branscomb E. , Caenepeel S. , Carrano A.V. , more...
      Nature428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT THR-54
      tissue: Brain.
      tissue: Skin.
    5. 5.
      "Downregulation of major histocompatibility complex class I by human ubiquitin ligases related to viral immune evasion proteins."
      Bartee E. , Mansouri M. , Hovey Nerenberg B.T. , Gouveia K. , Frueh K.
      J. Virol.78:1109-1120(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY;SUBCELLULAR LOCATION
    6. 6.
      "MARCH-III is a novel component of endosomes with properties similar to those of MARCH-II."
      Fukuda H. , Nakamura N. , Hirose S.
      J. Biochem.139:137-145(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH MARCH3
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