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Index > Protein center > MARCH5(Gene name) > Human
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  • MARCH5 (Gene name),
  • E3 ubiquitin-protein ligase MARCH5 (Protein name ),  MARH5_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    MARCH5(RNF153);
    Protein name:
    E3 ubiquitin-protein ligase MARCH5;
    Alternative:
    Membrane-associated RING-CH protein V(MARCH-V);Membrane-associated RING finger protein 5;RING finger protein 153;Mitochondrial ubiquitin ligase(MITOL);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Monomer and homodimer. Interacts with MFN1, MFN2, DNM1L and FIS1.
    Function:
    Mitochondrial E3 ubiquitin-protein ligase that plays a crucial role in the control of mitochondrial morphology by acting as a positive regulator of mitochondrial fission. May play a role in the prevention of cell senescence acting as a regulator of mitochondrial quality control. Promotes ubiquitination of FIS1, DNM1L and MFN1.
    Subcellular Location:
    Mitochondrion outer membrane Multi-pass membrane protein Endoplasmic reticulum membrane Authors show that the protein can be detected in endoplasmic reticulum (PubMed:14722266). Authors (PubMed:16874301) show its presence only in mitochondria.
    Protein Attributes:
    Sequence length:
    278
    Sequence:
    50:
    MPDQALQQML | DRSCWVCFAT | DEDDRTAEWV | RPCRCRGSTK | WVHQACLQRW | 
    100:
    VDEKQRGNST | ARVACPQCNA | EYLIVFPKLG | PVVYVLDLAD | RLISKACPFA | 
    150:
    AAGIMVGSIY | WTAVTYGAVT | VMQVVGHKEG | LDVMERADPL | FLLIGLPTIP | 
    200:
    VMLILGKMIR | WEDYVLRLWR | KYSNKLQILN | SIFPGIGCPV | PRIPAEANPL | 
    250:
    ADHVSATRIL | CGALVFPTIA | TIVGKLMFSS | VNSNLQRTIL | GGIAFVAIKG | 
    278:
    AFKVYFKQQQ | YLRQAHRKIL | NYPEQEEA
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    KEGG:
    UniGene:
    String:
    MIM:
    SMR:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Human E3 ubiquitin-protein ligase MARCH5
    ELISA Kit for Human E3 ubiquitin-protein ligase MARCH5
    ELISA Kit for Human E3 ubiquitin-protein ligase MARCH5
    ELISA Kit for Human E3 ubiquitin-protein ligase MARCH5
    CLIA Kit for Human E3 ubiquitin-protein ligase MARCH5
    CLIA Kit for Human E3 ubiquitin-protein ligase MARCH5
    CLIA Kit for Human E3 ubiquitin-protein ligase MARCH5
    CLIA Kit for Human E3 ubiquitin-protein ligase MARCH5
    Polyclonal Antibody for Human E3 ubiquitin-protein ligase MARCH5
    Polyclonal Antibody for Human E3 ubiquitin-protein ligase MARCH5
    Polyclonal Antibody for Human E3 ubiquitin-protein ligase MARCH5
    Polyclonal Antibody for Human E3 ubiquitin-protein ligase MARCH5
    Monoclonal Antibody for Human E3 ubiquitin-protein ligase MARCH5
    Monoclonal Antibody for Human E3 ubiquitin-protein ligase MARCH5
    Monoclonal Antibody for Human E3 ubiquitin-protein ligase MARCH5
    Monoclonal Antibody for Human E3 ubiquitin-protein ligase MARCH5
    Protein for Human E3 ubiquitin-protein ligase MARCH5
    Protein for Human E3 ubiquitin-protein ligase MARCH5
    Protein for Human E3 ubiquitin-protein ligase MARCH5
    Protein for Human E3 ubiquitin-protein ligase MARCH5

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    Precision
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    Linearity
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    References
    1. 1.
      "MARCH-V is a novel mitofusin 2- and Drp1-binding protein able to change mitochondrial morphology."
      Nakamura N. , Kimura Y. , Tokuda M. , Honda S. , Hirose S.
      EMBO Rep.7:1019-1022(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];INTERACTION WITH MFN2 AND DNM1L;SUBCELLULAR LOCATION
    2. 2.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    3. 3.
      "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P. , Earthrowl M.E. , Grafham D.V. , Rubenfield M. , French L. , Steward C.A. , Sims S.K. , Jones M.C. , Searle S. , Scott C. , Howe K. , Hunt S.E. , Andrews T.D. , Gilbert J.G.R. , Swarbreck D. , Ashurst J.L. , Taylor A. , Battles J. , more...
      Nature429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Uterus.
    5. 5.
      "Downregulation of major histocompatibility complex class I by human ubiquitin ligases related to viral immune evasion proteins."
      Bartee E. , Mansouri M. , Hovey Nerenberg B.T. , Gouveia K. , Frueh K.
      J. Virol.78:1109-1120(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
    6. 6.
      "A novel mitochondrial ubiquitin ligase plays a critical role in mitochondrial dynamics."
      Yonashiro R. , Ishido S. , Kyo S. , Fukuda T. , Goto E. , Matsuki Y. , Ohmura-Hoshino M. , Sada K. , Hotta H. , Yamamura H. , Inatome R. , Yanagi S.
      EMBO J.25:3618-3626(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION AS AN E3 UBIQUITIN LIGASE FOR FIS1 AND DNM1L AND AS A REGULATOR OF MITOCHONDRIAL FISSION;AUTOUBIQUITINATION;PTM;SUBCELLULAR LOCATION;INTERACTION WITH FIS1 AND DNM1L;TISSUE SPECIFICITY;MUTAGENESIS OF CYS-65 AND CYS-68
    7. 7.
      "The mitochondrial E3 ubiquitin ligase MARCH5 is required for Drp1 dependent mitochondrial division."
      Karbowski M. , Neutzner A. , Youle R.J.
      J. Cell Biol.178:71-84(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION AS A REGULATOR OF MITOCHONDRIAL MORPHOLOGY;MUTAGENESIS OF HIS-43; CYS-65 AND CYS-68;SUBUNIT;SUBCELLULAR LOCATION
    8. 8.
      "Mitochondrial ubiquitin ligase MITOL ubiquitinates mutant SOD1 and attenuates mutant SOD1-induced reactive oxygen species generation."
      Yonashiro R. , Sugiura A. , Miyachi M. , Fukuda T. , Matsushita N. , Inatome R. , Ogata Y. , Suzuki T. , Dohmae N. , Yanagi S.
      Mol. Biol. Cell20:4524-4530(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION AS A REGULATOR OF MITOCHONDRIAL QUALITY CONTROL;SUBCELLULAR LOCATION
    9. 9.
      "Loss of MARCH5 mitochondrial E3 ubiquitin ligase induces cellular senescence through dynamin-related protein 1 and mitofusin 1."
      Park Y.Y. , Lee S. , Karbowski M. , Neutzner A. , Youle R.J. , Cho H.
      J. Cell Sci.123:619-626(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION AS AN E3 UBIQUITIN LIGASE FOR MFN1 AND AS A POSITIVE REGULATOR OF MITOCHONDRIAL FISSION;MUTAGENESIS OF HIS-43;INTERACTION WITH MFN1
    10. 10.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    11. 11.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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