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Index > Protein center > MAS1(Gene name) > Human
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  • MAS1 (Gene name),
  • Proto-oncogene Mas (Protein name ),  MAS_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    MAS1(MAS);
    Protein name:
    Proto-oncogene Mas;
    Alternative:

    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with AGTR1.
    Function:
    Receptor for angiotensin 1-7 (By similarity). Acts specifically as a functional antagonist of AGTR1 (angiotensin-2 type 1 receptor), although it up-regulates AGTR1 receptor levels. Positive regulation of AGTR1 levels occurs through activation of the G-proteins GNA11 and GNAQ, and stimulation of the protein kinase C signaling cascade. The antagonist effect on AGTR1 function is probably due to AGTR1 being physically altered by MAS1.
    Subcellular Location:
    Cell membrane Multi-pass membrane protein
    Protein Attributes:
    Sequence length:
    325
    Sequence:
    50:
    MDGSNVTSFV | VEEPTNISTG | RNASVGNAHR | QIPIVHWVIM | SISPVGFVEN | 
    100:
    GILLWFLCFR | MRRNPFTVYI | THLSIADISL | LFCIFILSID | YALDYELSSG | 
    150:
    HYYTIVTLSV | TFLFGYNTGL | YLLTAISVER | CLSVLYPIWY | RCHRPKYQSA | 
    200:
    LVCALLWALS | CLVTTMEYVM | CIDREEESHS | RNDCRAVIIF | IAILSFLVFT | 
    250:
    PLMLVSSTIL | VVKIRKNTWA | SHSSKLYIVI | MVTIIIFLIF | AMPMRLLYLL | 
    300:
    YYEYWSTFGN | LHHISLLFST | INSSANPFIY | FFVGSSKKKR | FKESLKVVLT | 
    325:
    RAFKDEMQPR | RQKDNCNTVT | VETVV
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    SMR:
    KEGG:
    Pfam:
    MIM:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Human Proto-oncogene Mas
    Cat.:
    E13495h
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human Proto-oncogene Mas
    Cat.:
    E13495m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Human Proto-oncogene Mas
    Cat.:
    E13495r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Proto-oncogene Mas
    Cat.:
    U13495r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Proto-oncogene Mas
    Cat.:
    U13495h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Proto-oncogene Mas
    Cat.:
    U13495m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Proto-oncogene Mas
    Cat.:
    P13495Rb-r
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Proto-oncogene Mas
    Cat.:
    P13495Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Proto-oncogene Mas
    Cat.:
    P13495Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Proto-oncogene Mas
    Monoclonal Antibody for Human Proto-oncogene Mas
    Monoclonal Antibody for Human Proto-oncogene Mas
    Protein for Human Proto-oncogene Mas
    Protein for Human Proto-oncogene Mas
    Protein for Human Proto-oncogene Mas

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Isolation and characterization of a new cellular oncogene encoding a protein with multiple potential transmembrane domains."
      Young D. , Waitches G. , Birchmeier C. , Fasano O. , Wigler M.
      Cell45:711-719(1986) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    2. 2.
      "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Halleck A. , Ebert L. , Mkoundinya M. , Schick M. , Eisenstein S. , Neubert P. , Kstrang K. , Schatten R. , Shen B. , Henze S. , Mar W. , Korn B. , Zuo D. , Hu Y. , LaBaer J.
      Submitted (2004-06) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    3. 3.
      "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J. , Palmer S.A. , Sims S.K. , Edwards C.A. , Ashurst J.L. , Wilming L. , Jones M.C. , Horton R. , Hunt S.E. , Scott C.E. , Gilbert J.G.R. , Clamp M.E. , Bethel G. , Milne S. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Andrews T.D. , more...
      Nature425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 4.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    6. 6.
      "The mas oncogene encodes an angiotensin receptor."
      Jackson T.R. , Blair L.A.C. , Marshall J. , Goedert M. , Hanley M.R.
      Nature335:437-440(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PRELIMINARY FUNCTION
    7. 7.
      "G-protein-coupled receptor Mas is a physiological antagonist of the angiotensin II type 1 receptor."
      Kostenis E. , Milligan G. , Christopoulos A. , Sanchez-Ferrer C.F. , Heringer-Walther S. , Sexton P.M. , Gembardt F. , Kellett E. , Martini L. , Vanderheyden P. , Schultheiss H.P. , Walther T.
      Circulation111:1806-1813(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION AS AGTR1 ANTAGONIST;INTERACTION WITH AGTR1
    8. 8.
      "Up-regulation of the angiotensin II type 1 receptor by the MAS proto-oncogene is due to constitutive activation of Gq/G11 by MAS."
      Canals M. , Jenkins L. , Kellett E. , Milligan G.
      J. Biol. Chem.281:16757-16767(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;MUTAGENESIS OF ILE-138
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