Gene name:
Mavs (Ips1;Visa) ;
Protein name:
Mitochondrial antiviral-signaling protein (MAVS) ;
Alternative:
Interferon beta promoter stimulator protein 1 (IPS-1) ;CARD adapter inducing interferon beta (Cardif) ;Virus-induced-signaling adapter (VISA) ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Interacts with DDX58, IFIH1, TRAF2 and TRAF6. May interact with IRF3, FADD, RIPK1, IKBKE, CHUK and IKBKB. Does not interact with TBK1. Interacts with NLRX1. Interaction with NLRX1 requires the CARD domain (By similarity). Interacts with PSMA7 (By similarity). Interacts with TRAFD1. Interacts (via C-terminus) with PCBP2 in a complex containing MAVS, PCBP2 and ITCH. Interacts with CYLD. Interacts with SRC.
Function:
Required for innate immune defense against viruses. Acts downstream of DDX58 and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFN-beta and RANTES (CCL5). May activate the same pathways following detection of extracellular dsRNA by TLR3. May protect cells from apoptosis.
Subcellular Location:
Mitochondrion outer membrane
Protein Attributes:
50:
MTFAEDKTYK | YIRDNHSKFC | CVDVLEILPY | LSCLTASDQD | RLRASYRQIG |
100:
NRDTLWGLFN | NLQRRPGWVE | VFIRALQICE | LPGLADQVTR | VYQSYLPPGT |
150:
SLRSLEPLQL | PDFPAAVSGP | SAFAPGHNIP | DHGLRETPSC | PKPVQDTQPP |
200:
ESPVENSEQL | LQTNSGAVAR | MSGGSLIPSP | NQQALSPQPS | REHQEQEPEL |
250:
GGAHAANVAS | VPIATYGPVS | PTVSFQPLPR | TALRTNLLSG | VTVSALSADT |
300:
SLSSSSTGSA | FAKGAGDQAK | AATCFSTTLT | NSVTTSSVPS | PRLVPVKTMS |
350:
SKLPLSSKST | AAMTSTVLTN | TAPSKLPSNS | VYAGTVPSRV | PASVAKAPAN |
400:
TIPPERNSKQ | AKETPEGPAT | KVTTGGNQTG | PNSSIRSLHS | GPEMSKPGVL |
450:
VSQLDEPFSA | CSVDLAISPS | SSLVSEPNHG | PEENEYSSFR | IQVDESPSAD |
500:
LLGSPEPLAT | QQPQEEEEHC | ASSMPWAKWL | GATSALLAVF | LAVMLYRSRR |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Rat
Mouse
Human
Polyclonal Antibody for Mouse MAVS
Polyclonal Antibody for Mouse MAVS
Polyclonal Antibody for Mouse MAVS
Monoclonal Antibody for Mouse MAVS
Monoclonal Antibody for Mouse MAVS
Monoclonal Antibody for Mouse MAVS
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
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Cited for : NUCLEOTIDE SEQUENCE [MRNA]
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
4.
"The transcriptional landscape of the mammalian genome."
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain :
C57BL/6J .
tissue :
Liver .
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain :
FVB/N .
tissue :
Eye .
tissue :
Liver .
tissue :
Salivary gland .
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-152 AND SER-384;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Liver .
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH TRAFD1