Mbd1 ELISA Kit for Mouse(Mus musculus) | EIAab.comMbd1 ELISA Kit for Mouse(Mus musculus)

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Mbd1 (Gene name),

Methyl-CpG-binding domain protein 1 (Protein name ), MBD1_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

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Gene name:

Mbd1;

Protein name:

Methyl-CpG-binding domain protein 1;

Alternative:

Methyl-CpG-binding protein MBD1;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Interacts with OASL, AFT7IP, AFT7IP2 and BAHD1. Binds CHAF1A and the SUV39H1-CBX5 complex via the MBD domain. Binds MGP via the TRD domain. May be part of the MeCP1 complex. During DNA replication, it recruits SETDB1 to form a S phase-specific complex that facilitates methylation of H3 'Lys-9' during replication-coupled chromatin assembly and is at least composed of the CAF-1 subunit CHAF1A, MBD1 and SETDB1.

Function:

Transcriptional repressor that binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binding is abolished by the presence of 7-mG that is produced by DNA damage by methylmethanesulfonate (MMS). Acts as transcriptional repressor and plays a role in gene silencing by recruiting AFT7IP, which in turn recruits factors such as the histone methyltransferase SETDB1. Probably forms a complex with SETDB1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation. Isoform 1 can also repress transcription from unmethylated promoters.

Subcellular Location:

Nucleus speckle Chromosome Nuclear, in a punctate pattern. Associated with euchromatic regions of the chromosomes.

Protein Attributes:

Sequence length:

636

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