Protein name:
DNA replication licensing factor MCM5 ;
Alternative:
P1-CDC46 ;CDC46 homolog ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Component of the MCM2-7 complex. The complex forms a toroidal hexameric ring with the proposed subunit order MCM2-MCM6-MCM4-MCM7-MCM3-MCM5 (By simililarity).
Function:
Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (By similarity). Interacts with MCMBP.
Subcellular Location:
Nucleus
Protein Attributes:
50:
MSGFDDPGIF | YSDSFGGDAQ | ADEGQARKSQ | LQRRFKEFLR | QYRVGTDRTG |
100:
FTFKYRDELK | RHYNLGEYWI | EVEMEDLASF | DEDLADYLYK | QPAEHLQLLE |
150:
EAAKEVADEV | TRPRPSGEEV | LQDIQVMLKS | DASPSSIRSL | KSDMMSHLVK |
200:
IPGIIIAASA | VRAKATRISI | QCRSCRNTLT | NIAMRPGLEG | YALPRKCNTD |
250:
QAGRPKCPLD | PYFIMPDKCK | CVDFQTLKLQ | ELPDAVPHGE | MPRHMQLYCD |
300:
RYLCDKVVPG | NRVTIMGIYS | IKKFGLTTSR | GRDRVGVGIR | SSYIRVLGIQ |
350:
VDTDGSGRSF | AGAVSPQEEE | EFRRLAALPN | VYEVISKSIA | PSIFGGTDMK |
400:
KAIACLLFGG | SRKRLPDGLT | RRGDINLLML | GDPGTAKSQL | LKFVEKCSPI |
450:
GVYTSGKGSS | AAGLTASVMR | DPSSRNFIME | GGAMVLADGG | VVCIDEFDKM |
500:
REDDRVAIHE | AMEQQTISIA | KAGITTTLNS | RCSVLAAANS | VFGRWDETKG |
550:
EDNIDFMPTI | LSRFDMIFIV | KDEHNEERDV | MLAKHVITLH | VSALTQTQAV |
600:
EGEIDLAKLK | KFIAYCRVKC | GPRLSAEAAE | KLKNRYIIMR | SGARQHERDS |
650:
DRRSSIPITV | RQLEAIVRIA | EALSKMKLQP | FATEADVEEA | LRLFQVSTLD |
700:
AALSGTLSGV | EGFTSQEDQE | MLSRIEKQLK | RRFAIGSQVS | EHSIIKDFTK |
734:
QKYPEHAIHK | VLQLMLRRGE | IQHRMQRKVL | YRLK
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Bovine
ELISA Kit for Human DNA replication licensing factor MCM5
ELISA Kit for Human DNA replication licensing factor MCM5
ELISA Kit for Human DNA replication licensing factor MCM5
CLIA Kit for Human DNA replication licensing factor MCM5
CLIA Kit for Human DNA replication licensing factor MCM5
CLIA Kit for Human DNA replication licensing factor MCM5
Polyclonal Antibody for Human DNA replication licensing factor MCM5
Polyclonal Antibody for Human DNA replication licensing factor MCM5
Polyclonal Antibody for Human DNA replication licensing factor MCM5
Monoclonal Antibody for Human DNA replication licensing factor MCM5
Monoclonal Antibody for Human DNA replication licensing factor MCM5
Monoclonal Antibody for Human DNA replication licensing factor MCM5
Protein for Human DNA replication licensing factor MCM5
Protein for Human DNA replication licensing factor MCM5
Protein for Human DNA replication licensing factor MCM5
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
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Hu B.
Submitted (1995-07) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
tissue :
Cervix carcinoma .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SEQUENCE REVISION
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
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[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS THR-136; SER-180 AND ILE-258
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Nature402:489-495(1999)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue :
Lymph .
tissue :
Placenta .
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 352-590
tissue :
Cervix .
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION IN THE MCM2-7 COMPLEX;ATPASE ACTIVITY OF THE MCM2-7 COMPLEX
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH MCMBP;IDENTIFICATION IN THE MCM2-7 COMPLEX;IDENTIFICATION BY MASS SPECTROMETRY
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS];CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS]
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-392; LYS-396 AND LYS-696;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
13.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
14.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Proc. Natl. Acad. Sci. U.S.A.109:12449-12454(2012)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]