Protein name:
DNA replication licensing factor MCM8 ;
Alternative:
Minichromosome maintenance 8 ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Interacts with CDC6 and ORC2.
Function:
May have a role in the control of cell proliferation. Appears to be involved in the activation of the prereplicative complex (pre-RC) during G(1) phase by recruiting CDC6 to the origin recognition complex (ORC). Binds chromatin throughout the cell cycle.
Subcellular Location:
Nucleus
Protein Attributes:
50:
MSGAYRGRGF | GRGRFQSWKR | GRGGGNFSGR | WRERENRVDL | NEASGKHASA |
100:
QASQPLLQQS | TLDQFIPYKG | WKLYFSEVYS | NNSPFIEKIQ | AFEKFFTRHI |
150:
DLYDKDEIER | KGSILVDFKE | LTKADEITNL | IPDIENALRD | APEKTLACMG |
200:
LAIHQVLTKD | LERHAAELQA | QEGLSNGGET | MVNVPHIYAR | VYNYEPLTHL |
250:
KNIRATCYGK | YISIRGTVVR | VSNIKPLCTN | MAFQCAACGE | IQSFPLPDGK |
300:
YTLPTKCPVP | ACRGRSFAPL | RSSPLTVTLD | WQLIKIQELM | SDAQREAGRI |
350:
PRTIECELVH | DLVDSCVPGD | TVTVTGIVKV | SNSEEGSRNK | NDKCMFLLYI |
400:
EANSVSNSKG | PKAQTAEDGC | KHGTLMEFSL | KDLYAIREIQ | AEENLLKLVV |
450:
NSLCPVIFGH | ELVKAGLTLA | LFGGSQKYAD | DKNRIPIRGD | PHVLIVGDPG |
500:
LGKSQMLQAA | CNVAPRGVYV | CGNTTTSSGL | TVTLSKDSSS | GDFALEAGAL |
550:
VLGDQGICGI | DEFDKMGNQH | QALLEAMEQQ | SISLAKAGVV | CSLPARTSII |
600:
AAANPVGGHY | NKARTVSENL | KMGSALLSRF | DLVFILLDTP | NEQHDHLLSE |
650:
HVIAIRAGKQ | KAVSSATVTR | VLSQDSNTSV | LEVVSEKPLS | ERLKVAPGEQ |
700:
TDPIPHQLLR | KYIGYARQYV | HPRLSTDAAQ | ALQDFYLELR | KQSQRVGSSP |
750:
ITTRQLESLI | RLTEARARLE | LREEATREDA | EDIIEIMKHS | MLGTYSDEFG |
800:
NLDFERSQHG | SGMSNRSTAK | RFISALNSIA | ERTYNNIFQY | HQLRQIAKEL |
833:
NIQVADFENF | IGSLNDQGYL | LKKGPKIYQL | QTM
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Chicken
Mouse
Bovine
Rat
Human
ELISA Kit for Mouse DNA replication licensing factor MCM8
ELISA Kit for Mouse DNA replication licensing factor MCM8
ELISA Kit for Mouse DNA replication licensing factor MCM8
ELISA Kit for Mouse DNA replication licensing factor MCM8
ELISA Kit for Mouse DNA replication licensing factor MCM8
CLIA Kit for Mouse DNA replication licensing factor MCM8
CLIA Kit for Mouse DNA replication licensing factor MCM8
CLIA Kit for Mouse DNA replication licensing factor MCM8
CLIA Kit for Mouse DNA replication licensing factor MCM8
CLIA Kit for Mouse DNA replication licensing factor MCM8
Polyclonal Antibody for Mouse DNA replication licensing factor MCM8
Polyclonal Antibody for Mouse DNA replication licensing factor MCM8
Polyclonal Antibody for Mouse DNA replication licensing factor MCM8
Polyclonal Antibody for Mouse DNA replication licensing factor MCM8
Polyclonal Antibody for Mouse DNA replication licensing factor MCM8
Monoclonal Antibody for Mouse DNA replication licensing factor MCM8
Monoclonal Antibody for Mouse DNA replication licensing factor MCM8
Monoclonal Antibody for Mouse DNA replication licensing factor MCM8
Monoclonal Antibody for Mouse DNA replication licensing factor MCM8
Monoclonal Antibody for Mouse DNA replication licensing factor MCM8
Protein for Mouse DNA replication licensing factor MCM8
Protein for Mouse DNA replication licensing factor MCM8
Protein for Mouse DNA replication licensing factor MCM8
Protein for Mouse DNA replication licensing factor MCM8
Protein for Mouse DNA replication licensing factor MCM8
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
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more...
Science309:1559-1563(2005)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
strain :
C57BL/6J .
tissue :
Embryonic stem cell .
2.
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more...
PLoS Biol.7:E1000112-E1000112(2009)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain :
C57BL/6J .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
strain :
C57BL/6 .
tissue :
Fetal brain .
5.
"MCM8- and MCM9-deficient mice reveal gametogenesis defects and genome instability due to impaired homologous recombination."
Lutzmann M.
,
Grey C.
,
Traver S.
,
Ganier O.
,
Maya-Mendoza A.
,
Ranisavljevic N.
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Mol. Cell47:523-534(2012)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;IDENTIFICATION IN THE MCM8-MCM9 COMPLEX;DISRUPTION PHENOTYPE