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Index > Protein center > MCMBP(Gene name) > Human
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  • MCMBP (Gene name),
  • Mini-chromosome maintenance complex-binding protein (Protein name ),  MCMBP_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    MCMBP(C10orf119);
    Protein name:
    Mini-chromosome maintenance complex-binding protein(MCM-BP;MCM-binding protein);
    Alternative:

    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with the MCM complex: associates with the MCM3-7 complex which lacks MCM2, while it does not interact with the MCM complex when MCM2 is present (MCM2-7 complex). Interacts with the RPA complex, when composed of all RPA1, RPA2 and RPA3 components, but not with RPA1 or RPA2 alone.
    Function:
    Associated component of the MCM complex that acts as a regulator of DNA replication. Binds to the MCM complex during late S phase and promotes the disassembly of the MCM complex from chromatin, thereby acting as a key regulator of pre-replication complex (pre-RC) unloading from replicated DNA. Can dissociate the MCM complex without addition of ATP; probably acts by destabilizing interactions of each individual subunits of the MCM complex. Required for sister chromatid cohesion.
    Subcellular Location:
    Nucleus Associates with chromatin. Highly associated with chromatin in G1/S and S phases, reduced binding to chromatin in G2, and further decreased binding in early M phase. It then reassociates with chromatin in late M phase. Dissociates from chromatin later than component of the MCM complex.
    Protein Attributes:
    Sequence length:
    642
    Sequence:
    50:
    MPCGEDWLSH | PLGIVQGFFA | QNGVNPDWEK | KVIEYFKEKL | KENNAPKWVP | 
    100:
    SLNEVPLHYL | KPNSFVKFRC | MIQDMFDPEF | YMGVYETVNQ | NTKAHVLHFG | 
    150:
    KYRDVAECGP | QQELDLNSPR | NTTLERQTFY | CVPVPGESTW | VKEAYVNANQ | 
    200:
    ARVSPSTSYT | PSRHKRSYED | DDDMDLQPNK | QKDQHAGARQ | AGSVGGLQWC | 
    250:
    GEPKRLETEA | STGQQLNSLN | LSSPFDLNFP | LPGEKGPACL | VKVYEDWDCF | 
    300:
    KVNDILELYG | ILSVDPVLSI | LNNDERDASA | LLDPMECTDT | AEEQRVHSPP | 
    350:
    ASLVPRIHVI | LAQKLQHINP | LLPACLNKEE | SKTCKFVSSF | MSELSPVRAE | 
    400:
    LLGFLTHALL | GDSLAAEYLI | LHLISTVYTR | RDVLPLGKFT | VNLSGCPRNS | 
    450:
    TFTEHLYRII | QHLVPASFRL | QMTIENMNHL | KFIPHKDYTA | NRLVSGLLQL | 
    500:
    PSNTSLVIDE | TLLEQGQLDT | PGVHNVTALS | NLITWQKVDY | DFSYHQMEFP | 
    550:
    CNINVFITSE | GRSLLPADCQ | IHLQPQLIPP | NMEEYMNSLL | SAVLPSVLNK | 
    600:
    FRIYLTLLRF | LEYSISDEIT | KAVEDDFVEM | RKNDPQSITA | DDLHQLLVVA | 
    642:
    RCLSLSAGQT | TLSRERWLRA | KQLESLRRTR | LQQQKCVNGN | EL
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    KEGG:
    UniGene:
    Pfam:
    String:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human MCM-BP
    ELISA Kit for Human MCM-BP
    ELISA Kit for Human MCM-BP
    ELISA Kit for Human MCM-BP
    ELISA Kit for Human MCM-BP
    CLIA Kit for Human MCM-BP
    CLIA Kit for Human MCM-BP
    CLIA Kit for Human MCM-BP
    CLIA Kit for Human MCM-BP
    CLIA Kit for Human MCM-BP
    Polyclonal Antibody for Human MCM-BP
    Polyclonal Antibody for Human MCM-BP
    Polyclonal Antibody for Human MCM-BP
    Polyclonal Antibody for Human MCM-BP
    Polyclonal Antibody for Human MCM-BP
    Monoclonal Antibody for Human MCM-BP
    Monoclonal Antibody for Human MCM-BP
    Monoclonal Antibody for Human MCM-BP
    Monoclonal Antibody for Human MCM-BP
    Monoclonal Antibody for Human MCM-BP
    Protein for Human MCM-BP
    Protein for Human MCM-BP
    Protein for Human MCM-BP
    Protein for Human MCM-BP
    Protein for Human MCM-BP

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Uterus.
    2. 2.
      "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L. , Schick M. , Neubert P. , Schatten R. , Henze S. , Korn B.
      Submitted (2004-06) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
    3. 3.
      "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P. , Earthrowl M.E. , Grafham D.V. , Rubenfield M. , French L. , Steward C.A. , Sims S.K. , Jones M.C. , Searle S. , Scott C. , Howe K. , Hunt S.E. , Andrews T.D. , Gilbert J.G.R. , Swarbreck D. , Ashurst J.L. , Taylor A. , Battles J. , more...
      Nature429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 340-642 (ISOFORMS 1/2)
      tissue: Muscle.
      tissue: Placenta.
    5. 5.
      "Identification and characterization of a novel component of the human minichromosome maintenance complex."
      Sakwe A.M. , Nguyen T. , Athanasopoulos V. , Shire K. , Frappier L.
      Mol. Cell. Biol.27:3044-3055(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;IDENTIFICATION BY MASS SPECTROMETRY;INTERACTION WITH THE MCM COMPLEX
    6. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-154; THR-160 AND SER-298;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    7. 7.
      "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
      Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    8. 8.
      "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C. , Kumar C. , Gnad F. , Nielsen M.L. , Rehman M. , Walther T.C. , Olsen J.V. , Mann M.
      Science325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    9. 9.
      "Identification of proteins that may directly interact with human RPA."
      Nakaya R. , Takaya J. , Onuki T. , Moritani M. , Nozaki N. , Ishimi Y.
      J. Biochem.148:539-547(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH THE RPA COMPLEX
    10. 10.
      "The MCM-binding protein ETG1 aids sister chromatid cohesion required for postreplicative homologous recombination repair."
      Takahashi N. , Quimbaya M. , Schubert V. , Lammens T. , Vandepoele K. , Schubert I. , Matsui M. , Inze D. , Berx G. , De Veylder L.
      PLoS Genet.6:E1000817-E1000817(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    11. 11.
      "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
      Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-154;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    12. 12.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    13. 13.
      "MCM-BP regulates unloading of the MCM2-7 helicase in late S phase."
      Nishiyama A. , Frappier L. , Mechali M.
      Genes Dev.25:165-175(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    14. 14.
      "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T. , Prokhorova T.A. , Akimov V. , Henningsen J. , Johansen P.T. , Kratchmarova I. , Kassem M. , Mann M. , Olsen J.V. , Blagoev B.
      Sci. Signal.4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-154;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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