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Index > Protein center > Med12l(Gene name) > Mouse
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  • Med12l (Gene name),
  • Mediator of RNA polymerase II transcription subunit 12-like protein (Protein name ),  MD12L_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Gene name:
    Med12l(Kiaa3007);
    Protein name:
    Mediator of RNA polymerase II transcription subunit 12-like protein;
    Alternative:
    Mediator complex subunit 12-like protein;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    May be a component of the Mediator complex, which is known to be composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
    Function:
    May be a component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
    Subcellular Location:
    Nucleus
    Protein Attributes:
    Sequence length:
    2157
    Sequence:
    50:
    MAAFGLLSYE | QRPLKRPRLG | PPDVYPQDPK | QKEDELTAVN | VKQGFNNQPA | 
    100:
    FTGDEHGSAR | NIVINPSKIG | AYFSSILAEK | LKLNTFQDTG | KKKPQVNAKD | 
    150:
    NYWLVTARSQ | SAIHSWFSDL | AGNKPLAILA | KKVPILSKKE | DVFAYLAKYS | 
    200:
    VPMVRATWLI | KMTCAYYSAI | SEAKIKKRQA | PDPNLEWTQI | STRYLREQLV | 
    250:
    KISDFYHMAS | STGDGPVPVP | PEVEQAMKQW | EYNEKLAFHM | FQEGMLEKHE | 
    300:
    YLTWILDVLE | KIRPVDDSLL | KLLLPLMLQY | SDEFVQSAYL | SRRLAYFCAR | 
    350:
    RLSLLLSDSP | NLLAAHSPHM | IIGTNNTSIG | TPSPGTPGPG | MSPVQLAFSD | 
    400:
    FLSCAQHGPL | VYGLSCMLQT | VTLCCPSALV | WNYSTNENKI | SNPGSPLDLL | 
    450:
    QVAPSSLPMP | GGNTAFNQQV | RARIYEVEQQ | IKQRGRAVEV | RWSFDKCQES | 
    500:
    TAGVTISRVL | HTLEVLDRHC | FDRTDSSNSM | ETLYHKIFWA | NQNKDNQEVA | 
    550:
    PNDEAVVTLL | CEWAVSCKRS | GKHRAMAVAK | LLEKRQAEIE | AERCGESEVL | 
    600:
    DEKESISSAS | LAGSSLPVFQ | NVLLRFLDTQ | APALSDPNSE | CEKVEFVNLV | 
    650:
    LLFCEFIRHD | VFSHDAYMCT | LISRGDLSVT | ASTGLRSPAG | ENSDEHYSKD | 
    700:
    HDMKMEIFSP | MPGESCENIN | PSLSRRLSVN | GEKLLKREKP | RELIFPSNYD | 
    750:
    LLRHLQYATH | FPIPLDESSS | HECNQRTILL | YGVGKERDEA | RHQLKKITKD | 
    800:
    ILKILNKKGT | TESGVGDEGQ | KARKTKQEVF | PTPENVFTKL | QLLSYFDQHQ | 
    850:
    VTSQISNNVL | EQITSFASGT | SYHLPLAHHI | QLIFDLMEPA | LNINGLIDFA | 
    900:
    IQLLNELSVV | EAELLLKSSS | LAGSYTTGLC | VCIVAVLRRY | HSCLILNPDQ | 
    950:
    TAQVFEGLCG | VVKHVVNPSE | CSSPERCILA | YLYDLYVSCS | HLRSKFGDLF | 
    1000:
    SSACSKVKQT | IYNNVMPANS | NLRWDPDFMM | DFIENPSARS | INYSMLGKIL | 
    1050:
    NDNAANRYSF | VCNTLMNVCM | GHQDAGRIND | IANFSSELTA | CCTVLSSEWL | 
    1100:
    GVLKALCCSS | NHVWGFNDVL | CTVDVSDLSF | HDSLATFIAI | LIARQCFSLE | 
    1150:
    DVVQHVALPS | LLAAACGDAD | AEPGARMTCR | LLLHLFRAPQ | ACFFPQGTGK | 
    1200:
    PFPGIRSSCD | RHLLAAAHNS | IEVGAVFAVL | KAIMMLGDAK | IGSNNVNTMK | 
    1250:
    NEDFGMRGLR | RDGNAEDAWA | TSQNSKSYGK | SISIETANLR | EYARYVLRTI | 
    1300:
    CQQEWVGEHC | LKEPERLCTD | KELILDPVLS | NMQAQKLLQL | ICYPHGIKEC | 
    1350:
    TEGDNLQRQH | IKRILQNLEQ | WTLRQSWLEL | QLMIKQCLKD | PSSGSVAEMN | 
    1400:
    NLLDNIAKAT | IEVFQQSADL | NNNASNSGMS | LFNPNTIGSV | DPSSTRQNGI | 
    1450:
    KTFLSSSERR | GVWLVAPLIA | RLPTSVQGRV | LKAAGEELEK | GQHLGSSSKK | 
    1500:
    ERDRQKQKSM | SLLSQQPFLS | LVLTCLKGQD | EQREGLLTSL | QNQVNQILSN | 
    1550:
    WREERYQDDT | KARQMMHEAL | QLRLNLVGGM | FDTVQRSTQG | TTDWALLLLQ | 
    1600:
    IITSGTVDMH | TNNELFTTVL | DMLGVLINGT | LASDLSSASP | GGSEENKRAY | 
    1650:
    MNLVKKLKKE | LGDKRSESID | KVRQLLPLPK | QTCDVITCEP | MGSLIDTKGN | 
    1700:
    KIAGFDSIDK | KQARGLQVST | KQKVSPWDLF | EGQKNPAPLS | WAWFGTVRVD | 
    1750:
    RKVIKYEEQQ | HFLLYHTHTM | PKPRSYYLEP | LPLPPEEEEE | ELTSPVSQEP | 
    1800:
    ERKSAELSDQ | GKATADEEKK | TKGRKRKTKS | SSRIDEYQQT | NLYRVPPNYS | 
    1850:
    PMSSQMTHHP | QPALWGYNLV | SQPQQPSFFL | QNPSLNPGGS | RLDPAGSFVP | 
    1900:
    TNTKQALSNM | LQRRSGAMLQ | PPSLHAVTSQ | QQLLQMKLLQ | QQQQQQQQQQ | 
    1950:
    QQQQRLLRQA | QTRPFQQGQP | GDQAALFTAQ | ARPSPQLPQY | PGLQQAQTMP | 
    2000:
    QGYTMYGTQM | PLQQAAQQQP | GGVVLSPSYN | SRAYPAAHSS | PALMERLRQL | 
    2050:
    QQQPSGYVQQ | QASPYLQPVA | GSQRLNHQAL | QQSPLVGGGI | DAVLTPAHPN | 
    2100:
    LPSVPLPQDP | MRPRQQQVRQ | QQRLLQVWGR | EMQQPQQAPQ | PQQPSQTQSQ | 
    2150:
    ALGLQAMQPQ | QPLFPRQGLQ | QTQQQQQTAA | LVRQLQKQLS | SNQPQQGVTP | 
    2157:
    CAHPSHF
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    UniGene:
    UniGene:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Mediator of RNA polymerase II transcription subunit 12-like protein
    ELISA Kit for Mouse Mediator of RNA polymerase II transcription subunit 12-like protein
    CLIA Kit for Mouse Mediator of RNA polymerase II transcription subunit 12-like protein
    CLIA Kit for Mouse Mediator of RNA polymerase II transcription subunit 12-like protein
    Polyclonal Antibody for Mouse Mediator of RNA polymerase II transcription subunit 12-like protein
    Polyclonal Antibody for Mouse Mediator of RNA polymerase II transcription subunit 12-like protein
    Monoclonal Antibody for Mouse Mediator of RNA polymerase II transcription subunit 12-like protein
    Monoclonal Antibody for Mouse Mediator of RNA polymerase II transcription subunit 12-like protein
    Protein for Mouse Mediator of RNA polymerase II transcription subunit 12-like protein
    Protein for Mouse Mediator of RNA polymerase II transcription subunit 12-like protein

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
      Okazaki N. , Kikuno R. , Ohara R. , Inamoto S. , Koseki H. , Hiraoka S. , Saga Y. , Nagase T. , Ohara O. , Koga H.
      DNA Res.10:167-180(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4)
      tissue: Embryonic tail.
    2. 2.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-751 (ISOFORM 2)
      strain: C57BL/6J.
      tissue: Corpus striatum.
      tissue: Thymus.
    3. 3.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
      strain: C57BL/6J.
    4. 4.
      Lubec G. , Sunyer B. , Chen W.-Q.
      Submitted (2009-01) to the UniProtKB
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 162-174;IDENTIFICATION BY MASS SPECTROMETRY
      strain: OF1.
      tissue: Hippocampus.
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