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Index > Protein center > Mdfic(Gene name) > Mouse
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  • Mdfic (Gene name),
  • MyoD family inhibitor domain-containing protein (Protein name ),  MDFIC_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Vaild Sequence
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  • Gene name:
    Mdfic(Kdt1);
    Protein name:
    MyoD family inhibitor domain-containing protein;
    Alternative:
    Kidney cell line-derived transcript 1;I-mfa domain-containing protein;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    The C-terminus interacts with AXIN1, the histidine-rich region of CCNT1/cyclin-T and weakly with LEF1 (By similarity). Interacts with HAND1; leading to sequester HAND1 into the nucleolus and prevent its activity. Interacts with ZIC2.
    Function:
    Acts as a transcriptional activator or repressor. Inhibits the transcriptional activation of Zic family proteins ZIC1, ZIC2 and ZIC3. Retains nuclear Zic proteins ZIC1, ZIC2 and ZIC3 in the cytoplasm. Modulates the expression from cellular promoters. Binds to the axin complex, resulting in an increase in the level of free beta-catenin. Affects axin-regulation of the WNT and JNK signaling pathways.
    Subcellular Location:
    Nucleus Cytoplasm Nucleus nucleolus
    Protein Attributes:
    Sequence length:
    247
    Sequence:
    50:
    MSCAGEALAP | GPAEQQCPVE | AGGGRLGSPA | HEACNEDNTE | KDKRPATSGH | 
    100:
    TRCGLMRDQS | IWPNPSAGEL | VRTQPERLPQ | LQTSAQEPGK | EETGKIKNGG | 
    150:
    HTRMSNGNGI | PHGAKHVSVE | NHKISAPVSQ | KMHRKIQSSL | SVNNDISKKS | 
    200:
    KVNAVFSPKA | ASSPEDCCVH | CILACLFCEF | LTLCNIVLGQ | ASCGICTSEA | 
    247:
    CCCCCGDEMG | DDCSCPCDMD | CGIMDACCES | SDCLEICMEC | CGICFPS
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    Pfam:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse MyoD family inhibitor domain-containing protein
    ELISA Kit for Mouse MyoD family inhibitor domain-containing protein
    CLIA Kit for Mouse MyoD family inhibitor domain-containing protein
    CLIA Kit for Mouse MyoD family inhibitor domain-containing protein
    Polyclonal Antibody for Mouse MyoD family inhibitor domain-containing protein
    Polyclonal Antibody for Mouse MyoD family inhibitor domain-containing protein
    Monoclonal Antibody for Mouse MyoD family inhibitor domain-containing protein
    Monoclonal Antibody for Mouse MyoD family inhibitor domain-containing protein
    Protein for Mouse MyoD family inhibitor domain-containing protein
    Protein for Mouse MyoD family inhibitor domain-containing protein

    R&D Technical Data
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Precision
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Recovery
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    References
    1. 1.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
      strain: C57BL/6J.
      strain: NOD.
      tissue: Aorta.
      tissue: Cerebellum.
      tissue: Eye.
      tissue: Spleen.
      tissue: Vein.
    2. 2.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      strain: C57BL/6.
      tissue: Brain.
    3. 3.
      "Myogenic repressor I-mfa interferes with the function of Zic family proteins."
      Mizugishi K. , Hatayama M. , Tohmonda T. , Ogawa M. , Inoue T. , Mikoshiba K. , Aruga J.
      Biochem. Biophys. Res. Commun.320:233-240(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH ZIC2;SUBCELLULAR LOCATION
    4. 4.
      "Molecular properties of Zic4 and Zic5 proteins: functional diversity within Zic family."
      Ishiguro A. , Inoue T. , Mikoshiba K. , Aruga J.
      Biochem. Biophys. Res. Commun.324:302-307(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH ZIC2;SUBCELLULAR LOCATION
    5. 5.
      "Nucleolar release of Hand1 acts as a molecular switch to determine cell fate."
      Martindill D.M.J. , Risebro C.A. , Smart N. , Franco-Viseras Mdel M. , Rosario C.O. , Swallow C.J. , Dennis J.W. , Riley P.R.
      Nat. Cell Biol.9:1131-1141(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;INTERACTION WITH HAND1
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