Gene name:
Abcb4(Mdr2;Pgp3;Pgy2);
Protein name:
Multidrug resistance protein 2;
Alternative:
P-glycoprotein 2;ATP-binding cassette sub-family B member 4;P-glycoprotein 3;
Organism:
Abcb4_ (Rattus norvegicus).
General Annotation
Sub Unit:
Interacts with HAX1.
Function:
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Subcellular Location:
Membrane
Multi-pass membrane protein
Protein Attributes:
50:
MDLEAARNGT | ARRLDGDFEL | GSISNQSREK | KKKVNLIGPL | TLFRYSDWQD |
100:
KLFMLLGTAM | AIAHGSGLPL | MMIVFGEMTD | KFVDNAGNFS | LPVNFSLSML |
150:
NPGRILEEEM | TRYAYYYSGL | GGGVLLAAYI | QVSFWTLAAG | RQIRKIRQKF |
200:
FHAILRQEMG | WFDIKGTTEL | NTRLTDDISK | ISEGIGDKVG | MFFQAIATFF |
250:
AGFIVGFIRG | WKLTLVIMAI | TAILGLSTAV | WAKILSTFSD | KELAAYAKAG |
300:
AVAEEALGAI | RTVIAFGGQN | KELERYQKHL | ENAKKIGIKK | AISANISMGI |
350:
AFLLIYASYA | LAFWYGSTLV | ISKEYTIGNA | MTVFFSILIG | AFSVGQAAPC |
400:
IDAFPNARGA | AYVIFDIIDN | NPKIDSFSER | GHKPDSIKGN | LEFSDVHFSY |
450:
PSRANIKILK | GLNLKVKSGQ | TVALVGNSGC | GKSTTVQLLQ | RLYDPTEGTI |
500:
SIDGQDIRNF | NVRCLREFIG | VVSQEPVLFS | TTIAENIRYG | RGNVTMDEIK |
550:
KAVKEANAYD | FIMKLPQKFD | TLVGDRGAQL | SGGQKQRIAI | ARALVRNPKI |
600:
LLLDEATSAL | DTESEAEVQA | ALDKAREGRT | TIVIAHRLST | VRNADVIAGF |
650:
EDGVIVEQGS | HSELIKKEGI | YFRLVNMQTS | GSQILSEEFE | VELSDEKAAG |
700:
GVAPNGWKAR | IFRNSTKKSL | KSSRAHQNRL | DVETNELDAN | VPPVSFLKVL |
750:
RLNKTEWPYF | VVGTLCAIAN | GALQPAFSII | LSEMIAIFGP | GDDTVKQQKC |
800:
NMFSLVFLGL | GVHSFFTFFL | QGFTFGKAGE | ILTTRLRSMA | FKAMLRQDMS |
850:
WFDDHKNSTG | ALSTRLATDA | AQVQGATGTR | LALIAQNTAN | LGTGIIISFI |
900:
YGWQLTLLLL | SVVPFIAVAG | IVEMKMLAGN | AKRDKKEMEA | AGKIATEAIE |
950:
NIRTVVSLTQ | ERKFESMYVE | KLHGPYRNSV | RKAHIYGITF | SISQAFMYFS |
1000:
YAGCFRFGSY | LIVNGHMRFK | DVILVFSAIV | LGAVALGHAS | SFAPDYAKAK |
1050:
LSAAYLFSLF | ERQPLIDSYS | REGMWPDKFE | GSVTFNEVVF | NYPTRANVPV |
1100:
LQGLSLEVKK | GQTLALVGSS | GCGKSTVVQL | LERFYDPMAG | TVLLDGQEAK |
1150:
KLNVQWLRAQ | LGIVSQEPIL | FDCSIAKNIA | YGDNSRVVSQ | DEIVRAAKEA |
1200:
NIHPFIETLP | QKYETRVGDK | GTQLSGGQKQ | RIAIARALIR | QPRVLLLDEA |
1250:
TSALDTESEK | VVQEALDKAR | EGRTCIVIAH | RLSTIQNADL | IVVIDNGKVK |
1278:
EHGTHQQLLA | QKGIYFSMVN | IQAGTQNL
Vaild Sequence:
Related Databases
Uniprot:
