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Index > Protein center > Mecp2(Gene name) > Mouse
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  • Mecp2 (Gene name),
  • Methyl-CpG-binding protein 2 (Protein name ),  MECP2_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    Mecp2;
    Protein name:
    Methyl-CpG-binding protein 2(MeCp-2 protein;MeCp2);
    Alternative:

    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Interacts with CDKL5 (By similarity). Interacts with FNBP3.
    Function:
    Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A.
    Subcellular Location:
    Nucleus Colocalized with methyl-CpG in the genome.
    Protein Attributes:
    Sequence length:
    484
    Sequence:
    50:
    MVAGMLGLRE | EKSEDQDLQG | LRDKPLKFKK | AKKDKKEDKE | GKHEPLQPSA | 
    100:
    HHSAEPAEAG | KAETSESSGS | APAVPEASAS | PKQRRSIIRD | RGPMYDDPTL | 
    150:
    PEGWTRKLKQ | RKSGRSAGKY | DVYLINPQGK | AFRSKVELIA | YFEKVGDTSL | 
    200:
    DPNDFDFTVT | GRGSPSRREQ | KPPKKPKSPK | APGTGRGRGR | PKGSGTGRPK | 
    250:
    AAASEGVQVK | RVLEKSPGKL | VVKMPFQASP | GGKGEGGGAT | TSAQVMVIKR | 
    300:
    PGRKRKAEAD | PQAIPKKRGR | KPGSVVAAAA | AEAKKKAVKE | SSIRSVHETV | 
    350:
    LPIKKRKTRE | TVSIEVKEVV | KPLLVSTLGE | KSGKGLKTCK | SPGRKSKESS | 
    400:
    PKGRSSSASS | PPKKEHHHHH | HHSESTKAPM | PLLPSPPPPE | PESSEDPISP | 
    450:
    PEPQDLSSSI | CKEEKMPRGG | SLESDGCPKE | PAKTQPMVAT | TTTVAEKYKH | 
    484:
    RGEGERKDIV | SSSMPRPNRE | EPVDSRTPVT | ERVS
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    Pfam:
    SMR:
    String:
    KEGG:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse MeCp-2 protein
    Cat.:
    E15238r
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Mouse MeCp-2 protein
    Cat.:
    E15238h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Mouse MeCp-2 protein
    Cat.:
    E15238m
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse MeCp-2 protein
    Cat.:
    U15238r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse MeCp-2 protein
    Cat.:
    U15238h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse MeCp-2 protein
    Cat.:
    U15238m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Mouse MeCp-2 protein
    Cat.:
    P15238Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse MeCp-2 protein
    Cat.:
    P15238Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse MeCp-2 protein
    Cat.:
    P15238Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Mouse MeCp-2 protein
    Monoclonal Antibody for Mouse MeCp-2 protein
    Monoclonal Antibody for Mouse MeCp-2 protein
    Protein for Mouse MeCp-2 protein
    Protein for Mouse MeCp-2 protein
    Protein for Mouse MeCp-2 protein

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Identification and characterization of a family of mammalian methyl-CpG binding proteins."
      Hendrich B. , Bird A.
      Mol. Cell. Biol.18:6538-6547(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE (ISOFORM A)
      strain: C57BL/6.
    2. 2.
      "A complex pattern of evolutionary conservation and alternative polyadenylation within the long 3'-untranslated region of the methyl-CpG-binding protein 2 gene (MeCP2) suggests a regulatory role in gene expression."
      Coy J.F. , Sedlacek Z. , Baechner D. , Delius H. , Poustka A.
      Hum. Mol. Genet.8:1253-1262(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE (ISOFORM A)
    3. 3.
      "Comparative analysis of the methyl CpG binding protein 2 locus in man and mouse reveals new untranslated sequences."
      Reichwald K. , Thiessen J. , Wiehe T. , Kioschis P. , Straetling W.H. , Rosenthal A. , Platzer M.
      Submitted (1999-06) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE (ISOFORM A)
    4. 4.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM B)
      strain: C57BL/6J.
      tissue: Visual cortex.
    5. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
      strain: C57BL/6J.
    6. 6.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A)
      strain: FVB/N.
      tissue: Mammary gland.
    7. 7.
      "FBP WW domains and the Abl SH3 domain bind to a specific class of proline-rich ligands."
      Bedford M.T. , Chan D.C. , Leder P.
      EMBO J.16:2376-2383(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH FNBP3
    8. 8.
      "The major form of MeCP2 has a novel N-terminus generated by alternative splicing."
      Kriaucionis S. , Bird A.
      Nucleic Acids Res.32:1818-1823(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION (ISOFORM B);SUBCELLULAR LOCATION
    9. 9.
      "Brain-specific phosphorylation of MeCP2 regulates activity-dependent Bdnf transcription, dendritic growth, and spine maturation."
      Zhou Z. , Hong E.J. , Cohen S. , Zhao W.-N. , Ho H.H. , Schmidt L. , Chen W.G. , Lin Y. , Savner E. , Griffith E.C. , Hu L. , Steen J.A.J. , Weitz C.J. , Greenberg M.E.
      Neuron52:255-269(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-421
    10. 10.
      "Interaction between chromatin proteins MECP2 and ATRX is disrupted by mutations that cause inherited mental retardation."
      Nan X. , Hou J. , Maclean A. , Nasir J. , Lafuente M.J. , Shu X. , Kriaucionis S. , Bird A.
      Proc. Natl. Acad. Sci. U.S.A.104:2709-2714(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ATRX;SUBCELLULAR LOCATION
    11. 11.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DNA-BINDING
    12. 12.
      "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
      Park J. , Chen Y. , Tishkoff D.X. , Peng C. , Tan M. , Dai L. , Xie Z. , Zhang Y. , Zwaans B.M. , Skinner M.E. , Lombard D.B. , Zhao Y.
      Mol. Cell50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-321 AND LYS-447;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Embryonic fibroblast.
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