Med15 ELISA Kit for Mouse(Mus musculus) | EIAab.comMed15 ELISA Kit for Mouse(Mus musculus)

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Med15 (Gene name),

Mediator of RNA polymerase II transcription subunit 15 (Protein name ), MED15_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Med15(Pcqap);

Protein name:

Mediator of RNA polymerase II transcription subunit 15;

Alternative:

Positive cofactor 2 glutamine/Q-rich-associated protein(PC2 glutamine/Q-rich-associated protein;mPcqap);Mediator complex subunit 15;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. Interacts with SMAD2, SMAD3, SREBF1 and SREBF2. Interacts with WWTR1 (By similarity). Interacts with TRIM11.

Function:

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for cholesterol-dependent gene regulation. Positively regulates the Nodal signaling pathway.

Subcellular Location:

Cytoplasm Nucleus

Protein Attributes:

Sequence length:

792

Sequence:

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792:

PFLQSVHRCM | TSRLLQLPDK | HSVTALLNTW | AQSIHQACLS | AA

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

Q924H2

UniGene:

Mm.208970

Pfam:

PF09606

SMR:

Q924H2

Uniprot:

Q924H2

FOR

ELISA Kit for Mouse Mediator of RNA polymerase II transcription subunit 15

CLIA Kit for Mouse Mediator of RNA polymerase II transcription subunit 15

Polyclonal Antibody for Mouse Mediator of RNA polymerase II transcription subunit 15

Monoclonal Antibody for Mouse Mediator of RNA polymerase II transcription subunit 15

Protein for Mouse Mediator of RNA polymerase II transcription subunit 15

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Isolation and characterization of a novel gene from the DiGeorge chromosomal region that encodes for a mediator subunit."
Berti L. , Mittler G. , Przemeck G.K.H. , Stelzer G. , Guenzler B. , Amati F. , Conti E. , Dallapiccola B. , Hrabe' de Angelis M. , Novelli G. , Meisterernst M.
Genomics74:320-332(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
strain: C57BL/6.

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