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Index > Protein center > MED29(Gene name) > Human
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  • MED29 (Gene name),
  • Mediator of RNA polymerase II transcription subunit 29 (Protein name ),  MED29_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    MED29(IXL);
    Protein name:
    Mediator of RNA polymerase II transcription subunit 29;
    Alternative:
    Mediator complex subunit 29;Intersex-like protein;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. Associates with the MED18/MED20 heteromer.
    Function:
    Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
    Subcellular Location:
    Nucleus
    Protein Attributes:
    Sequence length:
    200
    Sequence:
    50:
    MAASQQQASA | ASSAAGVSGP | SSAGGPGPQQ | QPQPPAQLVG | PAQSGLLQQQ | 
    100:
    QQDFDPVQRY | KMLIPQLKES | LQTLMKVAAQ | NLIQNTNIDN | GQKSSDGPIQ | 
    150:
    RFDKCLEEFY | ALCDQLELCL | RLAHECLSQS | CDSAKHSPTL | VPTATKPDAV | 
    200:
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    MIM:
    Pfam:
    String:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human Mediator of RNA polymerase II transcription subunit 29
    ELISA Kit for Human Mediator of RNA polymerase II transcription subunit 29
    ELISA Kit for Human Mediator of RNA polymerase II transcription subunit 29
    CLIA Kit for Human Mediator of RNA polymerase II transcription subunit 29
    CLIA Kit for Human Mediator of RNA polymerase II transcription subunit 29
    CLIA Kit for Human Mediator of RNA polymerase II transcription subunit 29
    Polyclonal Antibody for Human Mediator of RNA polymerase II transcription subunit 29
    Polyclonal Antibody for Human Mediator of RNA polymerase II transcription subunit 29
    Polyclonal Antibody for Human Mediator of RNA polymerase II transcription subunit 29
    Monoclonal Antibody for Human Mediator of RNA polymerase II transcription subunit 29
    Monoclonal Antibody for Human Mediator of RNA polymerase II transcription subunit 29
    Monoclonal Antibody for Human Mediator of RNA polymerase II transcription subunit 29
    Protein for Human Mediator of RNA polymerase II transcription subunit 29
    Protein for Human Mediator of RNA polymerase II transcription subunit 29
    Protein for Human Mediator of RNA polymerase II transcription subunit 29

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    Precision
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    Linearity
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    References
    1. 1.
      "IXL, a new subunit of the mammalian Mediator complex, functions as a transcriptional suppressor."
      Wang Y. , Li Y. , Zeng W. , Zhu C. , Xiao J. , Yuan W. , Wang Y. , Cai Z. , Zhou J. , Liu M. , Wu X.
      Biochem. Biophys. Res. Commun.325:1330-1338(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION;TISSUE SPECIFICITY;SUBCELLULAR LOCATION
      tissue: Embryonic heart.
    2. 2.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
      tissue: Lung.
      tissue: Signet-ring cell carcinoma.
    3. 3.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Testis.
    4. 4.
      "The DNA sequence and biology of human chromosome 19."
      Grimwood J. , Gordon L.A. , Olsen A.S. , Terry A. , Schmutz J. , Lamerdin J.E. , Hellsten U. , Goodstein D. , Couronne O. , Tran-Gyamfi M. , Aerts A. , Altherr M. , Ashworth L. , Bajorek E. , Black S. , Branscomb E. , Caenepeel S. , Carrano A.V. , more...
      Nature428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Brain.
    6. 6.
      "A mammalian homolog of Drosophila melanogaster transcriptional coactivator intersex is a subunit of the mammalian Mediator complex."
      Sato S. , Tomomori-Sato C. , Banks C.A.S. , Parmely T.J. , Sorokina I. , Brower C.S. , Conaway R.C. , Conaway J.W.
      J. Biol. Chem.278:49671-49674(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN THE TRAP/SMCC MEDIATOR COMPLEX;IDENTIFICATION BY MASS SPECTROMETRY;INTERACTION WITH MED18 AND MED20
    7. 7.
      "A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2."
      Tomomori-Sato C. , Sato S. , Parmely T.J. , Banks C.A.S. , Sorokina I. , Florens L. , Zybailov B. , Washburn M.P. , Brower C.S. , Conaway R.C. , Conaway J.W.
      J. Biol. Chem.279:5846-5851(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN THE TRAP/SMCC MEDIATOR COMPLEX
    8. 8.
      "A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology."
      Sato S. , Tomomori-Sato C. , Parmely T.J. , Florens L. , Zybailov B. , Swanson S.K. , Banks C.A.S. , Jin J. , Cai Y. , Washburn M.P. , Conaway J.W. , Conaway R.C.
      Mol. Cell14:685-691(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY;IDENTIFICATION IN THE MEDIATOR COMPLEX
    9. 9.
      "MED1/TRAP220 exists predominantly in a TRAP/Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription."
      Zhang X. , Krutchinsky A. , Fukuda A. , Chen W. , Yamamura S. , Chait B.T. , Roeder R.G.
      Mol. Cell19:89-100(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CCNC; MED1; MED12; MED13; MED17; MED20 AND MED21;IDENTIFICATION BY MASS SPECTROMETRY;IDENTIFICATION IN THE MEDIATOR COMPLEX;ASSOCIATION OF THE MEDIATOR COMPLEX WITH RNA POLYMERASE II
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