Protein name:
Mediator of RNA polymerase II transcription subunit 29 ;
Alternative:
Mediator complex subunit 29 ;Intersex-like protein ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. Associates with the MED18/MED20 heteromer.
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Subcellular Location:
Nucleus
Protein Attributes:
50:
MAASQQQASA | ASSAAGVSGP | SSAGGPGPQQ | QPQPPAQLVG | PAQSGLLQQQ |
100:
QQDFDPVQRY | KMLIPQLKES | LQTLMKVAAQ | NLIQNTNIDN | GQKSSDGPIQ |
150:
RFDKCLEEFY | ALCDQLELCL | RLAHECLSQS | CDSAKHSPTL | VPTATKPDAV |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Bovine
Human
ELISA Kit for Human Mediator of RNA polymerase II transcription subunit 29
ELISA Kit for Human Mediator of RNA polymerase II transcription subunit 29
ELISA Kit for Human Mediator of RNA polymerase II transcription subunit 29
CLIA Kit for Human Mediator of RNA polymerase II transcription subunit 29
CLIA Kit for Human Mediator of RNA polymerase II transcription subunit 29
CLIA Kit for Human Mediator of RNA polymerase II transcription subunit 29
Polyclonal Antibody for Human Mediator of RNA polymerase II transcription subunit 29
Polyclonal Antibody for Human Mediator of RNA polymerase II transcription subunit 29
Polyclonal Antibody for Human Mediator of RNA polymerase II transcription subunit 29
Monoclonal Antibody for Human Mediator of RNA polymerase II transcription subunit 29
Monoclonal Antibody for Human Mediator of RNA polymerase II transcription subunit 29
Monoclonal Antibody for Human Mediator of RNA polymerase II transcription subunit 29
Protein for Human Mediator of RNA polymerase II transcription subunit 29
Protein for Human Mediator of RNA polymerase II transcription subunit 29
Protein for Human Mediator of RNA polymerase II transcription subunit 29
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
"IXL, a new subunit of the mammalian Mediator complex, functions as a transcriptional suppressor."
Wang Y.
,
Li Y.
,
Zeng W.
,
Zhu C.
,
Xiao J.
,
Yuan W.
,
Wang Y.
,
Cai Z.
,
Zhou J.
,
Liu M.
,
Wu X.
Biochem. Biophys. Res. Commun.325:1330-1338(2004)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION;TISSUE SPECIFICITY;SUBCELLULAR LOCATION
tissue :
Embryonic heart .
2.
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T.
,
Suzuki Y.
,
Nishikawa T.
,
Otsuki T.
,
Sugiyama T.
,
Irie R.
,
Wakamatsu A.
,
Hayashi K.
,
Sato H.
,
Nagai K.
,
Kimura K.
,
Makita H.
,
Sekine M.
,
Obayashi M.
,
Nishi T.
,
Shibahara T.
,
Tanaka T.
,
Ishii S.
,
Yamamoto J.
,
Saito K.
,
Kawai Y.
,
Isono Y.
,
Nakamura Y.
,
Nagahari K.
,
Murakami K.
,
Yasuda T.
,
Iwayanagi T.
,
Wagatsuma M.
,
Shiratori A.
,
Sudo H.
,
Hosoiri T.
,
Kaku Y.
,
Kodaira H.
,
Kondo H.
,
Sugawara M.
,
Takahashi M.
,
Kanda K.
,
Yokoi T.
,
Furuya T.
,
Kikkawa E.
,
Omura Y.
,
Abe K.
,
Kamihara K.
,
Katsuta N.
,
Sato K.
,
Tanikawa M.
,
Yamazaki M.
,
Ninomiya K.
,
Ishibashi T.
,
Yamashita H.
,
Murakawa K.
,
Fujimori K.
,
Tanai H.
,
Kimata M.
,
Watanabe M.
,
Hiraoka S.
,
Chiba Y.
,
Ishida S.
,
Ono Y.
,
Takiguchi S.
,
Watanabe S.
,
Yosida M.
,
Hotuta T.
,
Kusano J.
,
Kanehori K.
,
Takahashi-Fujii A.
,
Hara H.
,
Tanase T.-O.
,
Nomura Y.
,
Togiya S.
,
Komai F.
,
Hara R.
,
Takeuchi K.
,
Arita M.
,
Imose N.
,
Musashino K.
,
Yuuki H.
,
Oshima A.
,
Sasaki N.
,
Aotsuka S.
,
Yoshikawa Y.
,
Matsunawa H.
,
Ichihara T.
,
Shiohata N.
,
Sano S.
,
Moriya S.
,
Momiyama H.
,
Satoh N.
,
Takami S.
,
Terashima Y.
,
Suzuki O.
,
Nakagawa S.
,
Senoh A.
,
Mizoguchi H.
,
Goto Y.
,
Shimizu F.
,
Wakebe H.
,
Hishigaki H.
,
Watanabe T.
,
Sugiyama A.
,
Takemoto M.
,
Kawakami B.
,
Yamazaki M.
,
Watanabe K.
,
Kumagai A.
,
Itakura S.
,
Fukuzumi Y.
,
Fujimori Y.
,
Komiyama M.
,
Tashiro H.
,
Tanigami A.
,
Fujiwara T.
,
Ono T.
,
Yamada K.
,
Fujii Y.
,
Ozaki K.
,
Hirao M.
,
Ohmori Y.
,
Kawabata A.
,
Hikiji T.
,
Kobatake N.
,
Inagaki H.
,
Ikema Y.
,
Okamoto S.
,
Okitani R.
,
Kawakami T.
,
Noguchi S.
,
Itoh T.
,
Shigeta K.
,
Senba T.
,
Matsumura K.
,
Nakajima Y.
,
Mizuno T.
,
Morinaga M.
,
Sasaki M.
,
Togashi T.
,
Oyama M.
,
Hata H.
,
Watanabe M.
,
Komatsu T.
,
Mizushima-Sugano J.
,
Satoh T.
,
Shirai Y.
,
Takahashi Y.
,
Nakagawa K.
,
Okumura K.
,
Nagase T.
,
Nomura N.
,
Kikuchi H.
,
Masuho Y.
,
Yamashita R.
,
Nakai K.
,
Yada T.
,
Nakamura Y.
,
Ohara O.
,
Isogai T.
,
Sugano S.
more...
Nat. Genet.36:40-45(2004)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
tissue :
Lung .
tissue :
Signet-ring cell carcinoma .
3.
"The full-ORF clone resource of the German cDNA consortium."
Bechtel S.
,
Rosenfelder H.
,
Duda A.
,
Schmidt C.P.
,
Ernst U.
,
Wellenreuther R.
,
Mehrle A.
,
Schuster C.
,
Bahr A.
,
Bloecker H.
,
Heubner D.
,
Hoerlein A.
,
Michel G.
,
Wedler H.
,
Koehrer K.
,
Ottenwaelder B.
,
Poustka A.
,
Wiemann S.
,
Schupp I.
more...
BMC Genomics8:399-399(2007)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue :
Testis .
4.
"The DNA sequence and biology of human chromosome 19."
Grimwood J.
,
Gordon L.A.
,
Olsen A.S.
,
Terry A.
,
Schmutz J.
,
Lamerdin J.E.
,
Hellsten U.
,
Goodstein D.
,
Couronne O.
,
Tran-Gyamfi M.
,
Aerts A.
,
Altherr M.
,
Ashworth L.
,
Bajorek E.
,
Black S.
,
Branscomb E.
,
Caenepeel S.
,
Carrano A.V.
,
Caoile C.
,
Chan Y.M.
,
Christensen M.
,
Cleland C.A.
,
Copeland A.
,
Dalin E.
,
Dehal P.
,
Denys M.
,
Detter J.C.
,
Escobar J.
,
Flowers D.
,
Fotopulos D.
,
Garcia C.
,
Georgescu A.M.
,
Glavina T.
,
Gomez M.
,
Gonzales E.
,
Groza M.
,
Hammon N.
,
Hawkins T.
,
Haydu L.
,
Ho I.
,
Huang W.
,
Israni S.
,
Jett J.
,
Kadner K.
,
Kimball H.
,
Kobayashi A.
,
Larionov V.
,
Leem S.-H.
,
Lopez F.
,
Lou Y.
,
Lowry S.
,
Malfatti S.
,
Martinez D.
,
McCready P.M.
,
Medina C.
,
Morgan J.
,
Nelson K.
,
Nolan M.
,
Ovcharenko I.
,
Pitluck S.
,
Pollard M.
,
Popkie A.P.
,
Predki P.
,
Quan G.
,
Ramirez L.
,
Rash S.
,
Retterer J.
,
Rodriguez A.
,
Rogers S.
,
Salamov A.
,
Salazar A.
,
She X.
,
Smith D.
,
Slezak T.
,
Solovyev V.
,
Thayer N.
,
Tice H.
,
Tsai M.
,
Ustaszewska A.
,
Vo N.
,
Wagner M.
,
Wheeler J.
,
Wu K.
,
Xie G.
,
Yang J.
,
Dubchak I.
,
Furey T.S.
,
DeJong P.
,
Dickson M.
,
Gordon D.
,
Eichler E.E.
,
Pennacchio L.A.
,
Richardson P.
,
Stubbs L.
,
Rokhsar D.S.
,
Myers R.M.
,
Rubin E.M.
,
Lucas S.M.
more...
Nature428:529-535(2004)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue :
Brain .
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION IN THE TRAP/SMCC MEDIATOR COMPLEX;IDENTIFICATION BY MASS SPECTROMETRY;INTERACTION WITH MED18 AND MED20
7.
"A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2."
Tomomori-Sato C.
,
Sato S.
,
Parmely T.J.
,
Banks C.A.S.
,
Sorokina I.
,
Florens L.
,
Zybailov B.
,
Washburn M.P.
,
Brower C.S.
,
Conaway R.C.
,
Conaway J.W.
J. Biol. Chem.279:5846-5851(2004)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION IN THE TRAP/SMCC MEDIATOR COMPLEX
8.
"A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology."
Sato S.
,
Tomomori-Sato C.
,
Parmely T.J.
,
Florens L.
,
Zybailov B.
,
Swanson S.K.
,
Banks C.A.S.
,
Jin J.
,
Cai Y.
,
Washburn M.P.
,
Conaway J.W.
,
Conaway R.C.
Mol. Cell14:685-691(2004)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY;IDENTIFICATION IN THE MEDIATOR COMPLEX
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH CCNC; MED1; MED12; MED13; MED17; MED20 AND MED21;IDENTIFICATION BY MASS SPECTROMETRY;IDENTIFICATION IN THE MEDIATOR COMPLEX;ASSOCIATION OF THE MEDIATOR COMPLEX WITH RNA POLYMERASE II